3i Initiative Year-End Highlights

Team Science Grant Updates
One of the primary goals of the 3i Initiative is to build interdisciplinary teams that are competitive for extramural multi-PI grants. To achieve this goal, the 3i Initiative uses a two-part cycle of a smaller team building grant process used to help start new collaborative teams. The follow-up cycle is our Program Project Planning Grant (3PG), which is used to help existing teams develop a competitive application for extramural funding. 

UU Collaborations
The primary goal of the 3i Initiative is to inspire and support collaborations between University of Utah researchers. Below are some actively collaborating groups: 

• R01AG080530 - Kelly Baron, Brian Baucom, Kevin Duff
  
• Mechanisms underlying adverse health outcomes following congenital viral infection (University of Utah 3i Initiative Program Project Planning grant) - Anna Beaudin, Mark Firpo, Albert Park
• HCI Experimental Therapeutics Program Pilot Project - Shreya Goel, Allison Payne, Henrik Odeen
• HCI Breast and Gynecologic Cancer Center Pilot Project - Shreya Goel, Allison Payne, Henrik Odeen
• Mouse RIpk2 project - Mick Jurynec, David Grunwald
• Mouse rotator repair project - Mick Jurynec, Robert Tashjia
• Development of clinical decision tools for management of diarrhea of children in high and low resource settings - R01AI135114 Renewal - Daniel Leung, Ben Haaland, Andy Pavia, Ben Brintz, Sharia Ahmed, Melissa Watt, Per Gesteland
  
• A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence (Nucleic Acids Res. 2022) - Matt Mulvey, Mike Howard, Vahe Bandarian
  
• Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases (Blood Adv.) - Matt Mulvey, Diane Ward
• The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis (PLoS Pathog.) - Matt Mulvey, Janis Weis
  
• Global metabolomics profiling, dietary factors, and colorectal cancer risk in the NIH-Consortium of Metabolomics Studies (COMETS) - R03CA270473 - Jennifer Ose, Mary Playdon
• Utah Grand Challenges - Jennifer Ose, Jeffrey Yap, Matthew Covington
  
• Department of Defense, Congressionally Directed Medical Programs (CDMRP) Spinal Cord Injury Research Program (SCRIP) Translational Research Award - Shawn Owen, Matthew Mulvey, Jaclyn Winter, Jessica Brown, Sara Lenherr
• Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS (Front Immunol) - Vincente Planelles, Chris Hill, Heidi Schubert
• Rapid and Affordable Point-of-care Test for Detection of SARS-Cov-2-Specific Antibodies Based on Hemagglutination and Artificial Intelligence-Based Image Interpretation (Sci Rep.) - Vincente Planelles, Hans Haecker, Vanessa Redecke
• Interferon alpha-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation (Haematologica) - Vincente Planelles, Paul Bray
• HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs (Virulence) - Vincente Planelles, Lou Barrows
• Evaluation of a Surrogate ELISA- Based Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) cPass Neutralization Antibody Detection Assay and Correlation with IgG Commercial Serology Assays (Arch Pathol Lab) - Vincente Planelles, Julio Delgado
• Pharmacologic control of homeostatic and antigen-driven proliferation to target HIV-1 persistence (Biochem Pharmacol.) - Vincente Planelles, Adam Spivak
  
• Metabolic Consequences of Genetic Variation in Malaria Parasites on the Protective Effect of Human Sickle Cell Trait (3i Team-Building Grant) - Paul Sigala, Ellen Leffler, James Cox
  
• Understanding Sodium-Dependent Renal Immune Cell Activation and Migration- Microfluidic Modeling and Kidney Chips (National Kidney Foundation of Utah & Idaho) - Brandi Wynne, Jay Kim
  

New 3i Fellows
Thanks to an anonymous donor, the 3i Initiative has been able to award graduate student fellowships in inflammation research and emerging microbial threats. This fellowship seeks to train the next generation of inflammation researchers while advancing today's scientific knowledge in tangible ways.

Second Year 3i Fellows

Links to Faculty Profiles

• Gianna Hammer - Pathology
• Tyler Starr - Biochemistry
• Katharine Walter - Internal Medicine/Epidemiology
  

Featured Awards
Congratulations to the following 3i researchers on their awards this past year! 

Featured Funded Grants

3i Initiative Investigators were awarded over 185 grants from NIH extramural grants during the last fiscal year. Below is a shortlist of featured funded grants from all sources.  

• Anna Beaudin - 2021-2023 NHLBI R21-HL157794. " Regulation of hematopoietic stem cell function by prenatal folate status."
• Paul Bray - 07/01/21-06/30/22 ASH Bridge Grant
• Ram Gouripeddi - The Aging Exposome: Characterizing Bidirectional Effects of Exposures and Aging, National Academy of Medicine
• Shreya Goel - Research Instrumentation Fund from the University of Utah Office of the Vice President for Research for a novel small animal imaging scanner: Multispectral Optoacoustic Tomography (MSOT)
• Mollie Cummins - PCORnet RECOVER EHR, Participating Site, NIH NHLBI, Subcontract to Weill-Cornell
• Gianna Hammer - Burroughs Wellcome Fund,  2021 Investigators In The Pathogenesis Of Infectious Disease
  
• Mick Jurynec - 1R21AG063534-01A1 [NIH/NIA] Jurynec/Grunwald (MPI) 09/11/2020-05/31/2022 Establishing a New Genetic Mouse Model of Osteoarthritis
• Mick Jurynec - 707634  [ANRF] Jurynec (PI) 09/01/2020-08/31/2022. Analysis of the NOD-RIPK2 Signaling Pathway in Osteoarthritis
  
• Daniel Leung - Renewal of R01AI135114. - Development of clinical decision tools for the management of diarrhea of children in high and low resource settings
• Daniel Leung - R21HD109819A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh
  
• Brandi M. Wynne - O’Brien Kidney Research Core Center (P30 DK079307) Pilot Grant
  University of Pittsburgh “Renal Dendritic Cell Intraluminal Sodium Sampling Increases Interleukin 6” 8/1/2020-7/30/2022
  
• Matthew Mulvey - SC210103, Combating Multi-Drug Resistant Urinary Tract Infections in Spinal Cord Injury Patients. DoD Spinal Cord Injury Research Program (SCIRP) Translational Research Award. Sept 1, 2022 – Aug 31, 2025.
• Matthew Mulvey - T32 AI055434, Training Program in Microbial Pathogenesis. NIH/NIAID, 08/01/21–07/31/26.
  
• Shawn Owen - Department of Defense, Congressionally Directed Medical Programs (CDMRP) Spinal Cord Injury Research Program (SCRIP) Translational Research Award
• Ryan O'Connell & Micah Drummond - 1R01AG076075-01A1[NIH/NIA] - Regulation of macrophage metabolism in aged muscle during recovery
• Ryan O'Connell & Micah Drummond- 1R01AG079477-01[NIH/NIA] - MicroRNA regulation of chronic inflammation during aging 
  
• Jarrod S. Johnson - U54 CHEETAH (led by Wes Sundquist) along with other investigators at the U: Janet Iwasa, Nels Elde, Michael Kay, and Chris Hill
  
• Kathie Supiano - State of Utah-Department of Health & Human Services COVID-Recovery and COVID-Grief: Support Programs for Utahns impacted by COVID-19
  
• Alessandro Venosa - NIEHS Outstanding New Environmental Scientist (ONES) Award - Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis
  

Investigator Media & Talk Highlights

See all 3i Initiative press releases here

Featured Publications

3i Initiative faculty have published over 1,000 peer-reviewed articles in the past year.  To see a full list, follow this link. Below is a list of some featured publications: 

• Kempker JA, Martin GS, Rondina MT, Cannon-Albright LA.  Evidence for an inherited contribution to sepsis susceptibility among a cohort of U.S. Veterans. Crit Care Explor 2022 JN 11;4(1):E0603.
• Hernandez GE, Ma F, Martinez G, Firozabadi N, Salvador J, Juang LJ, Leung J, Zhao P, Lopez DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML. Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. (2021). Nature Cardiovascular Research. In press.
• Otsuka KS, Neilson C, Firpo MA, Park AH, Beaudin AE.  Early life inflammation and the developing hematopoietic and immune systems: the cochlea as a sensitive indicator of disruption.  (2021) Cells.10, 3596.
• Lin Y, Perovanovic J, Kong Y, Igyarto BZ, Zurawski S, Tantin D, Zurawski G, Bettini M, Bettini ML. Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes. Diabetes. 2022 Aug 1;71(8):1735-1745. doi: 10.2337/db21-1069. PubMed PMID: 35622068.
• Kong Y, Jing Y, Allard D, Scavuzzo MA, Sprouse ML, Borowiak M, Bettini ML, Bettini M. A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes. Eur J Immunol. 2022 Jul;52(7):1158-1170. doi: 10.1002/eji.202149690. Epub 2022 Apr 22. PubMed PMID: 35389516.
• Jing Y, Kong Y, McGinty J, Blahnik-Fagan G, Lee T, Orozco-Figueroa S, Bettini ML, James EA, Bettini M. T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope. Diabetes. 2022 May 1;71(5):1012-1022. doi: 10.2337/db21-0993. PubMed PMID: 35179565; PubMed Central PMCID: PMC9044133.
• Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE. Thymic development of gut-microbiota-specific T cells. Nature. 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1. Epub 2021 May 12. PubMed PMID: 33981034; PubMed Central PMCID: PMC8323488.
• Bettini M, Bettini ML. Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes. Diabetes. 2021 Jun;70(6):1211-1219. doi: 10.2337/dbi18-0058. Epub 2021 May 20. Review. PubMed PMID: 34016597; PubMed Central PMCID: PMC8275894.
• Loher P, Karathanasis N, Londin E, Bray P, Pliatsika V, Telonis AG, Rigoutsos I.  IsoMiRmap – fast, deterministic, and exhaustive mining of isomiRs from short RNA-seq datasets.  Bioinformatics 2021 37(13):1828-1838. doi: 10.1093/bioinformatics/btab016. PMID: 33471076
• Ross JE*, Zhang BM*, Lee K, Mohan S, Branchford BR, Bray P, Dugan SN, Freson K, Heller PG, Kahr WHA, Lambert MP, Luchtman-Jones L, Luo M, Botero JP, Rondina M, Ryan G, Westbury S, Bergmeier W, Di Paola J, on behalf of the ClinGen Platelet Disorder Variant Curation Expert Panel. Specifications of the ACMG/AMP Variant Curation Guidelines for ITGA2B/ITGB3: Recommendations by ClinGen Platelet Disorder Variant Curation Expert Panel.  Blood Adv 5(2): 414–431, 2021.  doi: 10.1182/bloodadvances.2020003712. PMID: 33496739
• Abou-Ismail MY, Rodgers GM, Bray PF, Lim MY.  Acquired von Willebrand syndrome in monoclonal gammopathy - A scoping review on hemostatic management.  Res Prac Thromb Haemost 5(2):356-365, 2021. doi: 10.1002/rth2.12481. PMID: 33733035
• Bhatlekar S, Jacob S, Manne BK, Guo l, Denorme F, Tuglokova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, O’Connell RM, Bray PF.  Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet Count without altering platelet function.  Blood Cells, Molec and Dis 2021 92:102624. doi: 10.1016/j.bcmd.2021.102624. PMID: 34775219
• Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, Bray PF, Rowley.  CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.  Blood Adv. 2021 May 11;5(9):2362-2374. doi: 10.1182/bloodadvances. 2020004112.PMID: 33944898 
• Bhatlekar S, Jacob S, Tugolukova E, Manne BK, Kosaka Y, Loher P, O’Connell RM, Planelles V, Rondina MT, Rigoutsos I, Bray PF.  Interferon alpha-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation. Haematologica 2022; 107:558-561. doi: 10.3324/haematol.2021.279864.PMID: 34758609
• Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA.  Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand.  Blood Adv, 2022 Apr 12;6(7):2303-2308. doi: 10.1182/bloodadvances.2021006133
• Rodgers GM, Ward JH, Bray PF. 80 Years of Clinical Hematology.  Brit J Haematol, 2022. Jul 8. doi: 10.1111/bjh.18346. Online ahead of print. PMID: 35802037.
• Mistry S, Gouripeddi R, Facelli JC, Facelli JC. Data-driven identification of temporal glucose patterns in a large cohort of nondiabetic patients with COVID-19 using time-series clustering. JAMIA Open. 2021 Jul 15;4(3):ooab063. doi: 10.1093/jamiaopen/ooab063. Erratum in: JAMIA Open. 2021 Sep 24;4(3):ooab080. PMID: 34409266; PMCID: PMC8364667.
• Riches NO, Gouripeddi R, Payan-Medina A, Facelli JC. K-means cluster analysis of cooperative effects of CO, NO2, O3, PM2.5, PM10, and SO2 on incidence of type 2 diabetes mellitus in the US. Environ Res. 2022 Sep;212(Pt B):113259. doi: 10.1016/j.envres.2022.113259. Epub 2022 Apr 20. PMID: 35460634; PMCID: PMC9413686.
• Riches NO, Gouripeddi R, Payan-Medina A, Facelli JC. K-means cluster analysis of cooperative effects of CO, NO2, O3, PM2.5, PM10, and SO2 on incidence of type 2 diabetes mellitus in the US. Environ Res. 2022 Sep;212(Pt B):113259. doi: 10.1016/j.envres.2022.113259. Epub 2022 Apr 20. PMID: 35460634; PMCID: PMC9413686.
• Jurynec MJ, Gavile CM, Honeggar M, Ma Y, Veerabhadraiah SR, Novak KA, Hoshijima K, Kazmers NH, Grunwald DJ. The NOD/RIPK2 signaling pathway contributes to osteoarthritis susceptibility. Ann Rheum Dis. 2022 Jun 22;annrheumdis-2022-222497. doi: 10.1136/annrheumdis-2022-222497. Online ahead of print.
• Miller M, Kazmers NH, Chalmers PN, Tashjian RZ, Jurynec MJ. Supraspinatus Rotator Cuff Repair: A mouse model and technique. Arthrosc Tech. 2021 Jul 13;10(8):e1949-e1954. doi: 10.1016/j.eats.2021.04.023. eCollection 2021 Aug
• Tashjian RZ, Kazmers NH, Epperson RT, Honeggar M, Ma Y, Chalmers PN, Williams DL, Jurynec MJ. The Effect of Estrogen-Like Compound on Rotator Cuff Tendon Healing in a Murine Model. J Orthop Res. 2021 Feb 2. doi: 10.1002/jor.25000. Online ahead of print. PMID: 33533088
• Jensen O, Trivedi S, Meier JD, Fairfax KC, Hale JS, Leung DT. A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa. Sci Immunol. 2022 Jan 14;7(67):eabe8931. doi: 10.1126/sciimmunol.abe8931. Epub 2022 Jan 14. PMID: 35030034; PMCID: PMC9001248.
• Wynne BM, Samson TK, Moyer HC, van Elst HJ, Moseley AS, Hecht G, Paul O, Al-Khalili O, Gomez-Sanchez C, Ko B, Eaton DC, Hoover RS. Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron. Am J Physiol Cell Physiol. 2022 Nov 1;323(5):C1512-C1523. doi: 10.1152/ajpcell.00272.2021. Epub 2022 Aug 1. PMID: 35912993; PMCID: PMC9662807.
• Fleming BA, Blango MG, Rousek AA, Kincannon WM, Tran A, Lewis AJ, Russell CW, Zhou Q, Baird LM, Barber AE, Brannon JR, Beebout CJ, Bandarian V, Hadjifrangiskou M, Howard MT, Mulvey MA. A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence. Nucleic Acids Res. 2022 Jul 22;50(13):7570-7590. doi: 10.1093/nar/gkac116. PMID: 35212379; PMCID: PMC9303304
• Hancock SJ, Lo AW, Ve T, Day CJ, Tan L, Mendez AA, Phan MD, Nhu NTK, Peters KM, Richards AC, Fleming BA, Chang C, Ngu DHY, Forde BM, Haselhorst T, Goh KGK, Beatson SA, Jennings MP, Mulvey MA, Kobe B, Schembri MA. Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathog. 2022 Jun 14;18(6):e1010582. doi: 10.1371/journal.ppat.1010582. PMID: 35700218; PMCID: PMC9236248.
• Ose J, Gigic B, Hardikar S, Lin T, Himbert C, Warby CA, Peoples AR, Lindley CL, Boehm J, Schrotz-King P, Figueiredo JC, Toriola AT, Siegel EM, Li CI, Ulrich A, Schneider M, Shibata D, Ulrich CM. Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study. Cancer Epidemiol Biomarkers Prev. 2022 Aug 2;31(8):1650-1660. doi: 10.1158/1055-9965.EPI-22-0092. PMID: 35667092; PMCID: PMC9509698.
• Yao, Z., Drecun, L., Aboualizadeh, F. et al. A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies. Nat Commun 12, 1806 (2021). https://doi.org/10.1038/s41467-021-22102-6
• Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D'Orso I, Hill CP, Planelles V. 2021. Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal. mBio 12:e0109821. PMID: 34154414
• Sarabia I, Novis CL, Macedo AB, Takata H, Nell R, Kakazu JC, Furler RL, Shakya B, Schubert HL, Hill CP, DePaula-Silva AB, Spivak AM, Trautmann L, Planelles V, Bosque A. 2021. Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS. Front Immunol 12:682182. PMID: 34194436. PMCID: PMC8236643
• Innis EA, Levinger C, Szaniawski MA, Williams ESCP, Alcamí J, Bosque A, Schiffer JT, Coiras M, Spivak AM, Planelles V. Pharmacologic control of homeostatic and antigen-driven proliferation to target HIV-1 persistence. Biochem Pharmacol. 2021. PMID: 34715067. PMCID: PMC8629953
• Larragoite ET, Nell RA, Martins LJ, Barrows LR, Planelles V, Spivak AM. Histone deacetylase inhibition reduces deleterious cytokine release induced by ingenol stimulation. Biochem Pharmacol. 195:114844. 2022. PMID: 34801521. PMCID: PMC8712404.
• Martins LJ, Szaniawski MA, Williams ESCP, Coiras M, Hanley TM, Planelles V. HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages. Pathogens 2022 11:163. PMID 35215107. PMCID: PMC8878269
• Galán M, Vigón L, Fuertes D, Murciano-Antón MA, Casado-Fernández G, Domínguez-Mateos S, Mateos E, Ramos-Martín F, Planelles V, Torres M, Rodríguez-Mora S, López-Huertas MR, Coiras M. Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers. Front Immunol. 2022;13:848886. PMID: 35401523. PMCID: PMC8990790.
• Dickey LL, Martins LJ, Planelles V, Hanley TM. HIV-1-induced type H18I IFNs promote viral latency in macrophages. J Leukoc Biol. 2022, doi: 10.1002/JLB.4MA0422-616R. PMID: 35588262; PMCID in progress.
• Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I. ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Nat Commun. 2022 Mar 1;13(1):1109. doi: 10.1038/s41467-022-28772-0. PMID: 35232997. PMCID: PMC8888757.
• Falekun S, Sepulveda J, Yasaman JA, Park H, Wohlschlegel JA, and Sigala PA. “Divergent Acyl Carrier Protein Decouples Mitochondrial Fe-S Cluster Biogenesis from Fatty Acid Synthesis in Malaria Parasites” eLife (2021) 10:e71636. PMID: 34612205
• Okada M, Rajaram K, Swift RP, Mixon A, Maschek JA, Prigge ST, and Sigala PA. “Critical Role for Isoprenoids in Apicoplast Biogenesis by Malaria Parasites.” eLife (2022) 11:e73208. PMID: 35257658
• Okang, E., Aaron, S., Supiano, K. P. & Osman, A. (2022). Aging Services Workers in the Pandemic: Voiced Experience of Senior Center Staff & Case Workers. Gerontology and Geriatric Medicine. 8, 1-5. doi: 10.1177/233372/4221116470
• Papamichael K, Jairath V, Zou G, Cohen B, Ritter T, Sands B, Siegel C, Valentine J, Smith M, Vande Casteele N, Dubinsky M, Cheifetz A. Proactive infliximab optimisation using a pharmacokinetic dashboard versus standard of care in patients with Crohn's disease: study protocol for a randomised, controlled, multicentre, open-label study (the OPTIMIZE trial). BMJ Open. 2022 Apr 1;12(4):e057656. doi: 10.1136/bmjopen-2021-057656.PMID: 35365535 
• Tse CS, Van Citters AD, Ricci B, Freundlich NZ, Lee M, Shah SA, Melmed GY, Siegel CA, van Deen WK; IBD Qorus. Identifying and Predicting the Goals and Concerns Prioritised by Individuals with Inflammatory Bowel Disease. J Crohns Colitis. 2022 Mar 14;16(3):379-388. doi: 10.1093/ecco-jcc/jjab142.PMID: 34350943
• Peyrin-Biroulet L, Hart A, Bossuyt P, Long M, Allez M, Juillerat P, Armuzzi A, Loftus EV Jr, Ostad-Saffari E, Scalori A, Oh YS, Tole S, Chai A, Pulley J, Lacey S, Sandborn WJ; HICKORY Study Group. Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial. Lancet Gastroenterol Hepatol. 2022 Feb;7(2):128-140. doi: 10.1016/S2468-1253(21)00298-3. Epub 2021 Nov 17.PMID: 34798039
• Rubin DT, Dotan I, DuVall A, Bouhnik Y, Radford-Smith G, Higgins PDR, Mishkin DS, Arrisi P, Scalori A, Oh YS, Tole S, Chai A, Chamberlain-James K, Lacey S, McBride J, Panés J; HIBISCUS Study Group. Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials. Lancet Gastroenterol Hepatol. 2022 Jan;7(1):17-27. doi: 10.1016/S2468-1253(21)00338-1. Epub 2021 Nov 17.PMID: 34798036
• Vermeire S, Lakatos PL, Ritter T, Hanauer S, Bressler B, Khanna R, Isaacs K, Shah S, Kadva A, Tyrrell H, Oh YS, Tole S, Chai A, Pulley J, Eden C, Zhang W, Feagan BG; LAUREL Study Group. Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study.  Lancet Gastroenterol Hepatol. 2022 Jan;7(1):28-37. doi: 10.1016/S2468-1253(21)00295-8. Epub 2021 Nov 17.PMID: 34798037
• Pozdnyakova V, Botwin GJ, Sobhani K, Prostko J, Braun J, Mcgovern DPB, Melmed GY, Appel K, Banty A, Feldman E, Ha C, Kumar R, Lee S, Rabizadeh S, Stein T, Syal G, Targan S, Vasiliauskas E, Ziring D, Debbas P, Hampton M, Mengesha E, Stewart JL, Frias EC, Cheng S, Ebinger J, Figueiredo JC, Boland B, Charabaty A, Chiorean M, Cohen E, Flynn A, Valentine J, Fudman D, Horizon A, Hou J, Hwang C, Lazarev M, Lum D, Fausel R, Reddy S, Mattar M, Metwally M, Ostrov A, Parekh N, Raffals L, Sheibani S, Siegel C, Wolf D, Younes Z. Decreased Antibody Responses to Ad26.COV2.S Relative to SARS-CoV-2 mRNA Vaccines in Patients With Inflammatory Bowel Disease. Gastroenterology. 2021 Dec;161(6):2041-2043.e1. doi: 10.1053/j.gastro.2021.08.014. Epub 2021 Aug 12.PMID: 34391771
• Lewis JD, Sandler RS, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson JS, Suskind DL, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen BL, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group. A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease. Gastroenterology. 2021 Sep;161(3):837-852.e9. doi: 10.1053/j.gastro.2021.05.047. Epub 2021 May 27.PMID: 34052278 
• Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021 Aug;596(7870):114-118. doi: 10.1038/s41586-021-03722-w. Epub 2021 Jul 14.PMID: 34262174
• Nguyen J, Deering-Rice CE, Armstrong BS, Massa C, Reilly CA, Venosa A. Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung. Toxicol Sci. 2022 Jul 22:kfac074. doi: 10.1093/toxsci/kfac074. Epub ahead of print. PMID: 35866636
• Nguyen J, Armstrong BS, Cowman S, Tomer Y, Veerabhadraiah SR, Beers MF, Venosa A. Immunophenotyping of Acute Inflammatory Exacerbations of Lung Injury Driven by Mutant Surfactant Protein-C: A Role for Inflammatory Eosinophils. Front Pharmacol. 2022 Apr 27;13:875887. doi: 10.3389/fphar.2022.875887. PMID: 35571100; PMCID: PMC9094740
• Golden TN, Venosa A, Gow AJ. Cell Origin and iNOS Function Are Critical to Macrophage Activation Following Acute Lung Injury. Front Pharmacol. 2022 Jan 25;12:761496. doi: 10.3389/fphar.2021.761496. PMID: 35145401; PMCID: PMC8822172
• Venosa A, Smith LC, Gow AJ, Zarbl H, Laskin JD, Laskin DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021 Jul 15;423:115569. doi: 10.1016/j.taap.2021.115569. Epub 2021 May 7. PMID: 33971176; PMCID: PMC8496734.
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