Vanderbilt University | School of Medicine – Basic Science

“The Reading List” in dark teal with a drawing, in gold tones, of a person with long hair, sitting cross legged and reading a book.

The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.

Week of January 27

By Basic Sciences department

Biochemistry

Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2). Journal of Medicinal Chemistry.
Krzysztof Zak* (Boehringer Ingelheim), Alex Waterson, Jianwen Cui, Jason Phan, Jason Abbott, Dhruba Sarkar, Timothy Hodges, Allison Arnold, John Sensintaffar, Stephen Fesik.

Supported by the Biomolecular Crystallography Facility, the High-Throughput Screening Facility, and the Biomolecular NMR Facility.
Contributing factors to the oxidation-induced mutational landscape in human cells. Nature Communications.
Cameron Cordero* (University of Vermont), Kavi Mehta, Tyler Weaver* (University of Kansas Medical Center), David Cortez*.

Highlighted by Nature Communications in its Editor's Highlights: Cancer section.

Molecular Physiology and Biophysics

Comparison of Lean, Obese, and Weight Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T Cell Populations. Cancer Research.
Elysa Pierro, Matthew Cottam, Hanbing An, Brian Lehmann, Jennifer Pietenpol, Jeffrey Rathmell, Barbara Fingleton, Alyssa Hasty.

Supported by the Vanderbilt Mouse Metabolic Phenotyping Center and the Advanced Computing Center for Research and Education.
Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions. Nature Genetics.
Guochong Jia*, Zhishan Chen, Jie Ping, Qiuyin Cai, Ran Tao, Chao Li, Joshua Bauer, Tuya Pal, Sonya Reid, Bingshan Li, Xiao-Ou Shu, Xingyi Guo, Jirong Long, Wei Zheng*.

Supported by the High-Throughput Screening Facility and the Advanced Computing Center for Research and Education.

VUMC News: Study in multiancestry populations uncovers new insights into breast cancer genetics.

Pharmacology

C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway. Science.
Dawei Zhang* (Harvard Medical School), Shan Meltzer.
Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution. Alzheimer's & Dementia.
Yiyang Wu*, Julia Libby, Logan Dumitrescu, Timothy Hohman*.

VUMC News: Alzheimer’s study details abnormal gene expression tied to blood vessel growth.

First or corresponding authors are identified with a *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.

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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
Phone: (615) 322-0907 | basicsciences@vanderbilt.edu

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