The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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Department of Biochemistry |
Department of Cell and Developmental Biology |
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Direct comparison of constitutive Rax-Cre transgenic drivers that activate in the mouse embryonic eye field (preprint). bioRxiv.
Nadean Brown*, Samuel Goodyear-Brown, Sabine Fuhrmann*. -
Advanced Dimensionality Reduction for Imaging Mass Spectrometry of Human Eye Tissue through Low-Rank Modeling with Sparse and Dense Residuals. Analytical Chemistry.
Roger Moens* (Delft University of Technology), David Anderson, Richard Caprioli, Christine Curcio, Kevin Schey, Jeffrey Spraggins, Raf Van de Plas*.
Supported by the Mass Spectrometry Research Center. -
Matrix Metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution. Molecular Biology of the Cell.
Indrayani Waghmare* (University of Massachusetts Lowell), Patrick Page-McCaw, Andrea Page-McCaw.
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Department of Molecular Physiology and Biophysics |
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Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assay. Lab on a Chip.
Shannon Faley*, David Schaffer, Eric Spivey, John Wikswo*, Jacquelyn Brown. -
Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models. Journal of Clinical Investigation.
Elizabeth Hennen*, Sasidhar Uppuganti, Néstor de la Visitación, Wei Chen, Jaya Krishnan, Lawrence Vecchi, David Patrick, Rachel Delgado, Mark de Caestecker, Rachelle Johnson, David Harrison*, Jeffry Nyman*. -
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk. Cancer Medicine.
Tianying Zhao*, Jiajun Shi, Dan Zhou, Jie Ping, Shuai Xu, Lili Xu, Jie Wu, Xiao-Ou Shu, Ran Tao, Bingshan Li, Wei Zheng, Jirong Long, Qiuyin Cai*.
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Department of Pharmacology |
- A generalizable deep learning framework for structure-based protein-ligand affinity ranking. Proceedings of the National Academy of Sciences.
Benjamin Brown*.
Supported by the Center for AI in Protein Dynamics and the Center for Structural Biology.
School of Medicine Basic Sciences: Vanderbilt scientist tackles key roadblock for AI in drug discovery -
Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors. Frontiers in Oncology.
Jinming Yang*, Weifeng Luo*, Patricia Ward, Sheau-Chiann Chen, Chi Yan*, Ann Richmond*.
School of Medicine Basic Sciences: Promising new drug combination may help melanoma patients resistant to treatment respond once again to the body’s immune defenses - Kappa opioid receptor control of motivated behavior revisited. Neuropsychopharmacology.
Zahra Farahbakhsh*, Cody Siciliano*. -
Muscarinic Acetylcholine Receptor Activators as Transformative Therapeutics for Schizophrenia. Annual Review of Medicine.
P. Jeff Conn*. -
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391). Journal of Medicinal Chemistry.
Motoyuki Tanaka* (Ono Pharmaceutical), Elizabeth Childress, Sean Bollinger, Joza Schmitt, Trevor Chopko, Aaron Garrison, Charles Perry, Keagan Chronister, Meghan Kramer, Sichen Chang, Katherine Watson, Jonathan Dickerson, Michael Bubser, Jerri Rook, Carrie Jones, Olivier Boutaud, Thomas Bridges, Jerod Denton, Darren Engers, Craig Lindsley*. -
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand. ACS Chemical Biology.
Belinda Hetzler* (New York University), Prashant Donthamsetti*.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
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