By Basic Sciences department

Biochemistry

• Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. eLife.
  Jinsai Shang* (Guangzhou Medical University), Douglas Kojetin*.
  
  
• Cryo-EM structure of the CBC-ALYREF complex. eLife.
  Bradley Clarke*, Alexia Angelos, Menghan Mei, Pate Hill, Yihu Xie, Yi Ren*.
  
  Basic Sciences: New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
  
  
• Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine (preprint). bioRxiv.
  Abdulkadir Elmas* (Icahn School of Medicine at Mount Sinai), Hillary Layden, Jacob Ellis, Luke Bartlett, Scott Hiebert.
  
  
• The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. British Journal of Pharmacology.
  Tom Teichmann* (Goethe University Frankfurt), Paola Munoz-Tello, Douglas Kojetin.
  

Cell and Developmental Biology

• Super-resolution multi-contrast unbiased eye atlases with deep probabilistic refinement. Journal of Medical Imaging.
  Ho Hin Lee*, Adam Saunders*, Michael Kim, Lucas Remedios, Yucheng Tang, Qi Yang, Xin Yu, Shunxing Bao, Chloe Cho, Louise Mawn, Tonia Rex, Kevin Schey, Jeffrey Spraggins, Yuankai Huo, Bennett Landman.
  
  
• Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse. Frontiers in Cellular Neuroscience.
  Katrina Hofstetter*, Paula Haas, Jonathon Kuntz, Sabine Fuhrmann*.
  
  
• In Situ molecular profiles of glomerular cells by integrated imaging mass spectrometry and multiplexed immunofluorescence microscopy. Kidney International.
  Allison Esselman*, Lukasz Migas, Katerina Djambazova, Madeline Colley, Ellie Pingry, Nathan Heath Patterson, Melissa Farrow, Haichun Yang, Agnes Fogo, Mark de Caestecker, Raf Van de Plas*, Jeffrey Spraggins*.
  
  
• Organization of a cytoskeletal superstructure in the apical domain of intestinal tuft cells. Journal of Cell Biology.
  Jennifer Silverman*, Evan Krystofiak, Leah Caplan, Ken Lau, Matthew Tyska*.
  
  VUMC News: What’s all the tuft about?
  

Molecular Physiology and Biophysics

• G_12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis. Nature Communications.
  Srinivas Pittala* (National Institute of Diabetes and Digestive and Kidney Diseases), Owen McGuinness.
  
  
• Air pollutants as modulators of mitochondrial quality control in cardiovascular disease. Physiological Reports.
  Kit Neikirk*, Chanel Harris, Han Le, Ashton Oliver, Bryanna Shao, Heather Beasley, Sydney Jamison, Jeanne Ishimwe, Annet Kirabo, Antentor Hinton Jr.*
  
  
• Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice. Diabetes.
  Michael Schleh*, Magdalene Ameka, Alec Rodriguez, Alyssa Hasty*.
  
  
• AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation. PNAS.
  Jessica Biddinger*, Payam Fathi, Serena Sweet, Julio Ayala, Richard Simerly*.
  
  Basic Sciences: Vanderbilt researchers find evidence that the hunger hormone leptin can direct neural development in a leptin receptor–independent manner
  

Pharmacology

• Functional specificity of liquid-liquid phase separation at the synapse. Nature Communications.
  Natalie Guzikowski*, Ege Kavalali*.
  
  
• The cannabinoid CB₂ receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro. Journal of Receptors and Signal Transduction.
  Aidong Qi*, Xueqing Han, Marc Quitalig, Jessica Wu, Plamen Christov, KyuOk Jeon, Somnath Jana, Kwangho Kim, Darren Engers, Craig Lindsley, Alice Rodriguez, Colleen Niswender*.
  
  
• Psychedelics and Entactogens: Call for Papers. Journal of Medicinal Chemistry.
  Craig Lindsley*.
  

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