The Reading List - Vanderbilt School of Medicine Basic Sciences

The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.

Department of Biochemistry

Inverted chimeric RNAi molecules synergistically co-target MYC and KRAS in KRAS-driven cancers. Journal of Clinical Investigation.
Yogitha Chareddy* (University of North Carolina at Chapel Hill), Martin Egli.
LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome. Molecular Neurodegeneration.
Michael Maloney* (Denali Therapeutics Inc), Xiang Wang* (Denali Therapeutics Inc), Richard Caprioli, Michelle Reyzer.
- Supported by the Mass Spectrometry Research Center.

Department of Cell and Developmental Biology

Virtual staining of label-free tissue in imaging mass spectrometry. Science Advances.
Yijie Zhang* (University of California, Los Angeles), Luzhe Huang* (University of California, Los Angeles), Lukasz Migas, Raf Van de Plas, Jeffrey Spraggins.
Connecting chemical structure to single cell signaling profiles. Communications Biology.
Hannah Thirman*, Laura Geben, Rebecca Ihrie, Jonathan Irish*.

Department of Molecular Physiology and Biophysics

The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-Cell Identity. Diabetes.
Tanya Pierre* (University of Alabama at Birmingham), Jin-Hua Liu, Min Guo, Roland Stein.
Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions. Nature Communications.
Tianqi Wu*, Richard Stein, Te-Yu Kao, Benjamin Brown, Hassane Mchaourab*.
NF-κB inactivation in myeloid cell leads to reprogramming of whole-body energy metabolism in response to high-fat diet. Cell Death Discovery.
Xianghong Wang* (Zhuhai Clinical Medical College of Jinan University), Owen McGuinness.
Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks. Journal of Cell Biology.
Bing Han* (University of Virginia), Sarah Connolly* (University of Michigan), Alican Gulsevin, Jens Meiler, Erkan Karakas.

Department of Pharmacology

Cryo-EM reveals an extrahelical allosteric binding site at the M₅ mAChR. Nature Communications.
Wessel Burger* (Monash University), Jesse Mobbs* (Monash University), Bhavika Rana* (Monash University), Jinan Wang* (University of North Carolina, Chapel Hill), Aaron Bender, Craig Lindsley.
Sialic Acid Identity Modulates Host Tropism of Sialoglycan-binding Viridans Group Streptococci. Journal of Biological Chemistry.
KeAndreya Morrison* (Meharry Medical College), Haley Stubbs, Tina Iverson*.
Arrestins as Possible Drug Targets. Biomolecules & Therapeutics.
Zeynep Cinviz* (Istanbul Medipol University), Vsevolod Gurevich*.

First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.

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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
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Phone: (615) 322-0907 | basicsciences@vanderbilt.edu

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