The Reading List will be on hiatus until Jan. 13, 2025. Happy holidays!

By Basic Sciences department

Biochemistry

• West African Genetic Ancestry and Breast Cancer Outcomes Among Black Women. JAMA Network Open.
  Sonya Reid*, Run Fan, Lindsay Venton, Anne Weidner, Ann Tezak, Jibril Hirbo, Jennifer Whisenant, Jennifer Pietenpol, Brian Lehmann, Fei Ye, Tuya Pal*.
  
  
• Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease. Investigative Ophthalmology & Visual Science.
  Bushra Rahman* (Medical University of South Carolina), David Anderson, Kevin Schey.
  
  
• Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. eLife.
  Jinsai Shang* (Guangzhou Medical University), Douglas Kojetin*.
  
  Science: PPAR Binding Strikes Again
  
  SBGrid Community News: Recent discoveries set the stage for new treatments for diabetes and other metabolic disorders
  
  Center for Structural Biology: Unmasking antagonists: a deep dive into the structural binding poses of PPARγ ligands
  

Cell and Developmental Biology

• Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete. The Journal of Antibiotics.
  Jordan Froese* (Ball State University), Joseph Balsamo*, Benjamin Reisman, Sierra Barone, Jonathan Irish, Brian Bachmann*.
  
  
• A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research. Journal of Extracellular Vesicles.
  Sun Young Lee* (University of Southern California, Los Angeles), Alissa Weaver*.
  

Molecular Physiology and Biophysics

• The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses. Frontiers in Immunology.
  Victoria Stephens*, Sabrina Spicer, Riya Chinni, Antentor Hinton Jr., Steven Damo, Alison Eastman, Kevin Osteen, Jennifer Gaddy*.
  
  
• Loss of β-cell KATP reduces Ca²⁺ sensitivity of insulin secretion and Trpm5 expression. Diabetes.
  Nathaniel York* (Washington University in St. Louis), Anna Osipovich, Mark Magnuson.
  

Pharmacology

• Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease. Journal of Medicinal Chemistry.
  Tomayo Berida*, Craig Lindsley*.
  
  
• Discovery of VU0467319: an M₁ Positive Allosteric Modulator Candidate That Advanced into Clinical Trials. ACS Chemical Neuroscience.
  Michael Poslunsey*, Michael Wood, Changho Han, Shaun Stauffer, Joseph Panarese, Bruce Melancon, Julie Engers, Jonathan Dickerson, Weimin Peng, Meredith Noetzel, Hyekyung Cho, Alice Rodriguez, Corey Hopkins, Ryan Morrison, Rachel Crouch, Thomas Bridges, Anna Blobaum, Olivier Boutaud, Scott Daniels, Jerri Rook, Colleen Niswender, Carrie Jones, Jeffrey Conn, Craig Lindsley*.
  
  
• Discovery of VU6024578/BI02982816: An mGlu₁ Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models. Journal of Medicinal Chemistry.
  Carson Reed*, Jacob Kalbfleisch, Jeremy Turkett, Trevor Trombley, Anthony Nastase, Paul Spearing, Daniel Haymer, Mohammad Sarwar, Marc Quitalig, Jonathan Dickerson, Annie Blobaum, Olivier Boutaud, Hyekyung Cho, Colleen Niswender, Jerri Rook, Jeffrey Conn, Bruce Melancon, Craig Lindsley*.
  

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