Regulatory Mechanism of Insulin Signaling in Diseases

Dear Colleagues,

This Special Issue on the regulatory mechanism of insulin signaling in diseases captures the ongoing challenges of insulin resistance. The Special Issue seeks to examine and identify novel biological processes that regulate insulin resistance in multiple tissues (e.g., adipose, pancreas, skeletal muscle, brain, cardiac muscle, and liver tissue). With this Special Issue, we aim to develop an integrative physiological perspective with a special focus on intricate signaling effectors that regulate cell-cell communication during insulin signaling and connectors that coordinate tissue specific responses. We will try to better understand insulin resistance, which in turn requires knowledge of normal insulin function and the pathophysiological effects of insulin resistance.

Insulin’s discovery has ignited interest in the study of the molecular mechanisms of cellular insulin action. Many fundamental cellular processes, including mitochondrial morphology, transfer of molecules across the mitochondrial endoplasmic reticulum contact space, trafficking of vesicles, regulation of gap junctions, mediating metabolic enzymes, activation of transcriptional factors, and auto degradation, are controlled by insulin. Importantly, insulin coordinates these complex processes to ensure glucose homeostasis in the body. More than that, recent literature has suggested that insulin also plays a role in maintaining mitochondrial function and regulating cell-cell communication. Insulin maintains homeostasis by regulating heart metabolism through the stimulation of glucose uptake.

Dr. Antentor Hinton
Prof. Dr. Sandra A. Murray
Guest Editors

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• insulin resistance
• insulin signaling
• gap junction
• cell-cell communication
• mitochondria
• mitochondria endoplasmic reticulum contacts