SenNet to Create 3D Atlas of Aging Tissues, Shed Light on Health, Disease
SenNet to Create 3D Atlas of Aging Tissues, Shed Light on Health, Disease
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Oct. 20, 2021

$125 Million in Grants to Study Cellular Aging to Be Coordinated from Pittsburgh

NIH-funded SenNet to Create 3D Atlas of Aging Tissues, Shedding Light on Nerve Degeneration, Diabetes, Cancer and Normal Tissue Functions


Grants totaling as much as $125 million over five years to 16 institutions across the U.S. will enable scientists to explore the human body at the molecular level, studying how its cells and tissues age and the role cellular aging plays in health and disease. Funded by the National Institutes of Health (NIH) and coordinated by scientists in Pittsburgh, the Cellular Senescence Network (SenNet) will create a navigable, 3D map of the body that offers data and analysis on cellular aging. A team to coordinate and provide the computational infrastructure necessary for the effort, led from Pittsburgh, will be funded at a level of $3.5 million in the first year, with a total of $17.5 million over five years.
SenNet’s Consortium Organization and Data Coordinating Center (CODCC) will be led by Principal Investigators (PIs) Jonathan Silverstein of the University of Pittsburgh, Ziv Bar-Joseph of the Carnegie Mellon University School of Computer Science and Phil Blood of the Pittsburgh Supercomputing Center (PSC), a joint research center of CMU and Pitt.
“I think that the science of senescent cells is tremendously exciting because of their potential impact on a whole variety of diseases,” said Silverstein, Chief Research Informatics Officer, Health Sciences and Institute for Precision Medicine and Professor, Department of Biomedical Informatics, at the Pitt School of Medicine. “By doing the basic science of collecting all of this information and presenting it through SenNet, there is incredible potential to learn more about the role these cells play in disease and develop pharmaceuticals that target them.”
“This opportunity to grow our multi-institutional collaboration we established in HuBMAP is as exciting as the science of the SenNet Consortium itself,” he added. The Human BioMolecular Atlas Program (HuBMAP) is an NIH-funded, multi-institution project currently mapping the human body’s normal healthy tissues in a similar way to SenNet to form the basis of comparisons. Bar-Joseph, Blood, and Silverstein collaborate closely as PIs in HuBMAP.
As cells and tissues in human bodies age, they lose their ability to grow and repair themselves. This process, called cellular senescence, is central to aging and a number of human diseases, among them Alzheimer's disease, amyotrophic lateral sclerosis, type 2 diabetes, and some cancers. It’s also front and center in a number of healthy life processes at all ages. But scientists don’t know nearly as much as they’d like about how cells age, the effects of senescence on neighboring tissues and above all how the process leads to disease.
SenNet’s core mission will be to dive deep into the process of cellular senescence, decoding how it happens both biochemically and at the level of microscopic anatomy. The goal will be to create a kind of “Google Maps” of the aging tissues of the body, which can be navigated by scientists studying any number of processes in health and disease. Just as Google Maps provides detailed information about every locale it stores, SenNet will provide data and analysis about the process of senescence for cells, tissues and organs, down to the molecular scale. This “metadata” will include information on the provenance of each bit of data, establishing a rigorous chain of evidence that validates the accuracy of the information.
SenNet aims to unite cellular senescence researchers by developing common terms and classifications for senescent cells. SenNet will provide data and resources to the public that would otherwise be difficult to achieve through individual efforts, accelerating the ability of biomedical researchers to develop therapeutics that target cellular senescence and improve human health.
The initial SenNet awards amount to $125 million over five years, pending available funding. Under the guidance of a working group led by the Office of the Director, the National Institute on Aging, and the National Cancer Institute, the SenNet program plans to expand to include mouse models and additional technology development through future awards. The estimated overall budget is $191 million, again pending available funds.
The CODCC, in addition to managing the SenNet Consortium, will serve the crucial role of providing computing software and hardware that will knit together SenNet’s eight Tissue Mapping Centers and seven Technology Development and Application Projects. Focusing on data analysis and integration, the Pittsburgh-led center will set standards for data accuracy and provenance, provide reliable and expansive data storage, and disseminate data and analytical tools to help scientists make sense of what is expected to be a tsunami of information. Together, the SenNet projects will create and provide a publicly accessible and searchable 3D Atlas of Cellular Senescence.
“Analyzing and integrating the vast amounts of data collected by all the teams participating in this project would be a major challenge that the CODCC will address,” said Bar-Joseph, FORE Systems Professor of Computer Science at the CMU School of Computer Science’s Machine Learning Department and the Computational Biology Department.
“We’re excited to extend our flexible hybrid cloud data infrastructure to enable the large-scale machine learning, data analysis, and integration that will be required to achieve the goals of SenNet,” said Blood, Scientific Director at PSC.
SenNet is a trans-NIH program funded by the NIH Common Fund and overseen in collaboration with the National Institute on Aging and National Cancer Institute. The Pittsburgh group’s NIH award number is U24CA268108.
About the University of Pittsburgh Schools of the Health Sciences: The University of Pittsburgh Schools of the Health Sciences include the schools of Medicine, Nursing, Dental Medicine, Pharmacy, Health and Rehabilitation Sciences and the Graduate School of Public Health. The schools serve as the academic partner to the UPMC (University of Pittsburgh Medical Center). Together, their combined mission is to train tomorrow’s health care specialists and biomedical scientists, engage in groundbreaking research that will advance understanding of the causes and treatments of disease and participate in the delivery of outstanding patient care. Since 1998, Pitt and its affiliated university faculty have ranked among the top 10 educational institutions in grant support from the National Institutes of Health. For additional information about the Schools of the Health Sciences, please visit www.health.pitt.edu. 
About UPMC: A $20 billion health care provider and insurer, Pittsburgh-based UPMC is inventing new models of patient-centered, cost-effective, accountable care. The largest nongovernmental employer in Pennsylvania, UPMC integrates 89,000 employees, 40 hospitals, 700 doctors’ offices and outpatient sites, and a nearly 3.6 million-member Insurance Services Division, the largest medical insurer in western Pennsylvania. In the most recent fiscal year, UPMC contributed $1.2 billion in benefits to its communities, including more care to the region’s most vulnerable citizens than any other health care institution, and paid $587 million in federal, state and local taxes. Working in close collaboration with the University of Pittsburgh Schools of the Health Sciences, UPMC shares its clinical, managerial and technological skills worldwide through its innovation and commercialization arm, UPMC Enterprises, and through UPMC International. U.S. News & World Report consistently ranks UPMC Presbyterian Shadyside on its annual Honor Roll of America’s Best Hospitals and ranks UPMC Children’s Hospital of Pittsburgh on its Honor Roll of America’s Best Children’s Hospitals. For more information, go to UPMC.com.
About CMU School of Computer Science: Carnegie Mellon’s School of Computer Science is widely recognized as one of the first and best computer science programs in the world. Our programs train the next generation of innovators to solve real-world problems and improve the way people live and work.
About PSC: The Pittsburgh Supercomputing Center (PSC) is a joint computational research center with Carnegie Mellon University and the University of Pittsburgh. PSC provides university, government and industrial researchers with access to several of the most powerful systems for high-performance computing, communications and data storage available to scientists and engineers nationwide for unclassified research. PSC advances the state of the art in high-performance computing, communications and data analytics and offers a flexible environment for solving the largest and most challenging problems in research. See www.PSC.edu.
CONTACT:
Ken Chiacchia
Pittsburgh Supercomputing Center
chiacchi@psc.edu
412.268.5869
Asher Jones
University of Pittsburgh Schools of the Health Sciences
jonesAG@upmc.edu
412.639.6222
Aaron Aupperlee
CMU School of Computer Science
aaupperlee@cmu.edu
412.268.9068
300 S. Craig Street | Pittsburgh, PA 15213 US
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