The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
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Structure-based discovery and definition of RiPP recognition elements. mSystems.
Miriam Bregman* (University of Illinois at Urbana-Champaign), Andrew Rice, Shravan Dommaraju, Douglas Mitchell*. -
A periplasmic zinc capture protein enhances the resistance of Neisseria gonorrhoeae to nutritional immunity. Proceedings of the National Academy of Sciences.
Ian Liyayi* (University of Virginia), Yasiru Perera, Indu Bhatia, Walter Chazin. -
Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function (preprint). bioRxiv.
Katherine Stefanski*, Hui Huang, Nilabh Saksena, Alexander Fisch, Thomas Hasaka, Joshua Bauer, Charles Sanders*.
Supported by the High-Throughput Screening Facility. -
Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective. Journal of Medicinal Chemistry.
David Twigg* (Astex Pharmaceuticals), Stephen Fesik.
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Department of Cell and Developmental Biology |
- Non-Muscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling. Circulation Research.
James Hayes*, Dharmendra Choudhary, Dylan Ritter, Abigail Neininger-Castro, Alaina Willet, Leah Caplan, Yu Wang, Xiao Liu, Nilay Taneja, Zachary Sanchez, Kyra Smart, David Armstrong, Cynthia Reinhart-King, Qi Liu, Matthew Tyska, W. David Merryman, Quinn Wells, Ela Knapik, Dylan Burnette*.
Supported by the Cell Imaging Shared Resource. -
CLASP1/2 regulate immune synapse maturation in natural killer cells. Journal of Leukocyte Biology.
Alejandro Pariani* (Universidad Nacional de Rosario), James Goldenring, Irina Kaverina. -
InsP3R signaling mediates mitochondrial stress-induced longevity through actomyosin-dependent mitochondrial dynamics (preprint). bioRxiv.
Gaomin Feng*, Elizabeth Ruark*, Alexandra Mulligan, Eric Donahue, Anthony Hoang, Brianne Jacquet-Cribe, Li Peng, Kristopher Burkewitz*.
Supported by the Cell Imaging Shared Resource. -
Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex (preprint). bioRxiv.
Murugesh Padmanarayana* (Stanford University School of Medicine), Ethan Lee. - Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression (preprint). bioRxiv.
Lei Chen*, Ankita Roy, Chin Chiang*.
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Department of Molecular Physiology and Biophysics |
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Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation. Nature Communications.
Qingyu Tang*, Paola Bisignano, Hassane Mchaourab*.
Supported by the CSB Cryo-EM Facility. -
Risk of Coronary Artery Disease Associated With Transitions in Metabolic Health in a Clinical Cohort of 69 272. Journal of the American Heart Association.
Megan Shuey*, Rebecca Levinson, Megan Vogel, Eric Farber-Eger, Shi Huang, Frank Harrel Jr., Alyssa Hasty, Jonathan Brown, Heidi Silver, John Koethe, Joshua Beckman, Nancy Brown, Kevin Niswender, Nancy Cox, Quinn Wells*.
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Department of Pharmacology |
- Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. JAMA Dermatology.
Michelle Martin-Pozo*, Elizabeth Williams*, Kemberlee Bonnet, David Schlundt, Elizabeth Phillips*.
VUMC News: New study reveals long-term impacts on Stevens-Johnson syndrome survivors -
Trypsin Activates Human Platelets via Proteolytic Cleavage of Protease-activated Receptor 4 (PAR4). Thrombosis and Haemostasis.
Emma Webb*, Kendal Seymour, Heidi Hamm*.
Supported by the High-Throughput Screening Facility. - The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation. Proceedings of the National Academy of Sciences.
Xue Yang* (Stanford University School of Medicine), Feng He* (Stanford University School of Medicine), Krassimira Garbett, Duy Lan Huong Bui, Richard Sando. - Structural Biology Enabling Drug Discovery. Journal of Medicinal Chemistry.
David Heppner* (University at Buffalo), Craig Lindsley. -
Novelty influences dopamine responses to conditioned and unconditioned aversive stimuli over extended temporal windows.
eNeuro.
Munir Gunes Kutlu* (Temple University Lewis Katz School of Medicine), Stephanie Cajigas Gabriel, Jennifer Tat, Jennifer Zachry, Erin Calipari*. -
Chapter Eight: Parameterizing non-canonical amino acids for cyclic peptide simulations (book chapter). Methods in Enzymology, Volume 723: Cyclic Peptides.
N. Kithmini Wijesiri*, Benjamin Brown*. -
Characterization of Perineuronal Nets in the Paraventricular Nucleus of the Hypothalamus and their Alteration in Neurogenic Hypertension. Cellular and Molecular Neurobiology.
Ismary Blanco*, Sichu Chen, Erin Yeo, Samantha Reasonover, Monica Santisteban*.
Supported by the Vanderbilt Neurochemistry Core. -
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution. Neuron.
Samantha Schaeffer* (Weill Cornell Medicine), Monica Santisteban.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
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