The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
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A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein. Cell Reports Medicine.
Alexandra Abu-Shmais*, Alexis Janke, Matthew Vukovich, Lindsay Bass, Yukthi Suresh, Rachael Wolters, Nurgun Kose, Robert Carnahan, James Crowe Jr., Rachel Bonami, Ivelin Georgiev*.
VUMC News: Vanderbilt Health team finds potent antibody that neutralizes two dangerous viruses -
Norepinephrine derepresses the Fur regulon of Neisseria gonorrhoeae to enable growth in iron-limited conditions. Journal of Bacteriology.
Camille Westlake* (University of Virginia), Indu Bhatia, Yasiru Perera, Walter Chazin.
Featured as an “Editor’s pick” paper by the journal. -
Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution. Protein Science.
Galina Lepesheva*, Tatiana Hargrove, Yi Ren.
Supported by the Cryo-EM Facility. - Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy. eLife.
Liudmyla Arifova*, Zane Laughlin, Mithun Nag Karadi Girdhar, Min-Hsuan Li, Xiaoyu Yu, Douglas Kojetin*. -
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity. Journal of Virology.
Parker Jamieson*, Alexandra Abu-Shmais, Perry Wasdin, Lindsay Bass, Naveenchandra Suryadevara, Ty Sornberger, Seth Zost, Alexis Janke, Bethany Howard, Yukthi Suresh, James Crowe Jr., Robert Carnahan, Rachel Bonami, Spyros Kalams, Ivelin Georgiev*.
Supported by the Cell Imaging Shared Resource. -
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity. Mucosal Immunology.
Jeffrey Maslanka* (University of Pennsylvania), Christopher Peritore-Galve, Borden Lacy.
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Department of Cell and Developmental Biology |
- Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function. Proceedings of the National Academy of Sciences.
Olga Viquez*, Meiling Melzer*, Shensen Li*, Matthew Tantengco*, Xinyu Dong, Eric Sha, Jeffery Huang, Evan Krystofiak, Rachel Hart, Wentian Luo, Al-Borhan Bayazid, Richard Zhang, Ryoichi Bessho, Volker Haase, Craig Brooks, Matthew Wilson, Andrew Terker, Juan Arroyo, Ambra Pozzi, Roy Zent, Fabian Bock*.
Supported by the Cell Imaging Shared Resource.
VUMC News: Protein plays dual roles in repairing damaged kidney. -
Building consensus: construction of a juvenile and adult scRNA-seq meta-atlas for dataset comparisons and harmonizing transcriptomic definitions of enteric neuron subtypes. BMC Genomics.
Joseph Benthal*, Michelle Southard-Smith*. -
Deregulated translation of the transcription factor Myt3 predisposes islet β-cells to dysfunction under obesity-induced metabolic stress. Journal of Biological Chemistry.
Ruiying Hu*, Yu Wang, Mahircan Yagan, Yanwen Xu, Alan Simmons, Ken Lau, Qi Liu, Guoqiang Gu*. -
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility. Nature Communications.
Zhishan Chen*, Wenqiang Song*, Qing Li*, Chao Li, Wanqing Wen, Qiuyin Cai, Jifeng Wang, Jiajun Shi, Jirong Long, Jie Ping, Gong Yang, Luc Van Kaer, Lan Wu, Bingshan Li, Xiao-Ou Shu, Ken Lau, Wei Zheng, Xingyi Guo*. -
Wnt signaling is modulated by the buffer-like properties of cadherins. Molecular Biology of the Cell.
Lauren Schnitkey*, Christin Anthony*, Matthew Loberg, Gemma Orton, Allison McCabe, Jonathan Trapani, Mary Rockouski, Joyce Luo, Sheau-Chiann Chen, Fei Ye, Vivian Weiss, Ethan Lee*. -
Spef1 is a microvillar component that limits apical actomyosin contractility and preserves intestinal barrier function. Current Biology.
Rocio Tapia*, Angelo Morales, Matthew Tyska*. - Visualizing Postsynaptic Density in Excitatory Synapses with Electron Tomography (chapter). Advances in Neurobiology: Nano-organization of the Synapse: From Structure to Function.
Rong Sun*, Qiangjun Zhou*.
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Department of Molecular Physiology and Biophysics |
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Narrative review of mitochondrial dysfunction in aging-related salt-sensitive hypertension: outcomes, mechanisms, and therapeutic implications. Aging Advances.
Sepiso Masenga*, Joreen Povia* (Livingstone Center for Prevention and Translational Science), Ronald McMillian, Claude Albritton, Jeremiah Afolabi, Benjamin Rodriguez, Amber Crabtree, Salma AshShareef, Margaret Mungai, Han Le, Andrea Marshall, Kit Neikirk, Annet Kirabo, Antentor Hinton Jr.* -
Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging. Aging Advances.
C. Nivedya* (Indian Institute of Science Education and Research), Prasanna Venkhatesh* (Indian Institute of Science Education and Research), Benjamin Rodriguez*, Han Le, Jeremiah Afolabi, Andrea Marshall, Kit Neikirk, Sepiso Masenga, Muhammad Aftab, Leo Jake Kazma, Antentor Hinton Jr.* -
α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity. Molecular Metabolism.
Fabian Bock*, Xinyu Dong*, Kakali Ghoshal, David Cappel, John Deaver, Luciano Cozzani, Deanna Bracy, Louise Lantier, Allison Do, Richard Printz, Santosh Thapa, Owen McGuinness, David Wasserman, Ambra Pozzi, Roy Zent, Nathan Winn*.
Supported by the Vanderbilt Metabolic Mouse Phenotyping Center. -
Binding Entropy Can Be Predicted by Crystallographic Ensembles (preprint). bioRxiv.
Charlotte Miller*, Stephanie Wankowicz*. -
A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition. Journal of Developmental Biology.
Claudia Gil* (University of Texas at Arlington), Sepiso Masenga, Antentor Hinton Jr.
- Mitochondrial DNA Variation, Antiretroviral Therapy, and Incidence of Diabetes Among Men With and Without HIV. Open Forum Infectious Diseases.
Craig Cronin* (Johns Hopkins University), David Samuels, Todd Hulgan.
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Department of Pharmacology |
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Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimer’s & Dementia.
Alaina Durant*, Angela Jefferson, Logan Dumitrescu, Derek Archer, Timothy Hohman, Leslie Gaynor*.
VUMC News: Study finds so-called super agers tend to have at least two key genetic advantages. -
Nalmefene and naltrexone reduce alcohol intake via selective efficacy in subpopulations distinguished by behavioral and blood-based biomarkers. Communications Medicine.
Zahra Farahbakhsh*, Alex Brown*, Suzanne Nolan, Snigdha Mukerjee, Cody Siciliano*. -
General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants. eLife.
Austin Tedman* (Purdue University), John Olson III, Minsoo Kim, Eli McDonald, Jens Meiler, Lars Plate. - Deceptive beauty of non-natural structures. Protein Science.
Vsevolod Gurevich*, Eugenia Gurevich. -
Advances in Neurobiology: Nano-organization of the Synapse: From Structure to Function (book).
Ege Kavalali* (editor). -
Nano-organization of the Synapse: A Requisite Framework for Synaptic Signaling (chapter). Advances in Neurobiology: Nano-organization of the Synapse: From Structure to Function.
Ege Kavalali*. -
Synaptic Cell Adhesion: A Functional Perspective (chapter). Advances in Neurobiology: Nano-organization of the Synapse: From Structure to Function.
Kelly Honkanen*, Richard Sando*. -
Functional Nano-segregation of Distinct Forms of Neurotransmission (chapter). Advances in Neurobiology: Nano-organization of the Synapse: From Structure to Function.
Natalie Guzikowski*, Camille Wang, Ege Kavalali*. - Structural Basis for how Sialoglycan-binding Viridans Streptococci Accommodate Ligands that Exceed the Characterized Binding Site. microPublication Biology.
KeAndreya Morrison* (Meharry Medical College), Kole Martin, Tina Iverson*. -
The pathway-independent positive allosteric modulator C1 allows for the identification of active Y4 receptor relevant positions. Cellular and Molecular Life Sciences.
Corinna Schüß* (Leipzig University), Oanh Vu, Yu Du, C. David Weaver, Jens Meiler. -
Superwater as a generative AI framework to predict water molecule positions on protein structures. Communications Chemistry.
Xiaohan Kuang*, Yunchao Lance Liu, Xiaobo Lin, Jesse Spencer-Smith, Tyler Derr, Jens Meiler, Zhaoqian Su*. -
Phenotypic Variability and Paternal Inheritance of a CHD8 Variant Causing Intellectual Developmental Disorder With Autism and Macrocephaly Confirmed by Epigenetic and Structural Analyses. Molecular Genetics & Genomic Medicine.
Yutaka Furuta*, Kimberly Ezell, Rizwan Hamid, Joy Cogan, Thomas Cassini, Lynette Rives, Ashley McMinn, Shailee Shah, Amanda Peltier, Stephen Layfield, Christopher Moth, Jens Meiler, Sumit Pruthi, John Phillips III.
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Other Vanderbilt basic biomedical research |
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter. Please send the paper’s URL.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200, 465 21st Avenue South
Nashville, TN 37240
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