Previously described approaches for the alkylation of NH-sulfoximines typically rely either on transition metal catalysis, or the use of traditional alkylation reagents and strong bases. Herein, we report a straightforward alkylation of diverse NH-sulfoximines under simple Mitsunobu-type conditions, despite the unusually high pKa of the NH center.
C. J. Dodd, D. C. Schultz, J. Li, C. W. Lindsley and A. M. Bender, Org. Biomol. Chem., 2023, 21, 5181 DOI: 10.1039/D3OB00810J
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