MP faculty publications: March 2021

1. Correction: Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells

   Sowd GA, Aiken C
   PLoS Pathog. 2021 Mar 2;17(3):e1009389

2. HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription

   Rankovic S, Deshpande A, Harel S, Aiken C, Rousso I
   J Virol. 2021 Mar 10:JVI.00166-21

3. Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus

   Lu J, Francis JD, Guevara MA, Moore RE, Chambers SA, Doster RS, Eastman AJ, Rogers LM, Noble KN, Manning SD, Damo SM, Aronoff DM, Townsend SD, Gaddy JA
   Chembiochem. 2021 Mar 23

4. Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease

   Crooke PS 3rd, Tossberg JT, Porter KP, Aune TM
   J Immunol. 2021 Mar 29:ji2001428

5. Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy

   Lahrouchi N, Postma AV, Salazar CM, De Laughter DM, Tjong F, Piherová L, Bowling FZ, Zimmerman D, Lodder EM, Ta-Shma A, Perles Z, Beekman L, Ilgun A, Gunst Q, Hababa M, Škorić-Milosavljević D, Stránecký V, Tomek V, de Knijff P, de Leeuw R, Robinson JY, Burn SC, Mustafa H, Ambrose M, Moss T, Jacober J, Niyazov DM, Wolf B, Kim KH, Cherny S, Rousounides A, Aristidou-Kallika A, Tanteles G, Ange-Line B, Denommé-Pichon AS, Francannet C, Ortiz D, Haak MC, Ten Harkel AD, Manten GT, Dutman AC, Bouman K, Magliozzi M, Radio FC, Santen GW, Herkert JC, Brown HA, Elpeleg O, van den Hoff MJ, Mulder B, Airola MV, Kmoch S, Barnett JV, Clur SA, Frohman MA, Bezzina CR
   J Clin Invest. 2021 Mar 1;131(5):142148

6. Standardization of Methods for Sampling the Distal Airspace in Mechanically Ventilated Patients using Heat Moisture Exchange Filter Fluid

   Bastarache JA, McNeil JB, Plosa E, Sucre JS, Kerchberger VE, Habegger LE, Weddle EA, Sullivan BF, Meegan JE, Wickersham NE, Shaver CM, Ware LB
   Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3

7. TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection

   Owen AM, Fults JB, Patil NK, Hernandez A, Bohannon JK
   Front Immunol. 2021 Feb 18;11:622614

8. AMPK Metabolism in the B Lineage Modulates Humoral Responses

   Brookens SK, Boothby MR
   Immunometabolism. 2021;3(2):e210011

9. The impacts of cytoplasmic incompatibility factor (cifA and cifB) genetic variation on phenotypes

   Shropshire JD, Rosenberg R, Bordenstein SR
   Genetics. 2021 Mar 3;217(1):1-13

10. Infectious Osteomyelitis: Marrying Bone Biology and Microbiology to Shed New Light on a Persistent Clinical Challenge

    Veis DJ, Cassat JE
    J Bone Miner Res. 2021 Mar 19

11. Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis

    Gimza BD, Cassat JE
    Front Immunol. 2021 Feb 12;12:638085

12. Murine Models for Staphylococcal Infection

    Klopfenstein N, Cassat JE, Monteith A, Miller A, Drury S, Skaar E, Serezani CH
    Curr Protoc. 2021 Mar;1(3):e52

13. Changes in FXR1 expression after Chemotherapy for Rhabdomyosarcoma

    Xu MC, Ghani MO, Apple A, Chen H, Whiteside M, Borinstein SC, Correa H, Lovvorn HN
    J Pediatr Surg. 2021 Feb 24:S0022-3468(21)00172-X

14. Prediagnostic antibody responses to Fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large United States consortium

    Lo CH, Blot WJ, Teras LR, Visvanathan K, Le Marchand L, Haiman CA, Chen Y, Sesso HD, Wassertheil-Smoller S, Tinker LF, Peek RM, Potter JD, Cover TL, Zeleniuch-Jacquotte A, Berndt SI, Waterboer T, Epplein M, Butt J, Song M
    Cancer Epidemiol Biomarkers Prev. 2021 Mar 18:cebp.1471.2020

15. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

    Schoeder CT, Schmitz S, Adolf-Bryfogle J, Sevy AM, Finn JA, Sauer MF, Bozhanova NG, Mueller BK, Sangha AK, Bonet J, Sheehan JH, Kuenze G, Marlow B, Smith ST, Woods H, Bender BJ, Martina CE, Del Alamo D, Kodali P, Gulsevin A, Schief WR, Correia BE, Crowe JE Jr, Meiler J, Moretti R
    Biochemistry. 2021 Mar 23;60(11):825-846

16. Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

    Suryadevara N, Shrihari S, Gilchuk P, VanBlargan LA, Binshtein E, Zost SJ, Nargi RS, Sutton RE, Winkler ES, Chen EC, Fouch ME, Davidson E, Doranz BJ, Chen RE, Shi PY, Carnahan RH, Thackray LB, Diamond MS, Crowe JE Jr
    Cell. 2021 Mar 16:S0092-8674(21)00357-3

17. Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition

    Chapman NS, Zhao H, Kose N, Westover JB, Kalveram B, Bombardi R, Rodriguez J, Sutton R, Genualdi J, LaBeaud AD, Mutuku FM, Pittman PR, Freiberg AN, Gowen BB, Fremont DH, Crowe JE Jr
    Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2025642118

18. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

    Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O'Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS
    Nat Med. 2021 Mar 4

19. Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults

    Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR Jr, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW; Passive Immunity Trial for Our Nation (PassITON) Investigators
    rials. 2021 Mar 20;22(1):221

20. B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies

    Townsley SM, Donofrio GC, Jian N, Leggat DJ, Dussupt V, Mendez-Rivera L, Eller LA, Cofer L, Choe M, Ehrenberg PK, Geretz A, Gift S, Grande R, Lee A, Peterson C, Piechowiak MB, Slike BM, Tran U, Joyce MG, Georgiev IS, Rolland M, Thomas R, Tovanabutra S, Doria-Rose NA, Polonis VR, Mascola JR, McDermott AB, Michael NL, Robb ML, Krebs SJ
    Cell Host Microbe. 2021 Feb 26:S1931-3128(21)00046-9

21. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice

    Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA
    Front Immunol. 2021 Feb 24;12:630204

22. Collagen IV α345 dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture's and Alport diseases

    Pokidysheva EN, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, Cui ZW, Delpire E, Fervenza F, Fidler AL, Fogo AB, Gaspert A, Grohmann M, Gross O, Haddad G, Harris RC, Kashtan C, Kitching AR, Lorenzen JM, McAdoo S, Pusey CD, Segelmark M, Simmons A, Voziyan PA, Wagner T, Wüthrich RP, Zhao MH, Boudko SP, Kistler AD, Hudson BG
    J Biol Chem. 2021 Mar 24:100590

23. Collagen IV α345 dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer

    Boudko SP, Bauer R, Chetyrkin SV, Ivanov S, Smith J, Voziyan PA, Hudson BG
    J Biol Chem. 2021 Mar 25:100591

24. Collagen IV α345 dysfunction in glomerular basement membrane diseases. III. A functional framework for α345 hexamer assembly

    Pedchenko V, Boudko SP, Barber M, Mikhailova T, Saus J, Harmange JC, Hudson BG
    J Biol Chem. 2021 Mar 25:100592

25. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8 + T cells during the primary immune response

    Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH
    Immunity. 2021 Mar 6:S1074-7613(21)00084-4

26. Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis

    Tao H, Yancey PG, Blakemore JL, Zhang Y, Ding L, Jerome WG, Brown JD, Vickers KC, Linton MF
    J Clin Invest. 2021 Mar 4:94229.

27. Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells

    Wanjalla CN, McDonnell WJ, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Guo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR
    Cell Rep Med. 2021 Feb 16;2(2):100205

28. A burned-out CD8+ T-cell subset expands in the tumor microenvironment and curbs cancer immunotherapy

    Sanmamed MF, Nie X, Desai SS, Villaroel-Espindola F, Badri T, Zhao D, Kim AW, Ji L, Zhang T, Quinlan E, Cheng X, Han X, Vesely MD, Nassar AF, Sun J, Zhang Y, Kim TK, Wang J, Melero I, Herbst RS, Schalper KA, Chen L
    Cancer Discov. 2021 Mar 3:candisc.0962.2020

29. Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts

    Lang KS, Merrikh H
    Cell Rep. 2021 Mar 2;34(9):108797

30. Helicobacter pylori antimicrobial resistance and gene variants in high and low gastric cancer risk populations

    Mannion A, Dzink-Fox J, Shen Z, Piazuelo MB, Wilson KT, Correa P, Peek RM Jr, Camargo MC, Fox JG
    J Clin Microbiol. 2021 Mar 10:JCM.03203-20

31. Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy

    Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E
    Cancer Res. 2021 Mar 22:canres.2870.2020

32. Obesity, Immunity, and Cancer

    Rathmell JC
    N Engl J Med. 2021 Mar 25;384(12):1160-1162

33. SOCS-1 inhibition of type I interferon restrains Staphylococcus aureus skin host defense

    Klopfenstein N, Brandt SL, Castellanos S, Gunzer M, Blackman A, Serezani CH
    PLoS Pathog. 2021 Mar 10;17(3):e1009387

34. Impact of temperature-dependent phage expression on Pseudomonas aeruginosa biofilm formation

    Bisht K, Moore JL, Caprioli RM, Skaar EP, Wakeman CA
    NPJ Biofilms Microbiomes. 2021 Mar 16;7(1):22

35. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

    Patel MR, Weaver AM
    Cell Rep. 2021 Mar 9;34(10):108829