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SAN FRANCISCO — It was supposed to be a showcase for the way in which technology can revolutionize how some patients take their medications — and ultimately improve health outcomes. It has proven far more complicated.

Proteus Digital Health, a Silicon Valley company, raised close to $500 million and soared to a valuation of $1.5 billion on the promise that its sensor technology could be used to monitor whether patients with a wide range of health conditions have taken their pills. Then, late last year, the company’s funds fell dangerously low.

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Now, Proteus’ CEO, Andrew Thompson, told STAT that the company and Japanese drug maker Otsuka Pharmaceutical have prematurely ended a deal in which Otsuka had been paying Proteus to help it develop a portfolio of digital medicines for serious mental health conditions. That revenue source for Proteus is now gone — and it marks an inauspicious end to a collaboration that produced the first so-called digital pill to win approval from the Food and Drug Administration.

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