Arinjay Sarma’s Post

Synthetic Biology and AAV! Really informative visit to Pall-Cytiva Portsmouth this week with my excellent doctoral student colleagues, Mehtap BAL and Qiantong（Tina） C. to discuss the application of synthetic biology to gene therapy AAV (adeno-associated virus) vector scale up. AAV has emerged as a leading gene therapy delivery platform, with several AAV-based therapies already approved and many more in the pipeline. AAV can package a wide range of genetic payloads, from small transgenes to large gene cassettes, has shown excellent safety and efficacy profiles in clinical trials and can achieve long-term transgene expression in target tissues. But there's still a lot of room for improvement. That's where synthetic biology comes in. With the power of synthetic biology behind it, I'm confident we'll see AAV technologies continue to advance and enable new breakthroughs in treating genetic diseases. #GeneTherapy #SyntheticBiology #AAV #GeneTech

Researchers at the Broad Institute of MIT and Harvard have developed a method to efficiently deliver prime editors, a type of gene editing, into cells in living animals. They engineered virus-like particles (eVLPs) to carry prime editors. In mouse models, the researchers corrected disease-causing mutations in the eyes, partially restoring vision, and demonstrated effective prime editing in the mouse brain without detecting off-target editing. This represents a significant advancement in therapeutic prime editing in animals. #GeneEditing #PrimeEditing #GeneticsResearch #Biotechnology #MIT #HarvardResearch #PrecisionMedicine #GeneticTherapy #VirusLikeParticles #MouseModels #VisionRestoration https://lnkd.in/ey7HKxVN

🔬 Prepare to be inspired! Researchers at the University of Zurich have just achieved a monumental breakthrough in #GeneTherapy. They've developed an innovative method to transport large genes, propelling the field to new heights. Check out the incredible story here: https://okt.to/h7wbCm. #InvestinSwitzerland #LifeSciences #BioTech 🧬 Led by the brilliant Prof. Elvir Becirovic and his team, the REVeRT method is revolutionizing gene therapy. It overcomes the challenges associated with handling larger genes, resulting in increased efficiency and minimal side effects. This game-changing discovery will pave the way for targeted treatments of various conditions, from blood disorders to age-related ailments. Get ready to witness a medical revolution! ❓ Wondering why this is such a big deal? It's all about the flexibility offered by REVeRT. By breaking large genes into smaller fragments at different points, researchers can now precisely tackle a wide range of diseases. This groundbreaking approach is set to impact lives on a global scale! 📍 Switzerland is proving to be a thriving hub for cutting-edge research, particularly in the fields of #LifeSciences and #BioTech. With a supportive ecosystem that fosters innovation, we are witnessing groundbreaking discoveries that have the potential to transform medicine.

🔬 Researchers at the University of Zurich just made a huge leap: they've found a new way to transport large genes. A discovery that has the potential to be a game-changer for #GeneTherapy. 🧬 The REVeRT method, spearheaded by Prof. Elvir Becirovic and his team, is at the core of this breakthrough. Traditional gene therapy techniques have limitations, especially when handling larger genes. REVeRT not only navigates this hurdle, but it also does so with a heightened level of efficiency and minimal side effects. ❓ So, why is this significant? The real innovation lies in the flexibility this method brings to gene therapy. With REVeRT, large genes can be divided into two fragments at various points, offering a precise approach to treating a broad range of conditions – from common blood disorders to diseases associated with aging. 📍 This goes to show that the #GreaterZurichArea is a hub for cutting-edge research, particularly in #LifeSciences and #BioTech. By building an ecosystem that encourages this level of innovation, we're setting the stage for such groundbreaking discoveries that have global implications. 🔍 For a deeper dive into this revolutionary research, check out our full article here: https://okt.to/5vWmrf. And if you're curious about the flourishing life sciences scene in the Greater Zurich Area, head over to our website: https://okt.to/8aSJG3.

"Redefining Genetic Paradigms: #CircularRNAs, once overlooked as splicing anomalies, now shine as pivotal regulators in our genetic machinery. Exhibiting remarkable stability and evolutionary conservation, these non-coding RNAs herald a new era in genomics, offering insights into complex gene regulation mechanisms and potential therapeutic avenues. Their ability to interact with miRNAs, proteins, and even translate into novel peptides underscores the versatility and untapped potential of circRNAs in biomedicine and research. 🌀🔬 #LifeSciences #RNARegulation #BiotechInnovations" https://lnkd.in/g9qfBeXs

The Gene Therapy Insights podcast episode on Energy Replacement in the Light of Aging is live! Our guest is Shahaf Peleg, PhD, a co-founder of Luminova Biotech and a researcher at the Research-Institute for Farm Animal Biology (FBN) 🔬 Join us as we explore the exciting work by the pioneers in the field, who are pushing the boundaries of science by converting light energy into mitochondrial chemical energy - MtON technology. It's not just a paradigm shift; it's a revolutionary way of thinking about human evolution as we face the disorders of aging. 🌿 Ever heard of taking a light-activating proton pump from fungi and integrating it into an animal's mitochondria to upgrade its energy sources? Neither did I, until now! Discover the science behind this innovative approach and its potential to transform the landscape of age-related disorders. 🔍 🧬 Key topics explored: 1️⃣ Discovery of a light-activated proton pump in fungi and exploration of its applications in humans 2️⃣ Energy replacement and its place in mitochondrial dynamics 3️⃣ Connection between epigenetics and metabolism in the pursuit of combating diseases of aging 4️⃣ Comparisons to photobiomodulation as a mitochondrial biogenesis tool 5️⃣ Considerations in the experimental design of a human gene therapy targeting local mitochondria for potential restoration of eyesight and beyond 👉 Your support matters! Like, share, subscribe, and review to help us bring you more thought-provoking episodes in the future. 👥 We value your engagement! Comment below or on your preferred platform with questions, guest suggestions, or topics you'd like us to explore. Listen to the podcast here: https://lnkd.in/ejzJcRUM 🚀 Next on the list - CRISPR base editing for SMA in the landscape of already approved genetic treatments. Subscribe to stay tuned! #BiotechInnovation #GeneTherapy #Optogenetics #MitochondrialScience #Agingscience #HealthcareRevolution #LuminovaBiotech #Longevity #ScienceExploration 🚀🔬

🔬 Researchers at the University of Zurich just made a huge leap: they've found a new way to transport large genes. A discovery that has the potential to be a game-changer for #GeneTherapy. 🧬 The REVeRT method, spearheaded by Prof. Elvir Becirovic and his team, is at the core of this breakthrough. Traditional gene therapy techniques have limitations, especially when handling larger genes. REVeRT not only navigates this hurdle, but it also does so with a heightened level of efficiency and minimal side effects. ❓ So, why is this significant? The real innovation lies in the flexibility this method brings to gene therapy. With REVeRT, large genes can be divided into two fragments at various points, offering a precise approach to treating a broad range of conditions – from common blood disorders to diseases associated with aging. 📍 This goes to show that the #GreaterZurichArea is a hub for cutting-edge research, particularly in #LifeSciences and #BioTech. By building an ecosystem that encourages this level of innovation, we're setting the stage for such groundbreaking discoveries that have global implications. 🔍 For a deeper dive into this revolutionary research, check out our full article here: https://okt.to/xpau6s. And if you're curious about the flourishing life sciences scene in the Greater Zurich Area, head over to our website: https://okt.to/6gxbTI.

🔬 Researchers at the University of Zurich just made a huge leap: they've found a new way to transport large genes. A discovery that has the potential to be a game-changer for #GeneTherapy. 🧬 The REVeRT method, spearheaded by Prof. Elvir Becirovic and his team, is at the core of this breakthrough. Traditional gene therapy techniques have limitations, especially when handling larger genes. REVeRT not only navigates this hurdle, but it also does so with a heightened level of efficiency and minimal side effects. ❓ So, why is this significant? The real innovation lies in the flexibility this method brings to gene therapy. With REVeRT, large genes can be divided into two fragments at various points, offering a precise approach to treating a broad range of conditions – from common blood disorders to diseases associated with aging. 📍 This goes to show that the #GreaterZurichArea is a hub for cutting-edge research, particularly in #LifeSciences and #BioTech. By building an ecosystem that encourages this level of innovation, we're setting the stage for such groundbreaking discoveries that have global implications. 🔍 For a deeper dive into this revolutionary research, check out our full article here: https://okt.to/Hoy0cv. And if you're curious about the flourishing life sciences scene in the Greater Zurich Area, head over to our website: https://okt.to/ZVeG6N.

Genetic modification of individual animal cells through cellular manipulation #GeneManipulation 🤝 Follow us on Discord 🔜: https://lnkd.in/gt823Zd3 _ ❇️ Summary: Researchers at ETH Zurich have developed a method using CRISPR-Cas gene scissors to simultaneously make several dozen gene changes in the cells of a single animal, creating a mosaic-like pattern of genetic modifications. The method was successfully applied in adult mice, allowing researchers to study the ramifications of multiple gene changes in a single experiment. The researchers used the method to gain new insights into a rare genetic disorder in humans known as 22q11.2 deletion syndrome. The technique has the potential to accelerate biomedical research and reduce the need for animal experiments. Hashtags: #chatGPT #CellModification #GeneticEngineering

Exciting Advancement in DNA Editing! A recent study published in Cell by the Kim lab brings us closer to treating mitochondrial DNA (mtDNA) mutations linked to various diseases. They used base editors to achieve A-to-G conversions in human mtDNA, expanding our gene-editing toolbox for potential cures. Mitochondrial diseases affect many, but with gene therapy tools like mitoZFN, mitoTALENs, and mitoARCUS, we can eliminate faulty mtDNA and shift heteroplasmy. The researchers designed a step-wise approach, fusing three components - mitochondrial targeting sequence, TALE protein, and TadA8e adenine deaminase. They achieved remarkable A-to-G editing efficiency in cells, paving the way for targeted DNA changes. Moreover, the team developed monomeric and dimeric adenosine base editors, each offering unique editing patterns for precise mtDNA modifications. To ensure safety, the study showed low off-target editing frequencies. Delivery was addressed by using smaller mTALEDs, enhancing the potential for in vivo gene correction. This breakthrough brings hope for treating mitochondrial diseases and opens doors to relevant disease models. The future of gene editing looks promising!  #ScienceNews #GeneEditing #MitochondrialDiseases #Reseaprojournals #reseapro #geneediting #mtDNA #mitochondrialdiseases #baseeditors #TadA8e #mTALEDs #genetherapy #genecures #scientificresearch #breakthrough #hope #dna #mutation #disease #science #research #technology #biology #genetics #genomics #evolution #medicine #geneeditingrevolution #mitochondrialdiseasecure #baseeditorsformitochondrialdiseases #mtDNAediting #mTALEDsforgenetherapy #geneeditingforhope #thefutureofgeneediting