Drs. Timothy Sterling, Bruno Andrade (Instituto Brasileiro para Investigação da Tuberculose (IBIT), Salvador, Brazil), and Thomas Hawn (University of Washington) have just received a 5-year R01 grant from the National Institutes of Health entitled, “Immunogenetic predictors of active and incipient TB in HIV-negative and -positive close TB contacts” (R01AI147765). This was in response to PAR-16-254, "Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and Uninfected Individuals to Inform Innovative Tuberculosis Vaccine Design (R01)". Total funding awarded for the 5-year project is $3.6 million, with subcontracts to the Fundação para o Desenvolvimento Científico e Tecnológico em Saúde (FIOTEC; Brazil), the University of Washington, and the University of Cape Town (South Africa). This grant project seeks to understand the protective and predisposing factors for progression from M. tuberculosis infection to TB disease.