As we move into the second year of the nutrition project, future work will be centered around a few of the Potentially Better Practices (PBPs) from the tool kit sections on enteral nutrition.
The first PBP focuses on the early initiation of enteral feedings. These minimal enteral feedings (5-25 ml/kg/day) should be initiated within 1-2 days of birth except when there are clear contraindications such as a congenital anomaly precluding feeding (for example, omphalocele or gastroschisis), or evidence of GI dysfunction (as with hypoxic-ischemic compromise or shock). Early enteral feedings stimulate gut maturation, hormone release and motility. Beneficial effects of minimal enteral feedings include shorter time to full feeds, faster weight gain, less feeding intolerance, less need for phototherapy, enhanced maturation of small intestine function, decreased length of stay, significant reduction in serious infections, and a lower incidence of extrauterine growth restriction.
The second PBP discusses that enteral feedings should be advanced until they are providing adequate nutrition to sustain optimal growth, ideally 15-20 grams/kg/day. For infants who are being fed human milk, this could mean an intake higher than the historic 150 ml/ky/day, depending on the caloric density of the mom's or donor's milk, given to these infants in order to establish optimal growth. The total feeding volume should be individualized to each baby to achieve optimal growth.
References:
Friel JK, Aqndrews WL, Matthew JD et al. (1993). Improved growth of very low birthweight infants. Nutr Res, 12:611-620.
Kuschel CA, Evans N, Askie L, Bredemeyer S, Nash J, Polverino J. (2000). randomized trial of enteral feeding volumes in infants born before 30 weeks’ gestation. J Paediatr Child Health, 36(6):581-586.
Lucas A, Bloom SR, Aynsley-Green A. (1986). Gut hormones and ‘minimal enteral feeding’. Acta Paediatr Scand 75(5):719-23.
Stevens T, et al (2016). Variation in Enteral Feeding Practices and Growth Outcomes among very premature infants: A report from the New York State Perinatal Quality Collaborative. Amer J Perinatol, 33(1), 9-19.
Thureen PJ, Hay WW Jr. (2001). Early aggressive nutrition in preterm infants. Semin. Neonatol, 6(5): 403-15.
Ziegler EE, Thureen PJ, Carlson SJ. (2002). Aggressive nutrition of the very low birthweight infant. Clin Perinatol, 29:225-244.