Pediatric Epilepsy Advanced Technologies Clinic (PEATC)
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Dravet Syndrome and Epilepsy
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Dravet syndrome, previously known as Severe Myoclonic Epilepsy of Infancy (SMEI), is a rare genetic epilepsy syndrome characterized by:
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multiple medication-resistant seizure types
- developmental stagnation or regression
- higher risk for status epilepticus and SUDEP
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Improving quality of life
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There is currently no cure for Dravet syndrome but treatment options are available which focus on improving quality of life.
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- Anti-seizure medications
- appropriately chosen medications can improve seizure burden
- medications recently approved specifically for treatment of Dravet syndrome
- Advanced interventions
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Vagus Nerve Stimulation (VNS)
- Deep Brain Stimulation (DBS)
- Ketogenic diet
- Environmental measures
- heat avoidance
- plan for illnesses and vacations
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Multi-step seizure rescue plan
- awareness that seizures may not stop with first rescue medication
- incorporate a STARS (Special Needs Tracking & Awareness Response System) plan for EMS
- Therapies
- physical, occupational, speech and communication
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It is crucial to work closely with healthcare professionals specializing in Dravet syndrome to develop individualized care plans to maximize quality of life.
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Although there is currently no cure for Dravet syndrome, research for disease modifying treatments offer families hope. Since 2018, three new medications have received FDA approval for treatment of Dravet syndrome.
In addition, over 80% of those with Dravet syndrome have an SCN1a pathogenic variant. This provides an attractive target for biomedical research and therapies which have the potential to address the root cause:
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- ASO (anti-sense nucleotide) based treatments show encouraging results in phase 1/2 trials
- gene-based therapy trials are starting recruitment
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Meet the provider - Oleg Lobanov, MD, PhD
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Dr. Oleg Lobanov is an Assistant Professor of Neurology in the Section of Pediatric Epilepsy at Washington University School of Medicine in St. Louis, MO. He is board certified in Child Neurology and Epilepsy.
Dr. Lobanov's clinical practice focuses on difficult-to-treat epilepsies, surgical epilepsy, and intracranial monitoring (sEEG and subdural grids).
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Born in Ivanovo, Russia, Dr. Lobanov attended University of Texas at Arlington for undergraduate studies where he graduated Summa Cum Laude with a BS in Biology and Chemistry.
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| He completed a combined MD/PhD program at Wake Forest School of Medicine. His graduate work was directed by Dr. Robert Coghill and concentrated on mapping mechanisms supporting expectations and attention utilizing functional MRI.
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Dr. Lobanov then moved to St. Louis where he completed his Child Neurology Residency and Pediatric Epilepsy Fellowship at Washington University School of Medicine. He joined the faculty in 2020 as a pediatric neurologist specializing in epilepsy.
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As a clinician, Dr. Lobanov was awarded the Castle Connolly Rising Star Award three years in a row as well as the St Louis Children's Hospital Triple Crown Award.
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As a teacher, he was recognized by the 2022 Neurology Clerkship Teaching Award Honor Roll. More recently he received the Arthur L Prensky award for Outstanding Teaching by a Pediatric Neurology Attending as selected by the pediatric and adult neurology residents.
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In his role as a Clinician, Dr. Lobanov sees patients in both outpatient and inpatients settings. His inpatient practice at St. Louis Children's Hospital includes the:
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- Neuroscience inpatient unit
- Neurology inpatient consult service
- Epilepsy Monitoring Unit (EMU)
- ICU EEG service
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| In his role as a Teacher, he is involved in the education of those with a special interest in neurology:
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Medical students
- Neurology residents
- Epilepsy fellows
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With Dr. Lobanov's unique background, he is able to draw on his scientific knowledge to interpret complex relationships between enormous amounts of data collected as part of an epilepsy surgical evaluation.
He also employs his excellence in teaching to guide patients and families through the diagnosis and treatment of difficult-to-treat epilepsy and epilepsy surgery.
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| When not at work, Dr. Lobanov enjoys spending time with his family and chocolate lab, Roy.
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Lobanov O.V., Shimony J.S., Kenley J., Kaplan S., Alexopoulos D., Roland J.L., Smyth M.D., Smyser C.D. Alterations in resting-state functional connectivity in pediatric patients with tuberous sclerosis complex. Epilepsia Open. 2021; 579-587.
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Zeidan F., Lobanov O.V., Kraft R.A., Coghill R.C. Brain Mechanisms Supporting Violated Expectations of Pain. PAIN. 2015; 156:9.
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Lobanov O.V., Zeidan F., McHaffie J.G., Kraft R.A., Coghill R.C. From cue to meaning: Brain mechanisms supporting the construction of expectations of pain. PAIN. 2014; 155:1.
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Emerson N.M., Zeidan F., Lobanov O.V., Hadsel M.S., Martucci K.T., Quevedo A.S., Starr C.J., Nahman-Averbuch H., Weisman-Fogel I., Granovsky Y., Yarnitsky D., Coghill R.C. Pain Sensitivity is Inversely Related to Regional Grey Matter Density in the Brain. PAIN. 2014; 155:3.
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Lobanov O.V., Quevedo A.S., Hadsel M.S., Kraft R.A., Coghill R.C. Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli. PAIN. 2013; 154:9.
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The Pediatric Epilepsy Advanced Technologies Clinic (PEATC) is a specialty concierge clinic at the Washington University NAEC-accredited Level 4 Pediatric Epilepsy Center at St. Louis Children’s Hospital.
PEATC offers the highest level of care for children and young adults with treatment-resistant epilepsy providing support and resources to improve quality of life and seizure management through reduction or elimination of seizures.
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Pediatric Epilepsy Advanced Technologies Clinic
https://pediatricneurology.wustl.edu/items/peatc/
peatc@wustl.edu | 314-454-6120
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Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130
washu.edu
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Washington University in St. Louis
One Brookings Drive
St. Louis, MO 63130
washu.edu
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