GOT2 consider the tumor microenvironment

Brian T Do; Matthew G Vander Heiden

doi:10.1016/j.trecan.2022.09.004

GOT2 consider the tumor microenvironment

Trends Cancer. 2022 Nov;8(11):884-886. doi: 10.1016/j.trecan.2022.09.004. Epub 2022 Sep 21.

Authors

Brian T Do¹, Matthew G Vander Heiden²

Affiliations

¹ Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.
² Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.

Abstract

To thrive in a hypoxic and nutrient-limited tumor microenvironment, pancreatic ductal adenocarcinoma (PDAC) cells rewire their metabolism. Understanding PDAC cell metabolism may uncover vulnerabilities that can be targeted for improved therapy. Three recent studies find that the PDAC tumor microenvironment modulates the functional consequences of depleting the mitochondrially localized aspartate transaminase GOT2, thus providing new insights into the metabolism of this lethal cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aspartate Aminotransferases / metabolism
Carcinoma, Pancreatic Ductal* / pathology
Humans
Pancreatic Neoplasms* / therapy
Tumor Microenvironment

Substances

Aspartate Aminotransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding