Welcome to this month's edition of the Center for Health Decision Science (CHDS) newsletter. Explore recent decision science publications, upcoming seminars, and news within the field.

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The Generalized Risk-Adjusted Cost-Effectiveness (GRACE) framework is a new approach to cost-effectiveness analysis (CEA) that addresses issues related to understanding patient priorities and variation in values given differences in baseline health. Darius Lakdawalla presented this framework at a recent CHDS seminar.

CHDS faculty Jagpreet Chhatwal and colleagues evaluated the effect of multicancer early detection (MCED) tests – commonly known as liquid biopsy — for fourteen solid tumor cancer types and found that adoption of MCED testing could significantly reduce the frequency of late-stage cancer diagnoses.

Boshen Jiao, former postdoctoral fellow in the Department of Global Health and Population, CHDS faculty Stéphane Verguet, and colleagues recently published a study in PLOS Medicine that shows that childhood vaccines can prevent millions of families in low- and middle-income countries from falling into medical poverty.

This study reveals substantial engagement in disordered weight control behaviors among young people in Canada, contributing to a considerable burden of eating disorders, especially among women.

This study introduces a new metric that evaluates efficiency-equity trade-offs when the threshold inequality aversion parameter (TIAP) values are unknown.

Caro J, Chhatwal J, Fleurence RL. Health Economics and Outcomes Research in the New Era of Artificial Intelligence: Catch Me If You Can. Value Health. 2025 Nov;28(11):1626-1627.

Chhatwal J, Xiao J, ElHabr AK et al. The Impact of Multicancer Early Detection Tests on Cancer Stage Shift: A 10-Year Microsimulation Model. Cancer. 2025 Nov 15;131(22):e70075.

Coots M, Saghafian S, Kent DM et al. A Framework for Considering the Value of Race and Ethnicity in Estimating Disease Risk. Ann Intern Med. 2025 Nov 18;178(11):1676.

Dankwa EA, Cavalli L, Balasubramanian R et al. Calibration of Transmission-Dynamic Infectious Disease Models: A Scoping Review and Reporting Framework. PLoS Comput Biol. 2025 Nov 4;21(11):e1013647.

Doan TT, Wright DR, DeJonckheere M et al. Physician Preferences for Universal Routine Depression Screening for Adolescents in Primary Care. JAMA Netw Open. 2025 Nov 25;8(11):e2545361.

Fleurence RL, Dawoud D, Bian J et al. ELEVATE-GenAI: Reporting Guidelines for the Use of Large Language Models in Health Economics and Outcomes Research: An ISPOR Working Group Report. Value Health. 2025 Nov; 28(11):1611-1625. Review.

Fleurence RL, Wang X, Bian J et al. A Taxonomy of Generative Artificial Intelligence in Health Economics and Outcomes Research: An ISPOR Working Group Report. Value Health. 2025 Nov;28(11):1601-1610.

Harberger AC, Zerbe RO, Jenkins GP et al. Letter from Former SBCA Presidents and JBCA Editors to OIRA Administrator. Journal of Benefit-Cost Analysis. Published online 2025 Nov 27:1-7.

Jiao B, Sato R, Mak J et al. Financial Risk Protection from Vaccines in 52 Gavi-Eligible Low- and Middle-Income Countries: A Modeling Study. PLoS Med. 2025 Nov 4;22(11):e1004764.

Menzies NA, Brown TS, Imai-Eaton JW et al. Potential Paediatric Tuberculosis Incidence and Deaths Resulting from Interruption in Programmes Supported by International Health Aid, 2025-34: A Mathematical Modelling Study. 2025 Nov;9(11):787-795.

Shen Y, Sommers BD, Hatfield LA et al. Insurance Dynamics During Childhood in the Fragmented US Health System. JAMA. 2025 Nov 4;334(17):1533-1540.