Dear ARI Community,
Hopefully, you’ve had a relaxing and restorative summer so far. In this ARI Special Update, we wanted to invite you to join us to celebrate Dr. Steve Deeks’ receipt of the Lifetime Achievement in Mentoring Award this coming Friday and also highlight the practice-changing results of Dr. Annie Luetkemeyer (UCSF/SFGH) and Connie Celum’s (University of Washington) DoxyPEP study.
Please see more details below!
Diane Havlir
Director, AIDS Research Institute
|
Please join us for an award celebration and reception honoring
Dr. Deeks and his outstanding contributions to faculty mentorship at UCSF.
|
2022 Lifetime Achievement in Mentoring Award
Steven G. Deeks, MD
|
Award Celebration and Reception
Friday August 12, 2022
2:00 – 4:00PM
Carr Auditorium at ZSFG
Reception to follow in Building 100 courtyard
Zoom link will also be available to participate
|
Steven G. Deeks, MD, is a Professor of Medicine and a faculty member in the Division of HIV, Infectious Diseases and Global Medicine at Zuckerberg San Francisco General. He is an internationally recognized expert on the impact of HIV and other viral infections on inflammation, immune function and health. Dr. Deeks has been the recipient of several NIH grants, and is one of the principal investigators of DARE (the Delaney AIDS Research Enterprise), an NIH-funded international collaboratory aimed at developing therapeutic interventions to cure HIV infection. He is also the current principal investigator of amfAR Institute for HIV Cure Research. Dr. Deeks was elected to the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP), and serves on the scientific advisory board for Science Translational Medicine. By leveraging his HIV and now COVID cohorts, Dr. Deeks has contributed to the training of dozens of students, residents, fellows, and junior faculty and has co-mentored 14 K award-recipients. He received two consecutive K24 mentoring grants and currently co-directs an T32 HIV/AIDS training program. He co-chairs an annual three-day mentoring retreat in South Africa that trains early-stage investigators from around the world who are hoping to start a research program aimed at curing or preventing HIV. In addition to his research and mentoring activities, Dr. Deeks maintains a primary care clinic for people living with HIV.
|
|
|
| The DoxyPEP study, led by UCSF’s Annie Luetkemeyer and University of Washington’s Connie Celum, found that taking 200mg of doxycycline within 72 hours of condomless sex reduced the risk of gonorrhea, chlamydia, and syphilis by 65% compared to not taking doxycycline among men who have sex with men and trans women. In May, the study was stopped early when a planned interim analysis showed that those randomized to take doxycycline had substantially fewer STIs.
|
|
|
The NIH National Institute of Allergy and Infectious Diseases (NIAID) funded the trial through grant number R01AI143439. The study was conducted at the HIV clinic at Zuckerberg San Francisco General Hospital and the San Francisco City Clinic, both part of the San Francisco Department of Public Health, and the Madison Clinic and the Sexual Health Clinic at Harborview Medical Center, both at the University of Washington. Pictures of the San Francisco Study teams are below:
|
|
|
We have provided key slides from Dr. Luetkemeyer’s AIDS 2022 Late breaker abstract presentation with brief summaries.
Study Design:
|
|
|
Participants in the study were male sex at birth, living with HIV or taking HIV pre-exposure prophylaxis (PrEP) and had a history of an STI and condomless sex with a male partner within in the past year. They were randomized 2:1 to take open-label doxycycline after condomless sex versus continued standard of care without doxycycline.
Primary Results:
|
|
|
Among the 327 participants on PrEP, there was a 66% reduction in new STIs per quarter (doxycycline 10.7% versus control 31.9%, p<0.001). Of the 174 participants living with HIV, there was a 62% reduction per quarter with doxycycline (11.8% vs 30.5%, p<0.0001).
Summary of Results:
|
|
|
Manage your preferences | Opt Out using TrueRemove™
Got this as a forward? Sign up to receive our future emails.
View this email online.
|
1700 Owens Street | San Francisco, CA 94158 US
|
|
|
This email was sent to .
To continue receiving our emails, add us to your address book.
|
| |
|
|
