Heating Things Up…While Keeping Our Cool!
Heating Things Up…While Keeping Our Cool!
 Heating Things Up…While Keeping Our Cool!
STM Newsletter
-November 2021-
Announcements
STM welcomes our newly elected Council members
STM Business Meeting
STM held a Business Meeting on Oct. 19th from 1:30- 2:30 EST. See the recorded meeting HERE (note, you will be prompted to enter your name and email address) .
Key items include:
1. Upcoming events:  STM will host its annual meeting May 1-4, 2022 virtually. The theme is “Spotlight on Temperature” and the program chair is STM Vice-President Rohan Fernandes.  A call for abstracts will be coming in early winter of 2021 and registration will be discounted for all ACTIVE STM members. 
STM is planning an in-person scientific retreat/ workshop in Fall 2022! 
2. New STM Council members were announced, past member were thanked.
3. STM awardees were highlighted.
4. Development/ revamping of committees was discussed.
5. Updates on membership status were provided.
6. Updates from IJH Editor, Dr. Mark Dewhirst, were provided.
Membership - Support STM
NOW is a critical time to show your support for STM and rebuild your connections!
Membership in The Society for Thermal Medicine is open to anyone interested in the study of thermal medicine.
Membership rights and privileges include:
  • Participating in society elections
  • Committee service
  • Access to restricted “members-only” areas of the STM website
  • Discount on registration fees to the May 2022 STM Virtual Conference
  • Discount on registration fees to the Fall 2022 STM In-Person Mini-Conference and Retreat
  • Free registration to all STM webinars/mini-symposia (includes access to recorded webinars/symposia)
  • A 30% discount on IJH article submission fees 
  • Complementary sponsorship of 2 Scholars-in-Training (offer valid until December 15, 2021)
  • Access to our Monthly Newsletter
  • Career development opportunities such as grant writing/mentorship and participating in diversity/inclusivity/women in science initiatives
Connect with us!
If you have suggestions for how we can better improve STM as we delve together into these new plans, please reach out, and let us know:
Featured clinical article from Dr. Rolf Issels 
International Journal of Hyperthermia updates
Do you like learning more about Thermal Medicine? Remember that STM is the official sponsor for the International Journal of Hyperthermia.

STM members receive a valuable 30% discount on publishing charges.  Now is a great time to work from home and write your manuscripts for submission to IJH!  IJH is on track to receive a record number of submissions this year and its impact factor continues to increase annually (3.914 for 2021).  
IJH is always interested in innovative ideas to increase the breadth of the journal and we strongly hope that the special issues venue will help in the expansion. We are open to additional Industry-Sponsored or Foundation sponsored Special Issues. Please let us know if you have an idea for one!
Featured International Journal of Hyperthermia highlighted articles
Petros X. E. Mouratidis & Gail ter Haar
Published online: 6 October Oct 2021
Views: 159
Sub-ablative heat induces pleiotropic biological effects in cancer cells, activating programmed cell death or survival processes. These processes decide the fate of the heated cell. This study investigates these and assesses whether heat, in combination with HSP90 inhibition, augments cell death and induces a pro-immune phenotype in these cells.
Methods
HCT116 and HT29 cells were subjected to thermal doses (TID) of 60 and 120CEM43 using a PCR thermal cycler. HSP90 was inhibited with NVP-AUY922. Viability was assessed using the MTT assay. Cellular ATP and HSP70 release were assessed using ATP and Enzyme-linked Immunosorbent assays, respectively. Flow cytometry and immunoblotting were used to study the regulation of biomarkers associated with the heat shock response, the cell cycle, and immunogenic and programmed cell death.
Results
Exposure of HCT116 and HT29 cells to TIDs of 60 and 120CEM43 decreased their viability. In addition, treatment with 120CEM43 increased intracellular HSP70 and the percentage of HCT116/HT29 cells in the G2/M cell cycle phase, ATP release and Calreticulin/HSP70/HSP90 exposure in the plasma membrane, while downregulating CD47 compared to sham-exposed cells. When combined with NVP-AUY922, treatment of HCT116/HT29 cells with 120CEM43 resulted in a synergistic decrease of cell viability associated with the induction of apoptosis. Also, the combined treatments increased Calreticulin exposure, CD47 downregulation, and HSP70 release compared to the sham-exposed cells.
Conclusion
Sub-ablative heating can act synergistically with the clinically relevant HSP90 inhibitor NVP-AUY922 to induce a pro-immunogenic form of cell death in colon cancer cells.
Keywords: Thermal dose, HSP90 inhibition, NVP-AUY922, heat shock, proteins, thermal ablation, hyperthermia
Margarethus M. Paulides, Dario B. Rodrigues, Gennaro G. Bellizzi, Kemal Sumser, Sergio Curto, Esra Neufeld, Hazael Montanaro, H. Petra Kok & Hana Dobsicek Trefna
Published online: 28 September 2021
Views: 367
Abstract
Background
The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment planning, optimization and decision making, as well as real-time treatment guidance.
Materials and methods
The same computational methods deployed in HTP are also used for in silico studies. These are of great relevance for the development of new HT devices and treatment approaches. To aid this work, 3 D patient models have been recently developed and made available for the HT community. Unfortunately, there is no consensus regarding tissue properties, simulation settings, and benchmark applicators, which significantly influence the clinical relevance of computational outcomes.
Results and discussion
Herein, we propose a comprehensive set of applicator benchmarks, efficacy and safety optimization algorithms, simulation settings and clinical parameters, to establish benchmarks for method comparison and code verification, to provide guidance, and in view of the 2021 ESHO Grand Challenge (Details on the ESHO grand challenge on HTP will be provided at https://www.esho.info/).
Conclusion
We aim to establish guidelines to promote standardization within the hyperthermia community such that novel approaches can quickly prove their benefit as quickly as possible in clinically relevant simulation scenarios. This paper is primarily focused on radiofrequency and microwave hyperthermia but, since 3 D simulation studies on heating with ultrasound are now a reality, guidance as well as a benchmark for ultrasound-based hyperthermia are also included
Yoo Sang Baek, Anna Kim, Ji Yun Seo, Jiehyun Jeon, Chil Hwan Oh, Jaeyoung Kim
Published online: 7 Oct 2021
Views: 138


Background
Clinical differentiation between pigmented basal cell carcinoma (BCC) and seborrheic keratosis (SK) can sometimes be difficult. Noninvasive diagnostic technologies, such as thermal imaging, can be helpful in these situations. This study explored the use of dynamic thermal imaging (DTI), which records thermal images after the application of external thermal stimuli (heat or cold) for the differential diagnosis of pigmented BCC and SK.
Materials and methods
Twenty-two patients with pigmented BCC and 15 patients with SK participated in this study. Dynamic thermal images of lesions (pigmented BCC or SK) and control sites (contralateral normal skin) were recorded after the heat and cold stimuli. Temperature changes in the region of interest (ROI) are plotted as a thermal response graph. After fitting an exponential equation to each thermal response graph, the rate constants were compared between groups (pigmented BCC versus control, SK versus control).
Results
The thermal response graphs revealed that the average temperature of pigmented BCC showed faster thermal recovery to baseline than the control site. There was a significant difference in the rate constants of the fitted exponential equations between the pigmented BCCs and the control sites (p<.001). However, we did not find a significantly different thermal recovery pattern between SK lesions and control sites.
Conclusions
DTI can be used as a diagnostic tool for distinguishing pigmented BCC from SK by comparing thermal recovery patterns between target lesions (pigmented BCC or SK) and the control site.
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