The development of a cost effective, safe, and sustainable manufacturing process for crop protection active ingredients is essential for the successful commercialization of agrochemicals.
As part of our efforts of identifying process friendly synthetic technology to enable manufacturing route development, we are seeking a scalable, selective, and cost-effective process for mono-hydroxylation of readily available synthetic building blocks as shown in the figure below. Currently available methods often involve multiple synthetic steps, costly and non-scalable reagents, and long development timeline.
We invite public and private sector scientists to join in our efforts by submitting a proposal to develop and/or demonstrate a low-cost, scalable and sustainable process/method to enable the intended synthetic transformations.
We are seeking short, non-confidential proposals that describe a plan for a scalable, selective and cost-effective process for mono-hydroxylation of readily synthetic building blocks (see figure below).
Proposals should include: 1) Detailed method or plan on how we can develop and implement the process ; 2) Relevant literature or industrial application references; 3) A high-level cost estimate; and 4) A proposed development timeline.
Please exclude any proprietary and confidential information such as specific reagents, process conditions, specific enzymes and/or sequences.
- Scalable: can be scaled up to >Mton within a development time of 2 years
- Cost effective: less than $30 total conversion cost per kg of product at commercial scale (>100 Mton)
- A feasible path of isolating the desired product with a desirable purity
- Relevant literature or industrial application examples supporting the proposal
- For processes that involve biocatalyst or metal catalyst, commercial source and/or preparation method of the catalysts are desirable
- The proposed process adapts green chemistry principles: minimizing waste generation, using benign solvents, being less hazardous and atomic efficient
- Process presents any significant operation safety concern at commercial scale
- Process requires stoichiometric heavy metals
At Corteva we use the science of the lab and the land to maximize productivity and sustainability of the world's farmland.
We accomplish this through collaborating with thought leaders and innovators around the world to access and develop the most innovative technologies and rapidly deploying those through organizations that are good stewards of those technologies.
Join us and other thought leaders from around the world to stimulate the development of groundbreaking and sustainable solutions.
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