The first three Clade I mpox cases in the U.S. without known international travel have been identified in Los Angeles County. The California Department of Public Health (CDPH) has issued a health advisory in response.
Clade I mpox can cause severe illness, especially among individuals with weakened immune systems, who are at highest risk for severe disease and hospitalization.
The Los Angeles County Department of Public Health is collaborating closely with Long Beach Health and Human Services, California Department of Public Health, and the U.S. Centers for Disease Control and Prevention to investigate these mpox cases as swiftly and effectively as possible.
Providers should stay vigilant for mpox symptoms in their patients and perform timely testing. Visit the LAC DPH mpox provider hub for local resources related to vaccination, testing, treatment, and reporting.
Healthcare providers must report all confirmed or suspected clade I mpox immediately by phone. Consultation is also available. Report all mpox or orthopoxvirus infections, hospitalizations, and deaths within 1 working day from identification.
