Current and Future Applications of Fluorescence-Guided Surgery in Head and Neck Cancer

Estelle Martin; Marisa Hom; Lucas Mani; Eben L Rosenthal

doi:10.1016/j.soc.2022.07.001

Current and Future Applications of Fluorescence-Guided Surgery in Head and Neck Cancer

Surg Oncol Clin N Am. 2022 Oct;31(4):695-706. doi: 10.1016/j.soc.2022.07.001. Epub 2022 Sep 27.

Authors

Estelle Martin¹, Marisa Hom¹, Lucas Mani¹, Eben L Rosenthal²

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Preston Research Building 754, 2220 Pierce Avenue, Nashville, TN 37232, USA.
² Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Preston Research Building 754, 2220 Pierce Avenue, Nashville, TN 37232, USA. Electronic address: e.rosenthal@vumc.org.

PMID: 36243502
DOI: 10.1016/j.soc.2022.07.001

Abstract

Despite improvements in medical management of head and neck cancers, positive surgical margin rates have remained relatively unchanged in the past 30 years, emphasizing a need for improved intraoperative imaging and tumor visualization. This review provides a detailed summary on preoperative anatomic imaging techniques, nonspecific fluorescence imaging modalities, the recent emergence of tumor-targeting fluorophores for intraoperative imaging, and the future of fluorescence-guided surgery in head and neck cancer.

Keywords: Fluorescence-guided surgery; Near-infrared imaging; Nonspecific fluorophores; Positive surgical margins; Tumor-targeting fluorophores.

Publication types

Review

MeSH terms

Head and Neck Neoplasms* / surgery
Humans
Margins of Excision
Optical Imaging / methods
Surgery, Computer-Assisted* / methods