MP faculty publications: September 2023

1. Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.

   Gres AT, Kirby KA, McFadden WM, Du H, Liu D, Xu C, Bryer AJ, Perilla JR, Shi J, Aiken C, Fu X, Zhang P, Francis AC, Melikyan GB, Sarafianos SG. Nat Commun. 2023 Sep 12;14(1):5614.

2. Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy

   Garland KM, Kwiatkowski AJ, Tossberg JT, Crooke PS 3rd, Aune TM, Wilson JT. Cancer Res Commun. 2023 Sep 8;3(9):1800-1809.

3. Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

   Middha P, Thummalapalli R, Betti MJ, Yao L, Quandt Z, Balaratnam K, Bejan CA, Cardenas E, Falcon CJ, Faleck DM; Princess Margaret Lung Group; Gubens MA, Huntsman S, Johnson DB, Kachuri L, Khan K, Li M, Lovly CM, Murray MH, Patel D, Werking K, Xu Y, Zhan LJ, Balko JM, Liu G, Aldrich MC, Schoenfeld AJ, Ziv E. medRxiv [Preprint]. 2023 Sep 13:2023.05.15.23289680.

4. Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

   Chapman NS, Hulswit RJG, Westover JLB, Stass R, Paesen GC, Binshtein E, Reidy JX, Engdahl TB, Handal LS, Flores A, Gowen BB, Bowden TA, Crowe JE Jr. Nat Commun. 2023 Sep 13;14(1):5650.

5. Host range, transmissibility and antigenicity of a pangolin coronavirus

   Hou YJ, Chiba S, Leist SR, Meganck RM, Martinez DR, Schäfer A, Catanzaro NJ, Sontake V, West A, Edwards CE, Yount B, Lee RE, Gallant SC, Zost SJ, Powers J, Adams L, Kong EF, Mattocks M, Tata A, Randell SH, Tata PR, Halfmann P, Crowe JE Jr, Kawaoka Y, Baric RS. Nat Microbiol. 2023 Oct;8(10):1820-1833.

6. Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals

   Desine S, Gabriel CL, Smith HM, Antonetti OR, Wang C, Calcutt MW, Doran AC, Silver HJ, Nair S, Terry JG, Carr JJ, Linton MF, Brown JD, Koethe JR, Ferguson JF. Front Endocrinol (Lausanne). 2023 Sep 7;14:1122391.

7. Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

   McLaren PJ, Porreca I, Iaconis G, Mok HP, Mukhopadhyay S, Karakoc E, Cristinelli S, Pomilla C, Bartha I, Thorball CW, Tough RH, Angelino P, Kiar CS, Carstensen T, Fatumo S, Porter T, Jarvis I, Skarnes WC, Bassett A, DeGorter MK, Sathya Moorthy MP, Tuff JF, Kim EY, Walter M, Simons LM, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, De Luca A, Goedert JJ, Goldstein DB, Haas DW, Herbeck JT, Johnson EO, Kaleebu P, Kilembe W, Kirk GD, Kootstra NA, Kral AH, Lambotte O, Luo M, Mallal S, Martinez-Picado J, Meyer L, Miro JM, Moodley P, Motala AA, Mullins JI, Nam K, Obel N, Pirie F, Plummer FA, Poli G, Price MA, Rauch A, Theodorou I, Trkola A, Walker BD, Winkler CA, Zagury JF, Montgomery SB, Ciuffi A, Hultquist JF, Wolinsky SM, Dougan G, Lever AML, Gurdasani D, Groom H, Sandhu MS, Fellay J. Nature. 2023 Sep;621(7979):E42.

8. The Tennessee Center for AIDS Research HIV Research Training Program for Minority High School and Undergraduate Students: Development, Implementation, and Early Outcomes

   Koethe JR, Eeds A, Stewart LV, Haas DW, Hildreth JEK, Mallal S, Wanjalla C, Perkins J, Ahonkhai A, Dong X, Berhanu R, Dash C. J Acquir Immune Defic Syndr. 2023 Oct 1;94(2S):S42-S46

9. The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

   Hurst MN, Beebout CJ, Hollingsworth A, Guckes KR, Purcell A, Bermudez TA, Williams D, Reasoner SA, Trent MS, Hadjifrangiskou M. mSphere. 2023 Sep 7:e0005923.

10. Erratum for Humphries et al., "CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests"

    Humphries RM, Ambler J, Mitchell SL, Castanheira M, Dingle T, Hindler JA, Koeth L, Sei K; J Clin Microbiol. 2023 Sep 21:e0073923.

11. Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS).

    Stahl M, Bewersdorf JP, Xie Z, Porta MGD, Komrokji R, Xu ML, Abdel-Wahab O, Taylor J, Steensma DP, Starczynowski DT, Sekeres MA, Sanz G, Sallman DA, Roboz GJ, Platzbecker U, Patnaik MM, Padron E, Odenike O, Nimer SD, Nazha A, Majeti R, Loghavi S, Little RF, List AF, Kim TK, Hourigan CS, Hasserjian RP, Halene S, Griffiths EA, Gore SD, Greenberg P, Figueroa ME, Fenaux P, Efficace F, DeZern AE, Daver NG, Churpek JE, Carraway HE, Buckstein R, Brunner AM, Boultwood J, Borate U, Bejar R, Bennett JM, Wei AH, Santini V, Savona MR, Zeidan AM. Blood Rev. 2023 Aug 19:101128.

12. Prognostic value of European Leukemia Net 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia

    Park S, Kim TY, Cho BS, Kwag D, Lee JM, Kim M, Kim Y, Koo J, Raman A, Kim TK, Kim HJ. Haematologica. 2023 Sep 14.

13. Understanding and treatment of cutaneous graft-versus-host-disease

    Hong J, Fraebel J, Yang Y, Tkacyk E, Kitko C, Kim TK. Bone Marrow Transplant. 2023 Sep 20

14. Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB

    Childress KO, Cencer CS, Tyska MJ, Lacy DB. mBio. 2023 Sep 25:e0185723.

15. Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis

    Appleton BD, Palmer SA, Smith HP, Stephens LE, Major AS. Arterioscler Thromb Vasc Biol. 2023 Sep 7

16. Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV

    Bailin SS, Kropski JA, Gangula RD, Hannah L, Simmons JD, Mashayekhi M, Ye F, Fan R, Mallal S, Warren CM, Kalams SA, Gabriel CL, Wanjalla CN, Koethe JR. Front Immunol. 2023 Aug 30;14:1152003

17. Corrigendum: The potential relationship between environmental endocrine disruptor exposure and the development of endometriosis and adenomyosis

    Stephens VR, Rumph JT, Ameli S, Bruner-Tran KL, Osteen KG. Front Physiol. 2023 Aug 14;14:1260961.

18. Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics

    Kim M, McDonald EF, Sabusap CMP, Timalsina B, Joshi D, Hong JS, Rab A, Sorscher EJ, Plate L. J Biol Chem. 2023 Sep 8:105242

19. BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels

    Han D, Schaffner SH, Davies JP, Benton ML, Plate L, Nordman JT. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2305092120.

20. CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine.

    McDonald EF, Meiler J, Plate L. ACS Chem Biol. 2023 Sep 20

21. Maintenance of heme homeostasis in Staphylococcus aureus through post-translational regulation of glutamyl-tRNA reductase

    Leasure CS, Grunenwald CM, Choby JE, Sauer JD, Skaar EP. J Bacteriol. 2023 Sep 26;205(9):e0017123.

22. Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    Critchlow JT, Prakash A, Zhong KY, Tate AT. bioRxiv [Preprint]. 2023 Aug 14:2023.08.10.552815.

23. SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells

    Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Hengstschläger M, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ. Sci Transl Med. 2023 Sep 13;15(713):eade2581.

24. Diversity and taxonomic distribution of bacterial biosynthetic gene clusters predicted to produce compounds with therapeutically relevant bioactivities

    Beck ML, Song S, Shuster IE, Miharia A, Walker AS. J Ind Microbiol Biotechnol. 2023 Aug 31:kuad024.

25. Artificial intelligence for natural product drug discovery

    Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Nat Rev Drug Discov. 2023 Sep 11.

26. Retrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in TNF signaling

    Zhang H, Patrick MT, Tejasvi T, Sarkar MK, Wasikowski R, Stuart PE, Li Q, Xing X, Voorhees JJ, Ward NL, He K, Zhou X, Gudjonsson JE, Nair RP, Elder JT, Tsoi LC. Br J Dermatol. 2023 Sep 6:ljad332.

27. Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing

    Pagendarm HM, Stone PT, Kimmel BR, Baljon JJ, Aziz MH, Pastora LE, Hubert L, Roth EW, Almunif S, Scott EA, Wilson JT Nanoscale. 2023 Sep 27.