Tracing the evolutionary origins of antiviral immunity

PLoS Biol. 2024 Feb 6;22(2):e3002481. doi: 10.1371/journal.pbio.3002481. eCollection 2024 Feb.

Abstract

Animal and bacterial cells use shared mechanisms to defend against viruses. Analyzing 3 families of immune genes, a new study in PLOS Biology illuminates this evolutionary connection and traces the emergence of antiviral signaling across domains of life.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biological Evolution*
  • Signal Transduction
  • Viruses*

Grants and funding

This work was supported by the Burroughs Wellcome Fund (PJK), the Mathers Foundation (PJK), the National Institutes of Health (1DP2GM146250 to PJK), and the Cancer Research Institute (CRI4468 to PJK). The funders played no direct role in preparation of the manuscript or decision to publish.