|
|
|
3i Initiative Weekly Updates
Welcome to the 3i Weekly Update, your source for 3i relevant news and events. Please send all items of interest to Nicole.Frank@hsc.utah.edu by the end of the day on Thursdays.
| |
|
|
4/16- 4/23- FRIDAY, APRIL 16, 12-1PM -
Microbiology and Immunology Seminar - Dr. Noah Palm - Mapping Uncharted Landscapes of Host-Microbiota Connectivity
- MONDAY, APRIL 19, 2-3PM - Rising Stars in Cell Biology Seminar Series - Dr. Cornelius Taabazuing - Proteolytic Regulation of Pyroptosis
- MONDAY, APRIL 19, 4-5PM - Pharmaceutics & Pharmaceutical Chemistry Seminars - James Christie, Senior Scientist, AstraZeneca: “Antibody-Based Drug Delivery: “Synergizing Biology and Chemistry to Target Disease-Specific Therapies”
- TUESDAY, APRIL 20, 2021, 4 – 5PM -GCSC Seminar: Jessica Grindstaff, Founder, Director, Playwright and Set Designer, Phantom Limb Company “Storytelling, Imagism and Empathy: Awakening an Audience” in partnership w/UtahPresents
- WEDNESDAY, APRIL 21, 2021, 2 – 3PM - Biomedical Engineering Colloquium: Dr. Susan Bock - “Broadly Protective Flu Vaccines”
- FRIDAY, APRIL 23, 2021, 10 – 11:30AM - Biomedical Engineering Seminar - Dr. Hugh Herr - On the Design of Bionic Leg Devices: The Science of Tissue-Synthetic Interface
- THURSDAY, APRIL 22 – SATURDAY, APRIL 24, 2021 - 2021 ACCESS Research Symposium
- FRIDAY, APRIL 23, 2021, 12 – 2PM - Biomedical Engineering Seminar - Dr. Dan Ruderman - Meshing quantitative skills with biological curiosity: biomedicine’s new era
- FRIDAY, APRIL 23, 2021, 5:30 – 8:30PM - Biomedical Engineering Undergraduate Research Symposium
- MONDAY, APRIL 26, 2021, 12 – 1PM - SBS Seminar Series and LGBTQ+ STEM Interest Group Present: Malin Ah-King, Stockholm University - “At the intersection of biology/gender studies: questioning biological assumptions about sex and sexuality”
- WEDNESDAY, APRIL 28, 2021, 4 – 5PM - The H.A. and Edna Benning Medical Society and University of Utah Health invite you to a special virtual lecture: The Viruses of Our Lives: Pandemics Past, Present, and Future with 2020 MacArthur Fellow
Nels Elde, PhD
| |
|
- 3i Initiative Spring 2021 Symposium - FRIDAY, ARPIL 30, 2021, 8:00 AM -5:00 PM
- Annual Symposium: Sex, Gender and Women’s Health Across the Lifespan - THURSDAY, MAY 13, 2021
- 2021 COVID-19 Symposium - FRIDAY, JUNE 4, 2021, 8:00 AM -5:00 PM
| |
|
|
- CCTS Peer Grant Review Program - Now Accepting Research Proposals for Pre-Submission Peer Review - The Utah Center for Clinical and Translational Science (CCTS) is now accepting research proposals for pre-submission peer review. The program accepts proposals from investigators conducting research at any point along the translational science spectrum aiming to improve the health of individuals and the public. Please limit one proposal submission per investigator to the PGR. NIH review criteria will be used to score each submission. Formal reviews will be returned to the investigator by May 3, 2021. Submission Requirements Investigators are required, via email, to submit a) the completed CCTS Peer Grant Review Face Page form (see below or fillable version); b) their NIH Biographical Sketch, Specific Aims, Research Strategy, and Bibliography & References Cited as word documents; and c) any other appropriate ancillary documents as a single PDF (see Guidance Checklists) to Breanne Johnson (Breanne.Johnson@hsc.utah.edu) no later than 4:00 pm on Thursday, April 23rd, 2021.
- Hatch Scholar for T1D Research - Request for Applications - due April 30, 2021 - We are pleased to announce the sixth annual Hatch Family Scholar Award Competition for graduate students and postdoctoral fellows at the University of Utah. The purpose of this award is to honor the Hatch family by rewarding a junior research scientist that is conducting research in the field of Type 1 Diabetes. A minimum prize of $1,000 will be awarded. Prizes are subject to federal tax regulations. Applications and all supporting documents should be compiled as one PDF and submitted electronically through the University of Utah’s Competition Space interface at http://utah.infoready4.com/ by April 30, 2021 at 5pm, search “The Paul Shurtleff Hatch and Heidi Hatch Ford Scholar Award for Type 1 Diabetes Research.” See attached RFA for more details
- Call for applications: Neuro-Immunology Training Grant (NITG) - Deadline to apply 5/17 - We are pleased to announce a request for applications to fill two pre-doctoral positions on the Neuro-Immunology Training Grant (NITG). We invite applications from pre-doctoral students who have completed their departmental preliminary exam, entering at least their 3rd year in the PhD program, and are US citizens, non-citizen nationals or permanent residents. Applications from across campus will be considered from pre-doctoral graduate students working towards their PhD and engaging in any aspect of Neuro-Immunology research. Applications should be sent to Alysha Stanton (alysha.stanton@path.utah.edu) and are due on May 17th 2021 (details and instructions are attached). For questions regarding eligibility please contact the NITG directors, Dr. Ryan O’Connell (ryan.oconnell@path.utah.edu) or Dr. Karen Wilcox (karen.wilcox@hsc.utah.edu). See more.
- T32 in Genomic Medicine, Call for Applications - We are soliciting applications for 1-2 Postdoctoral positions on the T32 in Genomic Medicine Training Grant. Training slots are tentatively scheduled to begin June 1. All interested parties are encouraged to apply. We are particularly interested in applications from under-represented and minority trainees. To be eligible, candidates must be either a US Citizen or a Permanent Resident. Applications must be submitted by Friday, April 30 @ 5:00 PM MST. Full submission details are listed in the attached document. If you are considering applying, please send a brief email of intent to samantha.weeks@hsc.utah.edu as soon as possible. This information is critical for us to plan the review process.
| |
|
|
3i Funding Opportunities
Current Federal and Private FOAs applicable to the 3is can be found on the U's pivot page. New FOAs announced this week:
A monthly funding newsletter from PIVOT is sent to 3i investigators on the 2nd Monday of the month. If you have not been receiving the newsletter and would like to be added, please email Nicole.Frank@hsc.utah.edu.
| |
|
3i Investigator PublicationsCongratulations to the teams who published this week. If you have a publication that you would like included, please email us.
| |
|
CONCLUSION: The BokaFlo™ was effectively able to measure low saliva flow correlating with the PDT methodology and may provide more efficient testing of saliva flow in the dental office.
The chemical examination of two undescribed marine actinobacteria has yielded three rare merosesterterpenoids, marinoterpins A-C (1-3, respectively). These compounds were isolated from the culture broth extracts of two marine-derived actinomycetes associated with the family Streptomycetaceae, (our strains were CNQ-253 and AJS-327). The structures of the new compounds were determined by extensive interpretation of 1D and 2D NMR, MS, and combined spectroscopic data. These compounds represent new...
CONCLUSION: MDR pathogens are highly prevalent in hospital settings of Bangladesh.
No abstract
FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by altering regulatory T (T(reg)) cells. CD4^(+) T cells in patients with IPEX syndrome and Foxp3-deficient mice were analyzed by single-cell cytometry and RNA-sequencing, revealing heterogeneous T(reg)-like cells, some very similar to normal T(reg) cells, others more distant. Conventional T cells showed no widespread activation or helper T cell...
Memory consolidation is thought to occur through protein synthesis-dependent synaptic plasticity mechanisms such as long-term potentiation (LTP). Dynamic changes in gene expression and epigenetic modifications underlie the maintenance of LTP. Similar mechanisms may mediate the storage of memory. Key plasticity genes, such as the immediate early gene Arc, are induced by learning and by LTP induction. Mice that lack Arc have severe deficits in memory consolidation and Arc has been implicated in...
A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore's MinION, enable direct measurement of complex loci without introducing many of the biases inherent to short-read methods, though they suffer from relatively lower throughput. This limitation has motivated recent efforts to develop amplification-free...
The regulation of mean arterial pressure (MAP) during exercise has important physiological and clinical implications. Kinetics analysis on numerous physiological variables following the transition from unloaded-to-loaded exercise has revealed important information regarding their control. Surprisingly, the dynamic response of MAP during this transition remains to be quantified. Therefore, ten healthy participants (5/5 M/F, 24±3 years) completed repeated transitions from unloaded to moderate- and...
Nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) from HLA-identical related donors using cyclosporine (CSP) and mycophenolate mofetil (MMF) for postgrafting immunosuppression is effective therapy for hematologic cancers. However, graft-versus-host-disease (GVHD) remains a major cause of morbidity and mortality. Pilot data suggested lower acute GVHD incidence with tacrolimus/MMF compared to historical experience using CSP/MMF after nonmyeloablative HCT. In a phase II...
CONCLUSIONS: Organizations that offer primary care for persons experiencing homelessness can improve the primary care experience by tailoring the design and delivery of services.
| |
|
No abstract
CONCLUSIONS: Genotype-guided aspirin use for CRC chemoprevention may offer a cost-effective approach for the future management of average-risk individuals.
| |
|
Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like microenvironments. Toward this end, this study explored scaffold-free cell sheet technology as a new 3D platform. MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20...
Understanding factors that affect the infectivity of SARS CoV-2 is central to combatting COVID-19. The virus surface spike protein of SARS CoV-2 mediates viral entry into cells by binding to the ACE2 receptor on epithelial cells and promoting fusion. We find that Epstein-Barr virus (EBV) induces ACE2 expression when it enters the lytic replicative cycle in epithelial cells. By using VSV particles pseudotyped with the SARS CoV-2 spike protein, we show that lytic EBV replication enhances...
No abstract
CONCLUSIONS: Genotype-guided aspirin use for CRC chemoprevention may offer a cost-effective approach for the future management of average-risk individuals.
CONCLUSION: The BokaFlo™ was effectively able to measure low saliva flow correlating with the PDT methodology and may provide more efficient testing of saliva flow in the dental office.
The chemical examination of two undescribed marine actinobacteria has yielded three rare merosesterterpenoids, marinoterpins A-C (1-3, respectively). These compounds were isolated from the culture broth extracts of two marine-derived actinomycetes associated with the family Streptomycetaceae, (our strains were CNQ-253 and AJS-327). The structures of the new compounds were determined by extensive interpretation of 1D and 2D NMR, MS, and combined spectroscopic data. These compounds represent new...
CONCLUSION: MDR pathogens are highly prevalent in hospital settings of Bangladesh.
No abstract
FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by altering regulatory T (T(reg)) cells. CD4^(+) T cells in patients with IPEX syndrome and Foxp3-deficient mice were analyzed by single-cell cytometry and RNA-sequencing, revealing heterogeneous T(reg)-like cells, some very similar to normal T(reg) cells, others more distant. Conventional T cells showed no widespread activation or helper T cell...
Memory consolidation is thought to occur through protein synthesis-dependent synaptic plasticity mechanisms such as long-term potentiation (LTP). Dynamic changes in gene expression and epigenetic modifications underlie the maintenance of LTP. Similar mechanisms may mediate the storage of memory. Key plasticity genes, such as the immediate early gene Arc, are induced by learning and by LTP induction. Mice that lack Arc have severe deficits in memory consolidation and Arc has been implicated in...
| |
|
|
|
|
