EGFR dimerization and allosteric control, branched glucan assembly, the blood-CSF barrier, MECP2-related disorders, and more

The Reading List: The latest biomedical research from Vanderbilt’s SOMBS

The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.

Transcriptomic and proteomic signatures following AS03-adjuvanted Influenza A/H7N9 vaccine. Frontiers in Immunology.
C. Buddy Creech*, Leigh Howard, Kevin Schey, Kristie Lindsey Rose, Sandra Yoder, Kathryn Edwards, Johannes Goll*.
From Sequence to Structure: An Active Learning Approach with PyMOL and AlphaFold. CourseSource.
Alaina Willet*, Madhvi Venkatesh.
Asymmetric dimerization and allosteric control in the epidermal growth factor receptor. Philosophical Transactions of the Royal Society B.
Yongjian Huang*, Timothy Eisen, Arathi Nair, Serena Muratcioglu, John Kuriyan*.
Protein-enhanced small molecule disruptors of ordered membrane domains. Proceedings of the National Academy of Sciences.
Katherine Stefanski*, Geoffrey Li, Nilabh Saksena, Yelyzaveta Zuy, Alexander Fisch, Thomas Hasaka, Joshua Bauer, Charles Sanders*.

Supported by the Cell Imaging Shared Resource and the High-Throughput Screening Facility.

School of Medicine Basic Sciences: Researchers create tool to explore the formation and function of cell membrane structures called lipid rafts

Correlative MIMS-EM imaging reveals metabolic turnover from organelle to organismal scales in C. elegans during dietary restriction (preprint). bioRxiv.
Alessandra Norris*, Christopher Acree, Li Peng, Rafael Arrojo e Drigo*, Kristopher Burkewitz*.

Supported by the Cell Imaging Shared Resource.
A bipartite glucan synthase-remodeler module organizes branched glucan assembly in the fungal cell wall. Nature Communications.
Alaina Willet*, Anand Jacob* (Michigan State University), Lesley Turner, Kathleen Gould*.

Supported by the Cell Imaging Shared Resource.

The role of individual residues in arrestin-3 finger loop in its binding to β2-adrenergic receptor. Biochemical Pharmacology.
Chen Zheng*, Steven Lee, Eugenia Gurevich, Vsevolod Gurevich*.
Exploration of the therapeutic potential of the HRH3 histamine receptor in MECP2-related disorders. Neuropharmacolgy.
Kelly Weiss*, Sheryl Vermudez, Geanne Freitas, Shalini Dogra, Mac Meadows, Colleen Niswender*.

Supported by the Mouse Neurobehavioral Lab Core and the Warren Center for Neuroscience Drug Discovery.

First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.

Proofig AI is your go-to platform for catching image issues like duplications, manipulations, plagiarism, and AI-generated problems. This resource is provided at no cost to primary SOMBS faculty and is part of our commitment to supporting research excellence and maintaining the highest standards of scientific integrity. Faculty can access Proofig by visiting its homepage or their OneVU dashboard.

Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter. Please send the paper’s URL.

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Vanderbilt University School of Medicine Basic Sciences

MRB III U-1200 465 21st Avenue South | Nashville, TN 37240 US

Phone: (615) 322-0907 | basicsciences@vanderbilt.edu

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