The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Cortez, Bhowmick, Young win Chancellor’s Award for Research at 2025 Fall Faculty Assembly |
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Department of Biochemistry |
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A versatile enzymatic pathway for modification of peptide C-termini (preprint). bioRxiv.
Shravan Dommaraju*, Douglas Mitchell*.
Supported by the Mass Spectrometry Research Center. -
DNA double-strand break end resection factors and WRN facilitate mitotic DNA synthesis in human cells. Nature Communications.
Szymon Barwacz* (University of Copenhagen), Rahul Bhowmick. - Cooling-Triggered Release of Celecoxib from Implantable Alginate-Soluplus Composite Devices. ACS Biomaterials Science & Engineering.
Romario Lobban*, Michael Carroll, Victoria Vest, Josh McCune, Sarah Hall, Fang Yu, Md Jashim Uddin, Lawrence Marnett, Craig Duvall, Leon Bellan*. -
Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model. Journal of Medicinal Chemistry.
James Tarr*, Kyuok Jeon, Nagarathanam Veerasamy, James Salovich, Bin Zhao, John Sensintaffar, Danielle Sgubin, Allison Arnold, Rakesh Vekariya, Plamen Christov, Kwangho Kim, Mayme Van Meveren, Nagaraju Miriyala, Edward Olejniczak, Taekyu Lee, Stephen Fesik*.
Supported by the High-Throughput Screening Facility and the Molecular Design and Synthesis Center. -
Protocol for Disome-seq to identify transcriptome-wide ribosome collisions in yeast cells. STAR Protocols.
Pedro Ayres-Galhardo*, James Marks, Sezen Meydan*. -
Peptidic Tryptophan Halogenation by a Promiscuous Flavin-Dependent Enzyme. Angewandte Chemie International Edition.
Andrew Rice*, Mayuresh Gadgil* (University of Illinois Urbana-Champaign), Paola Bisignano, Richard Stein, Hassane Mchaourab, Douglas Mitchell*.
Featured as a “Hot Topic: Biocatalysis” paper by ChemCatChem: The European Society Journal for Catalysis. -
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site. Proceedings of the National Academies of Science of the United States of America.
Christopher Williams* (Scripps Research), Paola Munoz-Tello, Douglas Kojetin*.
Center for Structural Biology: Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics -
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis. Nature Communications.
Jeremy Williams* (University of California, San Francisco), Roman Camarda* (University of California, San Francisco), Lisa Zimmerman, Suzanne Manning, Melinda Sanders, Daniel Liebler.
NBC News: Study reveals how fat cells can fuel cancer tumors
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Department of Cell and Developmental Biology |
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3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer. Communications Biology.
Sarah Harmych*, Thomas Hasaka, Chelsie Sievers, Seung Woo Kang, Marisol Ramirez, Vivian Truong Jones, Zhiguo Zhao, Oleg Kovtun, Claudia Wahoski, Qi Liu, Ken Lau, Robert Coffey, Joshua Bauer, Bhuminder Singh*. -
Control of stress-activated Cdc42 dynamics by the MAP kinase Sty1-NDR kinase Orb6 regulatory axis. iScience.
Laura Doyle* (University of Miami Miller School of Medicine), Jun-Song Chen, Kathleen Gould. - Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment. Neuro-Oncology.
Shoaib Ajaib* (University of Leeds), Asa Brockman, Rebecca Ihrie. -
High-Specificity and Sensitivity Imaging of Neutral Lipids Using Salt-Enhanced MALDI TIMS. Journal of the American Society for Mass Spectrometry.
Kameron Molloy*, Martin Dufresne, Madeline Colley, Lukasz Migas, Raf Van de Plas, Jeffrey Spraggins*.
Supported by the Mass Spectrometry Research Center and the Molecular Design and Synthesis Center.
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Department of Molecular Physiology and Biophysics |
- What’s so hard about RNA-targeting drug discovery? Nature Computational Science.
Carlos Oliver*. -
Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk. Advanced Science.
Rui Chen*, Quan Wang, Qiang Wei, Hai Yang, James Sutcliffe, Yi Jiang, Ying Ji, Nancy Cox, Xue Zhong, Bingshan Li*. -
TrueProbes: Quantitative Single-Molecule RNA-FISH Probe Design Improves RNA Detection (preprint). bioRxiv.
Jason Hughes*, Benjamin Kesler, John Adams, Blythe Hospelhorn, Gregor Neuert*.
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Department of Pharmacology |
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Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer. JCI Insight.
Amanda Hesterberg*, Hong Yuen Wong*, Jorgen Jackson, Monika Antunovic, Brenda Rios, Evan Watkins, Riley Bergman, Brad Davidson, Sarah Ginther, Diana Graves, Elliott Nahmias, Jared Googel, Lillian Martin, Violeta Sanchez, Paula Gonzalez-Ericsson, Quanhu Sheng, Benjamin Brown, Jens Meiler, Kerry Schaffer, Jennifer Gordetsky, Ben Park, Paula Hurley*. -
Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast Cancer. Annals of Biomedical Engineering.
Sydney Henriques*, Evan Glass*, Kristen Hoek, Ori Chalom, Abigail Manning, Sohini Roy, Diana Graves, Sarah Goldstein, Benjamin Hacker, Renjie Jin, Marjan Rafat, Paula Hurley, Laura Kennedy, Young Kim, Andrew Wilson, Fiona Yull, Todd Giorgio*. -
Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors. Frontiers in Oncology.
Jinming Yang*, Weifeng Luo*, Patricia Ward, Sheau-Chiann Chen, John Zebala, Dean Maeda, Chi Yan, Ann Richmond*. - Microvascular Function and Ambulatory Capacity in Peripheral Artery Disease.
Alexander Sullivan*, Adam Behroozian* (Scripps Clinic), Crystal Coolbaugh, Emily Shardelow, Emily Smith, Quinn Wells, Daniel Clair, Aaron Aday, C Louis Garrard, John Curci, Joey Barnett, Matthew Freiberg, Rachelle Crescenzi, Manus Donahue*.
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Other basic biomedical papers |
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter.
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Vanderbilt University School of Medicine Basic Sciences
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