Heating Things Up…While Keeping Our Cool!
Heating Things Up…While Keeping Our Cool!
 Heating Things Up…While Keeping Our Cool!
STM Newsletter - December 2020
Updates: Stay safe and warm this winter by joining your fellow STM colleagues in the first annual exercise challenge! 
Perhaps you are familiar with the positive impacts that exercise and hyperthermia have on improving your immune response? 
Hyperthermia and exercise can also improve your brain!:
Repeated hyperthermia exposure increases circulating Brain Derived Neurotrophic Factor levels which is associated with improved quality of life, and reduced anxiety: A randomized controlled trial https://doi.org/10.1016/j.jtherbio.2019.102482

Sign up to participate in this fun virtual event in January and February.
Challenge your mentor, your mentees, your colleagues, or yourself.  Log the time and type of exercise you perform weekly.  Walk, run, bike, row, climb steps, or lift weights; do any exercise that makes you feel good! Then tell us about it!

To sign up, email: stm@allenpress.com
Cost: $30, which includes an STM t-shirt
All participants will also be entered in a raffle to win an STM themed prize.
To challenge a fellow STM member, ask them and email nlevi@wakehealth.edu to let STM know what challenge has been accepted.
The full list of challenges will be released in next month's newsletter.
Current challenges:
Krishna Ramajayam -> Nicole Levi: 250 kettlebell swings and 10 mi walking per week
Raquel Martinez -> Rajiv Chopra: 30km of biking per week
Nicole Levi -> Mark Dewhirst: 15 mi walking per week
Rajiv Chopra -> Raquel Martinez: 1 hr capoeira (Brazilian martial arts) and 3 hrs yoga per week
This 2 month long virtual challenge event will culminate in a virtual symposium in March on participant accomplishments and scientific content on exercise, thermal medicine and the immune response.  Proceeds from the event will support junior investigators and early career STM memberships.
Updates: The Minorities and Women in Science Committees Mentorship Program
Junior scientists: Do you want to learn more about how to advance your careers in academia or industry?  Having a mentor can help you find your path! Join senior STM members virtually for 1 on 1 monthly mentoring.
The initiative is open to ALL members of the Society regardless of background; however, the Committees strongly encourage female and minority members to take part.
Senior members interested in serving as mentors should contact Rajiv Chopra (rajiv.chopra@utsouthwestern.edu)
Junior members interested in receiving mentorship should contact Anjan Motamarry (amotamarry@mgh.harvard.edu
Membership - Support STM during this critical time
Don’t let your STM membership lapse!  Even though we are not having an in-person meeting until next year, STM is planning a series of virtual symposia and webinars to spread our knowledge, develop new ideas, and engage with one another.  Now is a critical time to show your support for STM and rebuild your connections.
Renew your membership here for 2021: https://www.thermaltherapy.org/ebusSFTM/MEMBERSHIP.aspx
Membership in The Society for Thermal Medicine is open to anyone interested in the study of thermal medicine.
Membership rights and privileges include:
  • Participating in society elections
  • Committee service
  • Access to restricted “members-only” areas of the STM website
  • Discount on ICHO 2021 registration fees
  • Free registration to all STM webinars/mini-symposia
  • A 30% discount on IJH article submission fees
  • Complementary sponsorship of 2 junior investigators

In conjunction with renewing your STM membership start the New Year off on the right foot: Participate in the STM virtual exercise challenge!

Virtual Symposia
One of the best ways that STM members can come together is to renew their membership and get ready to participate in the upcoming monthly webinars and symposia. Virtual events will be interactive in real-time so STM members can engage with the speakers and foster good dialogue. Presentations will also be recorded so all members can enjoy this free content.  STM is excited for the new webinar format that will allow for thermal medicine researchers from all across the world to actively participate!
We apologize to our members that there has been a temporary set-back with posting the content from the previous virtual sessions on the STM webpage. Until the issue can be resolved, please contact nlevi@wakehealth.edu or rfernandes@email.gwu.edu for access to the content from previous STM virtual sessions.
Upcoming virtual events include:

February 10th, 2021 (11am-1pm EST): STM will partner with the American Society for Laser Medicine and Surgery (ASLMS) for a joint symposium on Cell stress pathways and energy-based devices. This event will be offered for CME credit through ASLMS. 
- Dieter Manstein and Nicole Levi: Welcome of STM and ASLMS members 
- Michael Graner: Heat stress and heat shock proteins
- John Pearce: Biological heat transfer
- Erik Cressman: Energy based devices
- Betsy Repasky: Body temperature and thermoregulation: Some basics on 
physiology and immunology
- Steve Fiering: Anti-tumor immune responses
Registration is free for active STM members.
Please email the STM Business Office at stm@allenpress.com if you would like to register for this event. 
March (date and time TBD): Virtual symposium on the benefits of exercise induced hyperthermia
- Mark Dewhirst and more to be announced soon!
REGISTRATION DETAILS: This event is FREE to STM members. Non-STM members are encouraged to renew their membership and join the webinar for free, although they may also participate for $50. 

Please email the STM Business Office at stm@allenpress.com if you would like to register for this event.

April (date and time TBD): STM and ASLMS will partner for the second joint symposium.  The topic for this event is Photothermal Nanoparticles

- Robert Griffin: Gold photothermal nanoparticles for cancer and bacteria
- Kaushal Rege: Gold nanoparticles for wound sealing
- Nicole Levi: Photothermal polymer nanoparticles
- Rohan Fernandes: Prussian blue nanoparticles and immune responses
- Kanav Khosla: Using photothermal nanoparticles for warming cryopreserved tissues
- Ravi Singh: Photothermal sensitization of breast cancer to radiation

Registration is free for active STM members.
Please email the STM Business Office at stm@allenpress.com if you would like to register for this event. 
Connect with us!
If you have suggestions for how we can better improve STM as we delve together into these new plans, please reach out, and let us know:
Call for Committee Members
STM is seeking your help in contributing to editing the monthly newsletter.  This would be an opportunity to contribute and build your CV. Inquire with Nicole Levi-Polyachenko, nlevi@wakehealth.edu.
STM now has two new committees that would welcome the participation of junior and established members:
- Minorities in STM (chaired by Rajiv Chopra and Raquel Martinez) and
- Women in STM (chaired by Nicole Levi and Colleen Crouch)
We encourage you to become more involved in STM through participation in these committees! Contact stm@allenpress.com to sign up.
STM now has a new member's only jobs section on our website, for both industry and academic positions. Please send any jobs wanted or job postings to stm@allenpress.com and we will add them to the website. Please note, in order to access the jobs page you must be signed in as an active STM member. Please contact us if you have any questions/concerns.
International Journal of Hyperthermia Updates
Do you like learning more about Thermal Medicine? Remember that STM is the official sponsor for the International Journal of Hyperthermia.

STM members receive a valuable 30% discount on publishing charges.  Now is a great time to work from home and write your manuscripts for submission to IJH!  IJH is on track to receive a record number of submissions this year and its impact factor continues to increase annually (3.589 for 2018).  
IJH is always interested in innovative ideas to increase the breadth of the journal and we strongly hope that the special issues venue will help in the expansion. We are open to additional Industry-Sponsored or Foundation sponsored Special Issues. Please let us know if you have an idea for one!
We are excited to announce that IJH has an Open Call for papers on: Image guided therapies for treatment of colorectal cancer metastases
This Special Issue will focus on use of image guided therapies for treatment of colorectal cancer metastases.  A very prestigious list of key authors have agreed to participate.  We invite you to submit a paper on the broad subject of "Image guided therapies for treatment of colorectal cancer metastases", for potential inclusion within the Special Issue, pending successful peer review.
Listed below are the invited authors and manuscript titles that will be included.
- Matthew Callstrom: Mayo Clinic, “Ablation for Oligometastatic CRC disease in non-hepatic/non-pulmonary sites”
Thierry DeBaere: Institute Gustave Roussy, “Ablation in Hepatic and Pulmonary oligometastatic disease”
- Bruno Odisio and Constantinos Sofocleous: MD Anderson Cancer Center & Memorial Sloan Kettering Cancer Center, “Liver metatastases: Rationale, indications and outcomes of thermal ablation as a local curative therapy: When should it be used instead of resection”.
- Raj Narayanan: Baptists Health - Miami Cardiac and Vascular Institute, “IRE for CRC Liver Metastases: Indications and Outcomes”
- Robert Lewandowski: Northwestern University, “Y90 radiation segmentectomy in CRC metastatic disease: Rationale, Indications and Outcomes”
- Ali Hosni Abdalaty and Laura Dawson: Princess Margaret Cancer Center,  “IMRT/SBRT/Proton therapy: Indications and evidence for treatment of CRC metastases”
- Juan Camacho, Stephen B. Solomon: Memorial Sloan Kettering Cancer Center, "Pulmonary Metastases: Rationale, Indications and Outcomes  of thermal ablation”
- Stephen Hunt: University of Pennsylvania, “Molecular Imaging, a valuable tool in Management of Colorectal Metastatic Disease by Interventional Oncology”.
View the call for papers and submit your manuscript HERE.
Featured International Journal of Hyperthermia Articles
Effects of stereotactic radiofrequency thermocoagulation in the globus pallidus internus on refractory tic disorders
Yu-Hui Li, Kai Zhao, Mei-Qing Wang, Jing Wang & Bu-Lang Gao 
To investigate the effect of stereotactic radiofrequency thermocoagulation in the globus pallidus internus on refractory tic disorders.
Materials and methods
Forty patients with refractory tic disorders were enrolled between January 2015 and July 2017 to experience stereotactic radiofrequency thermocoagulation in the globus pallidus internus. All clinical data, Yale Global Tic Severity Scale (YGTSS) scores, serum dopamine (SDA), and 5-hydroxytryptamine (5-HT) were analyzed.
Radiofrequency thermocoagulation was successfully performed in all patients. Periprocedural complications occurred in two patients (5.0%), one with fever (2.5%) and one with a urination disorder (2.5%); both returned to normal after treatment. After 12 months of follow-ups, excellent improvement was exhibited in 18 patients (45.0%), marked improvement in 10 (25.0%), good improvement in 9 (22.5%), and invalid in 3 (7.5%), with a total efficacy rate of 92.5% (37/40). Twenty-eight patients (70%) showed excellent or marked improvement without additional treatment after surgery. YGTSS scores were significantly (p < 0.05) decreased after compared with before thermocoagulation. SDA was significantly (p < 0.05) decreased 6 months (80.78 ± 18.82 ng/ml) and 12 months (75.65 ± 15.23 ng/ml) after compared with before (125.63 ± 35.26 ng/ml) surgery, whereas 5-HT was significantly (p < 0.05) increased 6 months (58.93 ± 16.88 ng/ml) and 12 months (62.63 ± 15.21 ng/ml) after compared with before (35.62 ± 3.41 ng/ml) surgery.
Stereotactic radiofrequency thermocoagulation can be safely applied in the globus pallidus internus to treat refractory tic disorders, resulting in significant tic symptom relief and a decrease in SDA but increase in 5-HT.
Macrophages and brown adipocytes cross communicate to modulate a thermogenic program following methamphetamine exposure
Manuel Sanchez-Alavez, Nikki Bortell, Liana Basova, Fahumiya Samad & Maria Cecilia Garibaldi Marcondes
Hyperthermia is a potentially lethal side-effect of Methamphetamine (Meth), a stimulant drug. Activation of non-shivering thermogenesis in brown adipose tissue (BAT) is partly responsible for Meth-induced rise in temperature, with contributing sympathetic neurotransmitters, such as norepinephrine (NE), and reactive oxygen species (ROS). However, the mechanisms controlling the development of a molecular thermogenic program in brown adipocytes (BA) following Meth are unknown. We hypothesize that Meth and NE affect BAT cells, BA and macrophages, to modify their physiology and interactions, with consequences to thermogenic genes. We also hypothesize that ROS play a critical role in signaling transcription of thermogenic genes and their regulatory components. Using primary BA and macrophage cultures, we measured Meth and NE interference with physiological and phenotypic measures that are relevant to thermogenesis in BAT. Meth caused both BA and macrophages to decrease mitochondrial maximal capacity and increase ROS. In BA, the thermogenic genes UCP1, PPARc, PGC1a and GADD45c were transcriptionally increased by Meth in a ROS-dependent manner. In macrophages, Meth increased oxidative stress response and caused a predominance of M2 subset markers. BA transcriptional changes in response to Meth and NE were significantly controlled by macrophages. The results suggest that BA and macrophages respond to Meth and NE, with effects on mitochondrial functions and transcription of genes involved in thermogenesis. ROS-dependent signals in BA and cellular interactions between BA and macrophages synergize to regulate the BAT environment and control critical pathways leading to Meth-hyperthermia.
Evaluation of a numerical simulation for cryoablation – comparison with bench data, clinical kidney and lung case
Christian Rieder, Michael Schwenke, Torben Pätz, Joachim Georgii, Hanne Ballhausen, Lars Ole Schwen, Sabrina Haase & Tobias Preusser
The accuracy of a numerical simulation of cryoablation ice balls was evaluated in gel phantom data as well as clinical kidney and lung cases.
Materials and methods
To evaluate the accuracy, 64 experimental single-needle cryoablations and 12 multi-needle cryoablations in gel phantoms were re-simulated with the corresponding freeze-thaw-freeze cycles. The simulated temperatures were compared over time with the measurements of thermocouples. For single needles, temperature values were compared at each thermocouple location. For multiple needles, Euclidean distances between simulated and measured isotherms (10 °C, 0 °C, −20 °C, −40 °C) were computed. Furthermore, surface and volume of simulated 0 °C isotherms were compared to cryoablation-induced ice balls in 14 kidney and 13 lung patients. For this purpose, needle positions and relevant anatomical structures defining material parameters (kidney/lung, tumor) were reconstructed from pre-ablation CT images and fused with postablation CT images (from which ice balls were extracted by manual delineation).
The single-needle gel phantom cases showed less than 5 °C prediction error on average. Over all multiple needle experiments in gel, the mean and maximum isotherm distance were less than 2.3 mm and 4.1 mm, respectively. Average Dice coefficients of 0.82/0.63 (kidney/lung) and mean surface distances of 2.59/3.12 mm quantify the prediction performance of the numerical simulation. However, maximum surface distances of 10.57/10.8 mm indicate that locally larger errors have to be expected.
A very good agreement of the numerical simulations for gel experiments was measured and a satisfactory agreement of the numerical simulations with measured ice balls in patient data was shown.
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