Forwarded by the Los Angeles County Department of Public Health
| CDPH Health Update:
Update on Bicillin® L-A (penicillin G benzathine injectable suspension) Shortage: Inventory Review and Clinical Guidance
February 25, 2026
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The California Department of Public Health (CDPH) has issued a Health Update to inform healthcare providers about the Bicillin L-A shortage and to provide medication alternatives for the treatment of syphilis.
CDPH Key Messages:
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Pfizer recently updated (PDF) the estimated recovery of the Bicillin L-A shortage to the 4th Quarter of 2026.
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The next delivery of Bicillin® L-A 1.2 MU and 2.4 MU prefilled syringes is anticipated to be in July 2026; the next delivery of the pediatric 600,000 Units prefilled syringes is expected to be in December 2026.
- Health care providers and entities should continue to prioritize long-acting penicillin-based treatments (Bicillin® L-A & Lentocilin®) for the treatment of pregnant people with syphilis and infants exposed to syphilis in utero.
- Extencilline® is no longer available for distribution.
- Oral doxycycline is an acceptable alternative treatment for non-pregnant adults with primary, secondary, early/late latent syphilis and syphilis of unknown duration.
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To view this and other communications or to sign-up to receive LAHANs, please visit ph.lacounty.gov/lahan.
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