Regular PMI seminar series- room 214 Light Hall, 12:00pm 09/15 Jin Chen, MD,PhD 09/22 Edward Sherwood, MD,PhD 10/06 Leslie Crofford, MD
RIP(Research in Progress) Research in Progress Calendar 09/04 Katie Nicholas (Kalams lab) 10/23 Sarah Katen(Dermody lab) 10/30 Ernest Yufenyuy(Aiken lab) NOTE: Dates in November and December are being set aside for Microbiology and Immunology qualifying Exams
Immunology Journal Club Immunology Journal Club Calendar 09/05 Amy Major, Ph.D. 09/12 Cara Wogsland 09/19 Jillian Rhoads 09/26 Tim Hill 10/03 Keunwook Lee,Ph.D.
MPHI Journal Club
PEDs ID Seminar Peds ID Calendar 2014-15 09/12 - Terence S. Dermody, M.D. 10/10 Aravinda de Silva, Ph.D.
HPI DIVISION ANNOUNCEMENTS:
We extend a warm welcome to 3 new faculty joining our division: Dr. Jim Cassat, Dr. Manuel (Mani) Ascano, Dr. Leslie Crofford and Dr. Jonathan Schmitz. We are delighted to have you in our ranks.29 publications have appeared on Pubmed from primary and secondary members of HPIHPI Division Meeting: September 30, 2014 at 3pm, MCN A5305. 2nd Friday Happy Hour: 09/12 at MCN A5305, 4:00pm - Hosted by the Aiken and Link Labs
Featured Publication:
"Endothelial JAM-A Promotes Reovirus Viremia and Bloodstream Dissemination" - Lai et al., JID 2014, Aug. 22. In this publication Lai et al. determined the contribution of the endothelial and hematopoietic Junctional Adhesion Molecule A (JAM-A) to dissemination of Reovirus. Many viruses spread systemically by bloodstream routes to reach infection sites. Knowledge gained from studies to determine precisely how viruses disseminate can be used to block this key step in viral pathogenesis and improve vector targeting for clinical applications. Reoviruses are non-enveloped, double-stranded RNA viruses that are being tested in Phase I-III clinical trial as anti-cancer (oncolytic) agents.
JAM-A is one of the mammalian receptors recognized by reoviruses and it is required for establishment of viremia and subsequent bloodstream spread to sites of secondary replication of all reovirus serotypes. This study used mice with tissue-specific alterations in JAM-A expression to assess hematogenous reovirus spread. Lai et al . demonstrated that endothelial JAM-A is required for reovirus trasmission. Given that reoviruses are excellent candidates for use as oncolytic agents, studies like those of Lai et al. , can provise insights into the design of new reovirus vectors that can reach target tumors more efficiently.
Our Publications - September
1. The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice. Canavaci AM, Sorgi CA, Martins VP, Morais FR, de Sousa EV, Trindade BC, Cunha FQ, Rossi MA, Aronoff DM, Faccioli LH, Nomizo A. Mediators Inflamm. 2014;2014:893634 9. Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Engler DB, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover TL, Taube C, Müller A. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11810-5. 10. STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge. Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE Jr, Boyd KL, Moore ML, Zhou W, Peebles RS Jr. J Virol. 2014 Sep 1;88(17):9655-72. 15. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis E Sousa C. Nature. 2014 Aug 10. doi: 10.1038/nature13590. 16.Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. Drake WP, Oswald-Richter K, Richmond BW, Isom J, Burke VE, Algood H, Braun N, Taylor T, Pandit KV, Aboud C, Yu C, Kaminski N, Boyd AS, King LE. JAMA Dermatol. 2013 Sep;149(9):1040-9. 17.Phase I Safety, Pharmacokinetics, and Pharmacogenetics Study of the Antituberculosis Drug PA-824 with Concomitant Lopinavir-Ritonavir, Efavirenz, or Rifampin. Dooley KE, Luetkemeyer AF, Park JG, Allen R, Cramer Y, Murray S, Sutherland D, Aweeka F, Koletar SL, Marzan F, Bao J, Savic R, Haas DW; AIDS Clinical Trials Group A5306 Study Team. Antimicrob Agents Chemother. 2014 Sep;58(9):5245-52. 19.OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis. Finak G, Frelinger J, Jiang W, Newell EW, Ramey J, Davis MM, Kalams SA, De Rosa SC, Gottardo R. PLoS Comput Biol. 2014 Aug 28;10(8):e1003806. 20.Emergence of broadly neutralizing antibodies and viral co-evolution in two subjects during the early stages of infection with the human immunodeficiency virus type 1. Sather DN, Carbonetti S, Malherbe D, Pissani F, Stuart AB, Hessell AJ, Gray MD, Mikell I, Kalams SA, Haigwood NL, Stamatatos L. J Virol. 2014 Aug 13. pii: JVI.01816-14. 23.Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia. Achouiti A, Vogl T, Endeman H, Mortensen BL, Laterre PF, Wittebole X, van Zoelen MA, Zhang Y, Hoogerwerf JJ, Florquin S, Schultz MJ, Grutters JC, Biesma DH, Roth J, Skaar EP, van 't Veer C, de Vos AF, van der Poll T. Thorax. 2014 Sep 1. pii: thoraxjnl-2014-205668. doi: 10.1136/thoraxjnl-2014-205668. 24. Transferrin iron starvation therapy for lethal bacterial and fungal infections. Lin L, Pantapalangkoor P, Tan B, Bruhn KW, Ho T, Nielsen T, Skaar EP, Zhang Y, Bai R, Wang A, Doherty TM, Spellberg B. J Infect Dis. 2014 Jul 15;210(2):254-64. doi: 10.1093/infdis/jiu049. 27. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM Jr, Fox JG, Woster PM, Casero RA Jr, Correa P, Wilson KT. Oncogene. 2014 Sep 1. doi: 10.1038/onc.2014.273. 28. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM Jr. Gut. 2014 Aug 14. pii: gutjnl-2014-307650. doi: 10.1136/gutjnl-2014-307650. 29. Heme Oxygenase-1 Dysregulates Macrophage Polarization and the Immune Response to Helicobacter pylori. Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM Jr, Chaturvedi R, Wilson KT, J Immunol. 2014 Aug 8. pii: 1401075.
What are your thoughts? Feel free to muse by sending us an email (maria.hadjifrangiskou@vanderbilt.edu, helen.chomicki@vanderbilt.edu)
