Roger V Short Medal Lecture:
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A Decade of Discovery: Ovarian Aging from Mechanisms to Clinical Translation |
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Join us on January 29, 2025 from 12:00 - 1:00 pm CST (06:00 - 07:00 pm UTC) as Dr. Francesca E. Duncan presents a decade of groundbreaking research from her lab on the ovarian microenvironment.
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Speaker: Francesca E. Duncan, PhD, Associate Professor,
Obstetrics and Gynecology
Recipient: Roger Short Medal
Thomas J. Watkins Memorial Professor in Reproductive Science
Co-Director, Center for Reproductive Science
Feinberg School of Medicine, Northwes tern University, Chicago, IL
Talk Title: A Decade of Discovery: Ovarian Aging from Mechanisms to Clinical Translation
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Description:
In the Roger V Short Medal Lecture, Dr. Francesca E. Duncan will present a decade of groundbreaking research from her lab on the ovarian microenvironment. The Duncan lab discovered that the ovary becomes inflammatory, fibrotic, and stiff with advanced reproductive age, and this has significant biological consequences for ovarian physiology and pathology. These findings shifted the paradigm in the field, putting forth the concept that egg quality is not only intrinsic to the gamete itself but also dependent on the microenvironment in which it grows and develops. The research team is now developing innovative approaches to modulate, measure, and model the ovarian microenvironment by leveraging advanced omics technologies, biomechanical methods, ultrasound-based shear wave elastography, and tissue engineering. Dr. Duncan will discuss how she is moving her work from bench-to-bedside to develop tissue stiffness as a biomarker of ovarian aging and fibrosis as a therapeutic target to extend reproductive longevity and promote healthy aging.
This prestigious international award is a joint initiative of the Society for Reproductive Biology (SRB, Australia and New Zealand), the Society for Reproduction and Fertility (SRF, UK) and the Society for the Study of Reproduction (SSR, North America) to support outstanding young researchers in the reproductive sciences.
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Learning Objectives:
- Define the impact of female reproductive aging from fertility to general health outcomes.
- Identify age-related changes in the ovarian microenvironment including changes in inflammatory profiles, extracellular matrix composition, and biomechanical properties.
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Examine the biological consequences of the aging ovarian microenvironment from follicle development and egg quality to ovulation and ovarian cancer.
- Explore self-assembling organoids as an innovative new model for broadening our understanding of the ovarian somatic compartment.
- Consider the clinical potential of low dose anti-fibrotics and shear wave elastography as strategies to modulate and measure the aging ovarian microenvironment, respectively.
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About SSR: The Society for the Study of Reproduction (SSR) was founded in 1967 to promote the study of reproduction by fostering interdisciplinary communication among scientists, holding conferences, and publishing meritorious studies. Today, our members come from 50 countries around the world. |
Society for the Study of Reproduction |401 Edgewater Place, Suite 600, Wakefield, MA 01880 |
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