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Small Business Funding Opportunities Are Open

Prepare your applications for the next deadline: Apr. 5, 2023, at 5:00 p.m. local time
The National Center for Advancing Translational Sciences (NCATS) invites small businesses and research organizations involved in commercializing innovative medical technologies to apply for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding through the following investigator-initiated and targeted grants and contracts.

NCATS is particularly interested in applications that address research areas relevant to any stage of translation, from target validation through pre-clinical and clinical evaluation, to intervention implementation and dissemination, including: PHS 2022-2 Omnibus Solicitation of the NIH
The 2022-2 Omnibus Solicitation is open to small business researchers and entrepreneurs working on innovative technologies in translational sciences. Standard deadlines apply. The next due date is Apr. 5, 2023, at 5:00 pm EDT. Please note: NCATS will not accept SBIR/STTR applications that include clinical trials under the current Omnibus Solicitation. Learn more.
Additional Funding Opportunities 
NCATS has several other contracts and targeted grant opportunities available through the SBIR and STTR programs for entrepreneurs aiming to commercialize innovations in translational science. Visit NCATS’ Open Small Business Opportunities for more information about the following funding announcements.
  1. Botulinum Toxin Potency Assay Using Tissue Chips (BoT PATCh)
    SBIR RFA-TR-22-032 and STTR RFA-TR-22-031
    Next deadlines: Feb. 22 and August 21, 2023.
  2. Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)
    SBIR RFA-TR-22-029
    Next Deadline: March 15, 2023
  3. NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)
    SBIR RFA-HL-23-008
    Next deadline: Feb. 28, 2023
SBIR and STTR applicants can apply for Phase I and Phase II funding. SBIR applicants can also now opt to apply for Direct-to-Phase II Funding. This award allows small businesses to submit Direct-to-Phase II SBIR applications if the small business has performed the Phase I stage-type research through other funding sources. The SF424 SBIR/STTR Application Guide with additional instructions for the SBIR Direct-to-Phase II application preparation and submission is also available.
Questions? NCATS encourages applicants to email NCATS-SBIRSTTR@mail.nih.gov to discuss potential project ideas and related questions.
Why Apply?
  • Funding is stable, predictable and not a loan
  • Capital is non-dilutive
  • Small businesses and research organizations retain intellectual property rights
  • NIH’s rigorous peer-review provides recognition, validation and visibility to early-stage companies
  • Prestige associated with these awards can help attract more funding or other support (e.g., venture capital, strategic partners)
Tips for Applying
  1. Clear all administrative requirements: Applicants must meet all eligibility requirements and must complete all required registrations prior to submission. Register your small business with SAM.gov, Grants.gov, SBA Company Registry and the NIH eRA Commons as soon as possible. If you are registering after April 4, 2022, you will need to obtain a Unique Entity Identifier (UEI) through Sam.gov. Entities already registered in eRA Commons before April 4 will have a UEI number assigned to them. See additional information on transitioning from DUNS to the UEI.
  2. Principal Investigators must also individually register with NIH eRA Commons. Those eligible to certify as a Women-Owned Small Business (WOSB) should obtain the WOSB designation, and those eligible to certify as a Minority-Owned Small Business should obtain certification.
  3. Build and submit a strong application: Follow the SBIR/STTR Application Guide to ensure proper grant application content and format. You can also find examples of successful applications on a variety of topics on the NIH website.
  4. Submit before the deadline: Completing all the required steps can take a month or two, so don’t wait until the last minute: Plan ahead to help ensure your application moves forward for consideration successfully.
Connect with us! Like us on Facebook, visit us on LinkedIn and follow us on Twitter. Use #NCATSsbir and join the online conversation.
NCATS’ SBIR and STTR programs are engines of innovation for developing and commercializing tools, technologies and intervention platforms to support the creation of new therapeutics and diagnostics. SBIR and STTR are government set-aside programs for domestic small businesses to engage in research and development that has the potential for commercialization and public benefit.
 

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