Vanderbilt University | School of Medicine – Basic Science

“The Reading List” in dark teal with a drawing, in gold tones, of a person with long hair, sitting cross legged and reading a book.

First or corresponding authors are identified with an asterisk. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.

Week of June 10

By Basic Sciences department

Biochemistry

Multimodal MALDI imaging mass spectrometry for improved diagnosis of melanoma. PLOS One.
Wanqiu Zhang* (KU Leuven), Nathan Patterson, Richard Caprioli, Jeremy Norris.
STOPGAP: an open-source package for template matching, subtomogram alignment and classification. Acta Crystallographica Section D: Structural Biology.
William Wan*.

Weekly Coordinates: STOP the GAP: New cryo-ET package aims to fill in the ‘missing wedge’.
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP. Science Signaling.
Lavinia Palamiuc, Zeinab Haratipour, Woong Jae Choi, Raymond Blind*.
Roles of Ferric Peroxide Anion Intermediates (Fe3+O2-, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model. Angewandte Chemie International Edition.
Yasuhiro Tateishi, Kevin McCarty, Martha Martin, F. Peter Guengerich.

Cell and Developmental Biology

GammaGateR: semi-automated marker gating for single-cell multiplexed imaging. Bioinformatics.
Jiangmei Xiong*, Harsimran Kaur, Cody Heiser, Eliot McKinley, Joseph Roland, Robert Coffey, Martha Shrubsole, Siyuan Ma, Ken Lau, Simon Vandekar*.
Resolution of acinar dedifferentiation regulates tissue remodeling in pancreatic injury and cancer initiation. Gastroenterology.
Jonathan Baldan* (Vrije Universiteit Brussel), Juan Camacho-Roda* (University of Copenhagen), Marta Ballester* (University of Copenhagen), Kathleen DelGiorno.

Molecular Physiology and Biophysics

Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B-type natriuretic peptide hormone: Results from a randomized controlled crossover study. Diabetes, Obesity and Metabolism.
Katherine Bachmann*, Ryan Ceddia*, Deepak Gupta, Sheila Collins.

VUMC News: VUMC-led team reports potential new way to stimulate weight loss.

Pharmacology

Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacology and Translational Science.
Shannon Smith*, Jackson Cassada, Lukas Von Bredow, Kevin Erreger, Emma Webb, Trevor Trombley, Jacob Kalbfleisch, Irene Zagol-Ikapitte, Valerie Kramlinger, Jacob Bouchard, Sidnee Mitchell, Craig Lindsley, Jens Meiler*, Heidi Hamm*.

Basic Sciences: New drug candidates targeting blood clots developed through computer-aided drug design.

Other basic biomedical papers

The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis (preprint). bioRxiv.
Jonathan Davies, Lars Plate.

“We find that CoVs, like SARS-CoV-2, use malectin (part of cells’ glycoprotein production assembly line) to make viral proteins and replicate. Malectin may be a prime pan-CoV antiviral target!” Lars Plate.

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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
Phone: (615) 322-0907 | basicsciences@vanderbilt.edu

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