The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
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Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1. Nature Communications.
Briana Greer*, Javier Mendia-Garcia* (Centro Nacional de Biotecnología), Elwood Mullins*, Emma Peacock, Sander Haigh, Carl Schiltz, David Cortez, Brandt Eichman*.
Supported by the Cryo-EM Facility. -
Enzyme-DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs. ACS Infectious Diseases.
Jill Armenia*, Neil Osheroff*. -
Expression-Driven Genetic Dependency Reveals Targets for Precision Oncology. GigaScience.
Abdulkadir Elmas* (Icahn School of Medicine at Mount Sinai), Hillary Layden, Jacob Ellis, Luke Bartlett, Scott Hiebert.
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Department of Cell and Developmental Biology |
- Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization. Cellular and Molecular Gastroenterology and Hepatology.
Katherine Ankenbauer*, Yilin Yang, Brenda Jarvis, Jiayue Liu, Victoria Sarkisian, Neil Dani, Evan Krystofiak, Ken Lau, Kathleen DelGiorno*. -
The Stmn1-lineage contributes to acinar regeneration but not to neoplasia upon oncogenic Kras expression. Cellular and Molecular Gastroenterology and Hepatology.
Shakti Dahiya* (University of Pittsburgh Medical Center), Jorge Arbujas* (University of Pittsburgh Medical Center), Zhibo Ma, Celina Copeland, Kathleen DelGiorno.
Supported by the Cell Imaging Shared Resource. -
De novo design of phosphotyrosine peptide binders (preprint). bioRxiv.
Magnus Bauer* (University of Washington), Jason Zhang* (University of Washington), Kejia Wu* (University of Washington), Gyu Rie Lee* (University of Washington), Brian Coventry* (University of Washington), Isabella Silvestri*, Krishna Mudumbi*. -
PFAS Alter Thyroid Histology and Cellular Signaling In Vitro and In Vivo. Journal of the Endocrine Society.
Heather Hartmann*, Kailey Caroland, Goran Tumbic, Jessica Rampy, Hua-Chang Chen, Sheau-Chiann Chen, Clara Mannes, Claudia Wahoski, Matthew Loberg, Cynthia Liang, Diana Diaz, Megan Tigue, Quanhu Sheng, Fei Ye, Ethan Lee, Vivian Weiss*.
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Department of Pharmacology |
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Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. ACS Chemical Neuroscience.
Scott Henderson*, Anna Ringuette, David Whomble, Rory Capstick, Alexa Richardson, Mallory Maurer, Natasha Billard, Xia Lei, Joshua Wilkinson, Sri Kethanapalli, Hyekyung Cho, Alice Rodriguez, Colleen Niswender, Weimin Peng, Jerri Rook, Sichen Chang, Anna Blobaum, Olivier Boutaud, Andrew Felts, P Jeffrey Conn, Craig Lindsley*, Kayla Temple*. -
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy. ACS Chemical Neuroscience.
Alison Gregro*, Charlotte Park, Madeline Long, Logan Baker, Katrina Bollinger, Anna Ringuette, Li Peng, Vincent Luscombe, Natasha Billard, Alice Rodriguez, Colleen Niswender, Weimin Peng, Jonathan Dickerson, Jerri Rook, Jordan O'Neill, Sichen Chang, Thomas Bridges, Olivier Boutaud, P Jeffrey Conn, Darren Engers, Craig Lindsley*, Kayla Temple*.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter. Please send the paper’s URL.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200, 465 21st Avenue South
Nashville, TN 37240
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