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Principles of Molecular Probe Design and Applications

  • Book
  • © 2023

Overview

Authors:
  1. Wellington Pham

    1. Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, USA

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  • Covers the design and applications of probes that are used in all three key imaging modalities

  • Describes various schemes for the synthesis of imaging agents applicable to preclinical animal models and clinical work

  • Classifies probe design to the simplest pedagogical methods to promote self- and cross-disciplined training

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Table of contents (6 chapters)

  1. Front Matter

    Pages iii-x
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  2. Overview of the Fundamentals of Chemistry for Molecular Probe Design

    • Wellington Pham
    Pages 1-36

  3. Principles for the Design of Fluorescent Dyes

    • Wellington Pham
    Pages 37-77

  4. Principles for the Design of PET Probes

    • Wellington Pham
    Pages 79-145

  5. Principles for the Design of MRI Probes

    • Wellington Pham
    Pages 147-199

  6. Solid-Phase Chemistry

    • Wellington Pham
    Pages 201-237

  7. Construction of Molecular Probes and Imaging Applications

    • Wellington Pham
    Pages 239-309

  8. Back Matter

    Pages 311-317
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Keywords

About this book

This book describes insight mechanisms for designing molecular probes and methods that these agents can be used for medical diagnosis in preclinical animal models via optical, MRI and PET imaging. The book has a wealth of schemes of synthesis and methods deduced from pioneers in the field, making it possible to immerse into real-world molecular imaging. Written for graduate student training and practitioners, this book will serve as a teaching material and/or reference for anyone interested in exploring the power of chemical synthesis of imaging agents.

Authors and Affiliations

  • Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, USA

    Wellington Pham

About the author

Wellington Pham received a Ph.D. degree in Medicinal Chemistry from the University of Toledo. His postdoctoral training focused on PET chemistry at The Crump Institute for Molecular Imaging, UCLA Medical School, followed by two postdoctoral trainings in molecular imaging at the Center of Molecular Imaging Research and the Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School. Currently, he is Professor of Radiology at Vanderbilt University Medical Center and holds joint appointments in the Departments of Biomedical Engineering, Vanderbilt Ingram Cancer Center, and Vanderbilt Brain Institute. He served on several steering committees and conference organizers on molecular imaging and molecular probes and a recipient of the Distinguished Investigator Award of the Academy for Radiology & Biomedical Imaging Research (2019). His research interests include the discovery of biomarkers and imaging probes, combined with delivery technologies dedicated to cancer and Alzheimer’s disease, and he has published nearly 150 publications, including peer-reviewed articles, book chapters, conference abstracts/proceedings, editorials, and patents on these subjects. His research has been funded by NIH, DOD, VA grants, and ADEKA Corporation.   

Bibliographic Information

  • Book Title: Principles of Molecular Probe Design and Applications

  • Authors: Wellington Pham

  • DOI: https://doi.org/10.1007/978-981-19-5739-0

  • Publisher: Springer Singapore

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-19-5738-3Published: 27 September 2022

  • Softcover ISBN: 978-981-19-5741-3Published: 28 September 2023

  • eBook ISBN: 978-981-19-5739-0Published: 26 September 2022

  • Edition Number: 1

  • Number of Pages: IX, 317

  • Number of Illustrations: 216 b/w illustrations, 50 illustrations in colour

  • Topics: Biomedical Engineering and Bioengineering, Atomic/Molecular Structure and Spectra, Biological and Medical Physics, Biophysics

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