Vanderbilt University | School of Medicine – Basic Science

“The Reading List” in dark teal with a drawing, in gold tones, of a person with long hair, sitting cross legged and reading a book.

First or corresponding authors are identified with an asterisk. Faculty with primary appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.

Week of March 4

By Basic Sciences department

Biochemistry

A small molecule that inhibits the evolution of antibiotic resistance. NAR Molecular Medicine.
Juan Carvajal-Garcia, Harrison Bracey, Anna Johnson, Angel Hernandez Viera, Martin Egli, Esra Simsek, Emily Jaremba, Kwangho Kim, Houra Merrikh*.

Highlighted on the Basic Sciences website.
Oxygen-18 Labeling Reveals a Mixed Fe−O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie.
Kevin McCarty*, Yasuhiro Tateishi, Tatiana Hargrove, Galina Lepesheva, F. Peter Guengerich.

Highlighted on the Basic Sciences website.
Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA. Cell Reports.
Xiang Ye*, Lindsey Guerin, Ziche Chen, Suba Rajendren, William Dunker, Yang Zhao, Ruilin Zhang, Emily Hodges*, John Karijolich*.

“Here is a new study from my lab investigating mechanisms of gene expression used by the oncogenic virus KSHV,”John Karijolich.

Cell and Developmental Biology

Editorial overview: Functional specialization of the cytoskeleton in diverse cell types. Current Opinion in Cell Biology.
Adele Marston* (University of Edinburgh), Matthew Tyska*.

Molecular Physiology and Biophysics

The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport. Nature Structural & Molecular Biology.
Terunaga Nakagawa*.

Highlighted on the Basic Sciences website.
Mitochondria in disease: changes in shapes and dynamics. Trends in Biochemical Sciences.
Brenita Jenkins* (Pennsylvania State University), Kit Neikirk*, Annet Kirabo, Antentor Hinton Jr.*
Modelling patient drug exposure profiles in vitro to narrow the valley of death. Nature Reviews Bioengineering.
Catherine Leasure*, Gregor Neuert*.

Highlighted on the Basic Sciences website.

Other biomedical basic sciences papers

Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation. Digital Medicine.
Chao Yan*, Monika Grabowska*, Alyson Dickson, Bingshan Li, Dan Roden, Michael Stein, Peter Embí, Josh Peterson, QiPing Feng, Bradley Malin, Wei-Qi Wei*.

Highlighted in The VUMC Reporter.
Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA. Cell Reports.
Xiang Ye*, Lindsey Guerin, Ziche Chen, Suba Rajendren, William Dunker, Yang Zhao, Ruilin Zhang, Emily Hodges*, John Karijolich*.

“Here is a new study from my lab investigating mechanisms of gene expression used by the oncogenic virus KSHV,”John Karijolich.
Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations. Membranes.
Anna Miranda Moura* (Campbellsville University), Charles Sanders.
Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift. Cancer Medicine.
Mohammed Tantawy*, Oliver McIntyre, Fiona Yull, Wade Calcutt, Dmitry Koktysh, Andrew Wilson, Zhongliang Zu, Jeff Nyman, Julie Rhoades, Todd Peterson, Daniel Colvin, Lisa McCawley, Jerri Rook, Barbara Fingleton, Marta Ann Crispens, Ronald Alvarez, John Gore.

Highlighted in the VUMC Reporter.
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry. Science Advances.
Fabian Bock*, Xinyu Dong, Shensen Li, Olga Viquez, Eric Sha, Matthew Tantengco, Elizabeth Hennen, Erin Plosa, Kyle Brown, Young Mi Whang, Andrew Terker, Juan Pablo Arroyo, David Harrison, Agnes Fogo, Ambra Pozzi, Roy Zent*.

Highlighted in the VUMC Reporter.

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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
Phone: (615) 322-0907 | basicsciences@vanderbilt.edu

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