The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of February 24
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School of Medicine Basic Sciences departments Biochemistry- SRBD1 facilitates chromosome segregation by promoting topoisomerase IIU+3b1 localization to mitotic chromosomes. Nature Communications.
Courtney Lovejoy*, Sarah Wessel, Rahul Bhowmick, Runxiang Zhao, David Cortez*.
- Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis. PNAS.
Kathryn Brewer*, Hui Huang, Katherine Clowes Moster, James Hayes, Dylan Burnette, Charles Sanders*.
Supported by the Cell and Developmental Biology Equipment Resource.
Basic Sciences: Vanderbilt and Northwestern labs discover new mechanisms that cause irregular heartbeat.
- VARP binds SNX27 to promote endosomal supercomplex formation on membranes. Science Advances.
Mintu Chandra*, Amy Kendall, Marijn Ford, Lauren Jackson*.
Weekly Coordinates: Greater than the sum of its parts: the role of VARP-SNX27 binding in endosomal “supercomplex” formation
Cell and Developmental Biology- Tenascin-C potentiates Wnt signaling in thyroid cancer. Endocrinology.
Heather Hartmann*, Matthew Loberg, George Xu, Anna Schwarzkopf, Sheau-Chiann Chen, Courtney Phifer, Kailey Caroland, Hua-Chang Chen, Diana Diaz, Megan Tigue, Amanda Hesterberg, Jean-Nicolas Gallant, Quanhu Sheng, James Netterville, Sarah Rohde, Carmen Solórzano, Lindsay Bischoff, Naira Baregamian, Paula Hurley, Barbara Murphy, Jennifer Choe, Fei Ye, Ethan Lee, Vivian Weiss*.
Supported by the Vanderbilt Cell Imaging Shared Resource.
- Pharmacological Inhibition of U+3b2 Myosin II Disrupts Sarcomere Assembly in Human iPSC-Derived Cardiac Myocytes. Cytoskeleton.
James Hayes,* Dylan Burnette*.
- Microvillus inclusion disease-causing MYO5B point mutations exert differential effects on motor function. Journal of Biological Chemistry.
Deanna Bowman*, Leslie Meenderink, Kyra Thomas, Elizabeth Manning, Matthew Tyska, James Goldenring*.
Molecular Physiology and Biophysics Pharmacology
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First or corresponding authors are identified with an *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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