A HUGE Congratulations to Guillaume Hoareau for TWO $1 Million+ Grants Funded!!
Title: Development of GJA1-20k as a novel treatment for hemorrhagic shock: minimizing mitochondrial injury to mitigate ischemia-reperfusion injury Sponsor: Department of Defense Mechanism: PRMRP Technology/Therapeutic Development Award (TTDA) Funding Period: 04/15/2024 - 04/14/2028 Total Award:~$2,984,854
Title: Advanced Resuscitation Products for Canine Hemorrhagic Shock Sponsor: Defense Health Agency / USAISR (Sub) Funding Period: Pending Total Award:~$1,301,830
Dr. Hoareau is also currently serving on the following DOD review panel:
2025 Combat Casualty Care Research Program (CCCRP) PFC \/
The University of Utah supports research, engages communities, and cares for patients across the largest geographical area in the U.S. The intermountain region is vast, sparsely populated with varying geographical conditions, severe access issues, and supported by limited infrastructure and resources.
From a research standpoint, these challenges make the intermountain region an ideal location for studying remote and austere conditions. To that end, the University of Utah Vice President for Research Office is excited to announce the Remote and Austere Conditions (RAC) Grand Challenge initiative. This initiative seeks to fund innovative research projects that focus on developing novel techniques, technologies, and methods for remote and austere environments.
The U.S. Army defines remote and austere conditions as “environments where access to clean water, electricity, and to a fixed or mobile medical facility is significantly degraded or denied, and where diagnostic and treatment resources and medical personnel are unavailable or limited for extended periods of time.” These conditions are common in frontier counties, areas with less than 20 people per square mile and a travel time of at least 30 minutes to basic services. Approximately 56% of the U.S. is frontier and the majority of that is concentrated in the intermountain region.
The Remote & Austere Conditions (RAC) Grand Challenge funds innovative responses to the threats and obstacles of these extreme environments. From advances in communication and robotics, breakthroughs in patient triage and patient resuscitation, to effective behavioral and community interventions, the RAC Grand Challenge seeks bold approaches to enhance the safety and well-being of populations living in challenging areas with limited or no resources.
Proposals can focus on any challenge within remote and austere conditions. Example topics include power generation; resuscitation techniques; environmental hazards; telemedicine and digital health; remote education and learning; portable diagnostic tools; preparation for the austere; AI and ML; low-energy high-output remote sensors; and training, simulation, and upfitting. As noted, these are simply examples of possible research topics to be explored for the RAC Grand Challenge. From a topic standpoint, research teams are encouraged to push the boundaries and seek to continually expand what it means to conduct research focused on remote and austere conditions.
CTSI STARS T32 Training Program Call for Applications
The STARS T32 Training Program welcomes applications for pre-doctoral and post-doctoral appointments with an anticipated start date of July 1st, 2024.
The STARS Program provides pre-doctoral and post-doctoral training opportunities in translational research across 3 spheres of emphasis (Discovery, Demonstration, and Dissemination) that together define our STARS, or Spheres of Translation Across the Research Spectrum.
Application Due Date: March 4th, 2024, at 11:59 p.m. MST
SIREN OHSU Hub Scholar Program in Emergency Care Research
The SIREN OHSU Hub Scholar Program capitalizes on the unique partnerships across multiple sites and opportunities to learn emergency care research within the SIREN network. The 2-year program is designed to interface with existing research training programs (e.g., fellowships, career development awards). The programmatic goal is to produce highly trained physician-scientists in emergency care research with a focus on clinical trials. The primary scholar goal is submission of an individual K or R federal grant application as PI (with funding secured shortly after completion of the program). The career development goals are: 1) a research training experience, including didactic education and other educational activities; 2) a multi-disciplinary mentored research experience focusing on a scholar-driven project and academic faculty development; and 3) incorporation of scholars into SIREN network activities, trials, and workgroups.
We will select two physician-scientist scholars per year (total 10 scholars over the 5-year SIREN grant), with a target of ≥ 1 scholar per site across all OHSU Hub network sites. Eligible scholars include fellows and faculty at the Clinical Instructor or Assistant Professor level from any discipline involved in emergency care research.
Training duration will be two years per scholar, with a total research budget of $25,000 per scholar to be spent over 2 years. Because the award is not large enough to cover sufficient scholar FTE, the primary department is expected to provide at least 50% protected time for research and training (e.g., through departmental funding or other training awards) and resources to maximize scholar success. Each scholar will remain at their home institution, with primary mentorship provided at their site. Additional mentors can be internal or external. To have a scholar, the site must actively participate in a SIREN trial and integrate the scholar into the trial at their site. Engagement with local CTSA resources and training opportunities is strongly encouraged. The Hub will provide administrative services, facilitate integration of scholars into SIREN workgroups and activities, coordinate inter-site training opportunities and collaboration, and programmatic oversight.
Save-the-Date: SBIR/STTR Program Seminar (NIH/National Cancer Institute)
Date:April 17, 2024 Time: TBD Location: Altitude Lab (Room TBD) Meeting Type: In-person only Participants: Those interested in starting a company or planning on collaborating with a small business entity. Contact:wonyong.lee@utah.edu Description: Join us to learn about the America’s Seed Fund Opportunity for Small Business Startup Companies through the NIH National Cancer Institute SBIR/STTR Programs (SBIR/STTR is known as America’s Seed Fund). This will benefit anyone interested in starting a company or planning on collaborating with small business entities. Two NCI program directors (William Bozza and Jonathan Franca-Koh) will present the institute’s SBIR programs and participants will have the opportunity to have one-on-one discussion with interested parties. Note: Amgen/Genzyme/Biogen/Illumina/23andMe were funded through the SBIR programs at startup-stage. If you would like a pre-seminar introduction to the SBIR/STTR programs, please contact wonyong.lee@utah.edu to schedule for presentation/discussion. Please see the attached flyer for the event.
Free for U: Publishing Open Access Just Got Easier and Affordable
Researchers at the University of Utah can now publish open access at no cost to them. The J. Willard Marriott Library has partnered with the Office of the Vice President for Research to facilitate open-access publishing through licensing agreements with scholarly publishers Wiley and Oxford University Press (OUP).
Both agreements allow corresponding authors to publish their research open access free of charge across Wiley’s more than 2,000 journals and OUP’s more than 500 journals. The three-year agreements run from January 2024 to December 2026. Additional benefits to authors include high-quality peer review, streamlined process, copyright retention and high visibility.
Training on Wiley Publishing To learn more about Wiley’s journals and how their agreement works, please attend an information session hosted by Marriott Library via zoom on Wednesday, February 28 at 2:00 P.M. Participants must register.
Authorship Support Group To learn more about how the new agreements work, please attend the Authorship Support Group at the library via zoom on Wednesday, February 21 at 2 P.M. Questions? Contact Allyson Mower.
Principles of Effective Writing Workshop: Conciseness & Cutting Clutter (February)
Date: Friday, February 16, 2024 Time: 11:00 am – 12:00 pm (MST) Location: Zoom (link will be sent to those who register) Meeting Type: Virtual only Participants: Open to all faculty. RSVP Link:https://forms.gle/AUi75AmPU3XAd7xr5 Contact:vasiliki.karahalios@utah.edu Description: Join us for the first of a series of writing workshops focused on writing and editing for grants, fellowships, and other external funding opportunities. This workshop, Principles of Effective Writing: Conciseness & Cutting Clutter, will focus on brevity, cutting clutter, and editing techniques. Please reserve your spot for Friday, February 16, 2024, at 11:00 AM over Zoom. All faculty and researchers are welcome!
Principles of Effective Writing Workshop: Active Voice & Writing with Verbs (April)
Date: Friday, April 5, 2024 Time: 11:00 am – 12:00 pm (MST) Location: Zoom (link will be sent to those who register) Meeting Type: Virtual only Participants: Open to all faculty. RSVP Link:https://forms.gle/WcQEqg67r4C8fc7A8 Contact:vasiliki.karahalios@utah.edu Description: Join us for the second writing workshop on writing and editing for grants, fellowships, and other external funding opportunities. This workshop, Principles of Effective Writing: Active Voice & Writing with Verbs, will focus on writing with strong, active verbs. We will also review writing in the active voice, avoiding turning verbs into nouns, choosing strong verbs, and quickly getting to the main verb of a sentence. Please reserve your spot for Friday, April 5, 2024, at 11:00 AM over Zoom. All faculty and researchers are welcome!
We need research projects for our Undergraduate Research Associates Program!
Our program offers motivated undergraduate students the chance to participate in emergency medicine research projects. We anticipate having 20-30 volunteer students available for research assignments in the Spring 2024 semester who have committed to a minimum of one 4-hour shift per week and one year of effort, with availability on all seven days of the week. We kindly request your guidance in identifying suitable projects for undergraduate involvement. If you have ongoing research, quality improvement, or other related initiatives that could benefit from our students' contributions, we would appreciate the chance to discuss them further. Your suggestions and recommendations regarding the integration of our students into your research environment are also welcomed. Please reach out to Marina Griffith, Devin Thomas, or Kate Flynn with your projects or questions.
**REMINDER**
Please send ALL research contracts and budgets to Austin Stevens (austin.stevens@hsc.utah.edu) for review and processing to ensure compliance with University policy and adequate budgeting.
FY2023 RESEARCH DASHBOARD
ABSTRACT DEADLINES
Upcoming Abstract Deadlines
MEETING
MEETING DATE
LOCATION
ABSTRACT DEADLINE
ABSTRACT INFO
American Academy of Emergency Medicine (AAEM)
Mediterranean Emergency Medicine Congress
Clinical Trials Network: New England Node: CTN0099 ED-INNOVATION Supplement
Yale University
$1,977,188
6/1/2020
2/28/2024
Fuller
Preventing Emerging Infections through Vaccine Effectiveness Testing II - COVID (PROJECT PREVENT II)
University of California Los Angeles
$244,065
10/1/2022
4/30/2024
Hoareau
Extending Duration of Aortic Occlusion: Can Mitochondrial-Targeted Peptides Prevent Ischemic Reperfusion Injury in a Swine Model of Combat Injury
ABSS SOLUTIONS INC
$149,924
1/29/2024
9/25/2024
Hoareau
GJA1-20K Peptide Therapy to Mitigate Ischemia-Reperfusion Injury after Sever Hemorrhage
Nora Eccles Treadwell Foundation
$100,000
7/1/2023
6/30/2024
Hoareau
Utah Caregiver Assistance for Researchers in Early Stages (U-CARES)
University of Utah
$50,000
10/1/2022
10/14/2024
Hoareau
Development of GJA1-20k as a novel treatment for hemorrhagic shock: minimizing mitochondrial injury to mitigate ischemia-reperfusion injury
US DEPARTMENT OF DEFENSE
$3,067,897
4/15/2024
4/14/2027
Johnson
VentRight Technologies: Portable Ventilation Monitoring Optimizing Critical Care across the Ventilation Continuum
Military & Health Research Foundation
$151,603
11/6/2019
8/30/2024
Johnson
Partially Automated Critical Care MANagement (PACC-MAN)
Military & Health Research Foundation
$20,217
9/19/2022
9/18/2024
Johnson
EPISODE-VS: hEad Pulse for Ischemic StrOke Validation Study
MindRhythm
$53,276
10/1/2022
9/30/2024
Johnson
Endovascular blood pressure targeting in cardiac arrest, a translational research study
NIH/NHLBI
$1,701,829
9/1/2022
8/31/2025
Johnson
Portable Device for Rapid Vascular Access in Trauma and Hemorrhage Control
Philips Healthcare
$332,394
9/30/2020
12/29/2024
Johnson
Intensifying Community Referrals for Health: The SINCERE Intervention to Address COVID-19 Health Disparities
UU College of Nursing
$108,336
5/14/2021
3/31/2025
Kelly
Enhancing U.S. Surveillance of Laboratory Confirmed SARS-CoV-2, Influenza, and other Respiratory Viruses through a Network of Emergency Departments
Wayne State University
$599,105
9/15/2021
9/14/2024
Ledyard
Brain Oxygen Optimization in Severe TBI Phase -3 (BOOST-3)
University of Michigan
$459,500
7/1/2018
11/30/2024
Ockerse
Sonosite PX PIV Image and Data Collection Study
FUJIFILM Sonosite
$22,550
10/25/2022
2/29/2024
Ockerse
Sonosite PX TEU Lung Optimization and Engineering Clinical Evaluation Plan
FUJIFILM Sonosite
$23,740
11/8/2023
11/8/2025
Palatinus
Intramuscular Epinephrine Pharmacokinetics and Dose Optimization in a Swine Model of Out-of-Hospital Cardiac Arrest
Emergency Medicine Foundation
$50,000
7/1/2023
6/30/2024
Taillac
University of Utah Emergency Department-Initiated Buprenorphine for Opioid Use Disorder
Utah Department of Health
$2,580,132
1/15/2019
6/30/2025
Youngquist
University of Utah/CoLabs Medical Inc. Reboa Follow-Up Data
CoLabs Medical
$27,070
7/1/2022
6/30/2025
Youngquist
REMI Platform for Remote EEG Monitoring
Epitel
$169,112
1/1/2023
12/31/2024
Youngquist
Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP)
University of Michigan
$41,177
9/19/2019
8/31/2024
Youngquist
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation
University of Michigan
$1,350
8/1/2023
7/31/2024
Youngquist
Biomarkers in the Brain Oxygen Optimization in Severe TBI Trial (Bio-BOOST)
University of Michigan
$15,000
9/30/2020
9/29/2024
PUBLICATIONS (October - December 2023)
Phadnis
S, Mirza Z, Solano J, Shih R, Hughes P, Clayton L, Alter S. 348 Effect of Prior Antithrombotic
Medication Use on Patients Receiving Emergent Comprehensive Stroke Treatment.
Annals of Emergency Medicine. 2023;82(4):S152-S153. doi:
10.1016/j.annemergmed.2023.08.373.
Eisenberg
J, Tedford NJ, Weaver N, Becker S, Moss MJ. Adverse Outcomes in Topical Lidocaine Exposure: A
Pediatric Case Series From the United States National Poison Data System.
Clin Pediatr (Phila). 2023 Nov;62(11):1390-1397. Epub 20230312. doi:
10.1177/00099228231159646.
Gottlieb
M, Fix M. Bougie
First: Rethinking the Modern Airway Algorithm. Ann Emerg Med. 2024
Feb;83(2):145-146. Epub 20231011. doi: 10.1016/j.annemergmed.2023.09.002.
Fink PB, Brant-Zawadzki G.
"Can" Is Not "Should": A Response to The Use of
Intravenous Lidocaine as an Analgesic Modality in the Austere Environment by
Dryden et al. Wilderness Environ Med. 2023 Sep;34(3):393-394. Epub
20230221. doi: 10.1016/j.wem.2023.01.004.
Hirahara
AM, Khan MS, Ishidoya Y, Smego D, Roman O, Ranjan R, Krueger L, Hoareau G, Selzman CH,
Dosdall DJ. Canine Model of Ischemia-Induced Ventricular Tachycardia. J Surg
Res. 2024 Jan;293:196-203. Epub 20230929. doi: 10.1016/j.jss.2023.09.003.
Dorji
T, Giri S, Tshering U, LeVine S, Tshering U, Chhetri S, Dhakal N, Gaikwad SN,
Flaherty GT, Lucero-Prisno DE, 3rd, McIntosh S. Challenges in the management of high-altitude illnesses
and emergencies in Bhutan and Nepal. Travel Med Infect Dis. 2023
Nov-Dec;56:102660. Epub 20231104. doi: 10.1016/j.tmaid.2023.102660.
Turchiaro
ML, Solano JJ, Clayton LM, Hughes PG, Shih RD, Alter SM. Computed Tomography Imaging of
Geriatric Patients with Uncertain Head Trauma. Journal of Emergency Medicine.
2023;65(6):e511-e516. doi: 10.1016/j.jemermed.2023.07.009.
Patel
N, Johnson MA,
Vapniarsky N, Van Brocklin MW, Williams TK, Youngquist
ST, Ford R, Ewer N, Neff LP, Hoareau GL. Elamipretide
mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.
Scientific Reports. 2023;13(1). doi: 10.1038/s41598-023-31374-5.
Krulewitz
N, Levin NM, Youngquist S, Kelly C, Hoareau G, Johnson MA, Ockerse P. Evaluation of esophageal injuries after defibrillation
with transesophageal ultrasound probe in the mid-esophagus in pigs. Am J
Emerg Med. 2023 Dec;74:14-16. Epub 20230912. doi: 10.1016/j.ajem.2023.09.010.
Lewis
BR, Garland EL, Byrne K, Durns T, Hendrick J, Beck A, Thielking P. HOPE: A Pilot Study of Psilocybin
Enhanced Group Psychotherapy in Patients With Cancer. J Pain Symptom Manage.
2023 Sep;66(3):258-269. Epub 20230610. doi:
10.1016/j.jpainsymman.2023.06.006.
Dhanak
M, Verma S, Hughes PG,
Ching AL, Lo A, Clay C, McKinney A, Frankenfield J. The Laboratory
Characterization of Fugitive Aerosol Emissions From a Standard Jet Nebulizer
With and Without a Filtered Mouthpiece. Cureus. 2023 Dec;15(12):e50611. Epub
2024/01/16. doi: 10.7759/cureus.50611. PMCID: PMC10788659
Cotton J, Bahner D, Prats
M. The lateral approach water bath: A novel method of ultrasound imaging of
the hand. Am J Emerg Med. 2023 Nov 15;77:164-168. Epub 20231115. doi:
10.1016/j.ajem.2023.11.005.
Awad E, Alinier G, Farhat
H, Rumbolt N, Azizurrahman A, Mortada B, Shami R. Provision of bystander CPR
for out-of-hospital cardiac arrest in the Middle East: a retrospective
gender-based analysis. Int J Emerg Med. 2023 Sep 26;16(1):63. Epub 20230926.
doi: 10.1186/s12245-023-00537-6. PMCID: PMC10523738
Haugland
H, Gamberini L, Hoareau GL, Haenggi M, Greif R, Brede JR. Resuscitative endovascular
balloon occlusion of the aorta in out-of-hospital cardiac arrest - A Delphi
consensus study for uniform data collection. Resusc Plus. 2023 Dec;16:100485.
Epub 20231011. doi: 10.1016/j.resplu.2023.100485. PMCID: PMC10583171
Kandula
VR, Taillac P, Nair
R, Balasubramanya MA. Transforming the emergency care scenario in India: A
make in India approach. Karnataka Medical Journal. 2023;46(1):24-27. doi:
10.25259/KMJ_5_2023.
Tilburg
CV, Paal P, Strapazzon G, Grissom CK, Haegeli P, Hölzl N, McIntosh S, Radwin M,
Smith WWR, Thomas S, Tremper B, Weber D, Wheeler AR, Zafren K, Brugger H.
Wilderness Medical Society Clinical Practice Guidelines for Prevention and
Management of Avalanche and Nonavalanche Snow Burial Accidents: 2024 Update.
Wilderness & Environmental Medicine. 2023;0(0):j.wem.2023.2005.2014. doi:
10.1016/j.wem.2023.05.014.
Luks
AM, Beidleman BA, Freer L, Grissom CK, Keyes LE, McIntosh
SE, Rodway GW, Schoene RB, Zafren K, Hackett
PH. Wilderness Medical Society Clinical Practice Guidelines for the
Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 Update.
Wilderness & Environmental Medicine. 2023;0(0):j.wem.2023.2005.2013. doi:
10.1016/j.wem.2023.05.013.
EXTERNAL PRESENTATIONS & RESEARCH NEWS
North American Congress of Clinical Toxicology (NACCT) 2023 Posters
Montreal, Quebec Canada
"Rivastigmine to Treat Anticholinergic Toxicity Following Drug Overdose"
Authors: Alyrene Dorey, MD; Michael Moss, MD, FAACT
Michael Moss MD, Brynne Hinchman PharmD, Joseph Lambson PharmD, Taylor Rhein PharmD, Julie Scott PharmD PhD, Paul Hinckley PharmD, Sawyer Wylie PharmD, Alyrene Dorey MD
VP for Research Large Infrastructure Funding Team (LIFT)
LIFT is designed to assist response teams for center, program, and large-scale grant opportunities. LIFT primarily provides grant writing support. At launch, LIFT will be led by AVPR Jakob Jensen. The inaugural unit consists of an Associate Director of Social Impact (Mercedes Ward) and three grant writers (Erin Meyer, Elizabeth Gerhart, and Osama Youssef). The unit will expand to include additional grant writers and graphic designers. LIFT does not charge for its services, but it does require a formal request for support. Researchers can submit LIFT requests HERE.
We anticipate that LIFT will receive a high volume of requests over the first few months of its operation. LIFT leadership will initially utilize the guidelines below to determine whether a request is a relevant fit to the mission of LIFT. We will continue to develop a refined set of criteria over the next several months.
Requests will be reviewed by the LIFT team and a decision will be communicated back to the requestor. LIFT does not have the bandwidth to support all requests. Key criteria for assessing requests include size and scope of the grant, support from corresponding colleges/branches/units, and long-term impact for the university. Requests for support can be made by the investigator, faculty, staff, or administration.
Requests for LIFT support should be submitted at least 12 weeks in advance of the sponsor's first required deadline.
Building Research Investigator Trainee Experiences (BRITE-IDEAS) VA HSR Fellowship
Building Research Investigator Trainee Experiences (BRITE-IDEAS) is an interprofessional post-graduate fellowship program. The mission of the program is to develop future VA leaders in health services research (HSR) and to support trainees to achieve independent research careers through mentorship, career development, and experiential learning that focuses on the core competencies of a Learning Healthcare System (LHS). Our vision is for a community of mentors, graduates, and trainees in HSR, with the research, leadership, and mentoring skills necessary to cultivate ongoing generations of VA scientists who constantly strive to improve the quality of delivery of care to our Veterans. It is a 2-year paid full-time position under the VA Office of Academic Affiliations (OAA).
