By Basic Sciences department

Biochemistry

• TOMOMAN: a software package for large-scale cryo-electron tomography data preprocessing, community data sharing and collaborative computing. Journal of Applied Crystallography.
  Sagar Khavnekar* (Max Planck Institute of Biochemistry), William Wan*.
  

Cell and Developmental Biology

• Alterations in cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation. American Journal of Physiology-Gastrointestinal and Liver Physiology.
  Michael Momoh*, Sudiksha Rathan-Kumar*, Andreanna Burman, Monica Brown, Francisca Adeniran, Cynthia Ramos, James Goldenring, Joseph Roland, Izumi Kaji*.
  
  
• The Greatwall-Endosulfine-PP2A/B55 pathway regulates entry into quiescence by enhancing translation of Elongator-tunable transcripts. Nature Communications.
  Javier Encinar Del Dedo* (University of Salamanca), Jun-Song Chen, Kathleen Gould.
  

Molecular Physiology and Biophysics

• Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake (preprint). bioRxiv.
  Jacob Myers*, Woo Yong Park, Alexander Eddie, Abhijit Shinde, Michael Leonard, Julia Pinette, Jessica Rampy, Claudia Montufar, Zayedali Shaikh, Tara Hickman, Garrett Reynolds, Nathan Winn, Louise Lantier, Sun Peck, Katie Coate, Roland Stein, Nancy Carrasco, Erin Calipari, Elma Zaganjor*.
  
  
• Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors. Diabetes.
  Hannah Waterman*, Mary Courtney Moore, Marta Smith, Ben Farmer, Kalisha Yankey, Melanie Scott, Dale Edgerton, Alan Cherrington.
  
  
• Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy. PNAS.
  Alexandra Schwartz*, Richard Stein, Hassane Mchaourab*.
  
  Basic Sciences: Research Snapshot: Spectroscopy and AI method provide unique window into protein structure and mechanism of action
  

Pharmacology

• Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist. Angewandte Chemie International Edition.
  Philipp Leippe* (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences), Prashant Donthamsetti*.
  
  
• N-Aldehyde-Modified Phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-Acyl Phosphatidylethanolamine Phospholipase D (preprint). bioRxiv.
  Reza Fadaei, Annie Bernstein, Jonah Zarrow, Abdul-Musawwir Alli-Oluwafuyi, Keri Tallman, Sean Davies.
  
  
• Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate. PLOS Pathogens.
  Gang Ye* (University of Minnesota Medical School), Fan Bu* (University of Minnesota Medical School), Divyasha Saxena* (University of Louisville), Benjamin Spiller, Brian Wadzinski.
  
  
• Natural Products Driven Medicinal Chemistry. Journal of Medicinal Chemistry.
  Sandip Bharate* (CSIR-Indian Institute of Chemical Technology), Craig Lindsley*.
  

Other basic biomedical papers

• Germline genetics, disease, and exposure to medication influence longitudinal dynamics of clonal hematopoiesis. Haematologica.
  Taralynn Mack*, Yash Pershad, Cosmin Bejan, Jonathan Brett Heimlich, Yajing Li, Nicole Mickels, Joseph Van Amburg, Jessica Ulloa, Alexander Silver, Leo Luo, Angela Jones, Paul Brent Ferrell, Ashwin Kishtagari, Yaomin Xu, Michael Savona, Alexander Bick.
  
  VUMC News: Potential treatment eyed for abnormal blood cell disorder
  
  
• Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses. Nucleic Acids Research.
  Jingni He* (University of Calgary), Wanqing Wen, Jie Ping, Qing Li, Linshuoshuo Lyu, Zhishan Chen, Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Zhijun Yin, Wei Zheng, Xingyi Guo*.
  
  VUMC News: Novel genetics approach enhances discovery of disease risk genes
  

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