Fork restart: unloading FANCD2 to travel ahead

Divya R Iyer; Alan D D'Andrea

doi:10.1016/j.molcel.2023.09.027

Fork restart: unloading FANCD2 to travel ahead

Mol Cell. 2023 Oct 19;83(20):3590-3592. doi: 10.1016/j.molcel.2023.09.027.

Authors

Divya R Iyer¹, Alan D D'Andrea²

Affiliations

¹ Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
² Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: alan_dandrea@dfci.harvard.edu.

PMID: 37863027
DOI: 10.1016/j.molcel.2023.09.027

Abstract

In this issue of Molecular Cell, Brunner et al.¹ reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

DNA Replication*
DNA-Binding Proteins* / metabolism

Substances

DNA-Binding Proteins

Grants and funding

R01 HL052725/HL/NHLBI NIH HHS/United States