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Amphibians offer clues to climate change resiliency
Like the “canary in the coal mine,” the worldwide decline of amphibian populations, including frogs, toads and salamanders, during the past 50 years may be a harbinger of emerging infections and environmental changes that endanger humankind, as well.
Just as important, some amphibian species have begun to recover from the global spread of a fungal infection called chytridiomycosis that caused the extinction of others. Their resilience suggests that our slimy friends may hold a secret to survival. Louise Rollins-Smith, PhD, is a professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center who studies the immune defense mechanisms of amphibians...
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VUMC researchers a step closer to broad ebolavirus protection
A combination of two broadly acting monoclonal antibodies isolated by researchers at Vanderbilt University Medical Center protected non-human primates from ebolavirus disease, which causes severe and often-fatal hemorrhagic fever in humans.
Their findings, published this week in the journal Cell, bring closer to development the first clinical therapy effective against all three primary ebolaviruses responsible for repeated outbreaks of the disease in equatorial Africa.
“The infectious diseases community has long wanted a single antibody combination to deal with all of the various strains of ebolaviruses, and now we have finally identified a promising combination that fits the bill,” said James Crowe Jr., MD, director of the Vanderbilt Vaccine Center...
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Molecular imaging of C. diff infectionDisruption of the gut microbiota, for example by antibiotics, allows the bacterium Clostridioides difficile (C. diff) to colonize and cause disease. C. diff is the leading cause of hospital-associated intestinal infections in the U.S., but the mechanisms of colonization are unclear.
Eric Skaar, PhD, Jeffrey Spraggins, PhD, and colleagues used imaging mass spectrometry, a molecular imaging technique, to explore how C. diff impacts the gut environment in an animal model of infection...
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The Division Congratulations to participating faculty who contributed to 23 publications, posted on PubMed last month!
Business Meeting &Chalk Talk November 30th
Sebastian Joyce
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Subscribe to their newsletter for personalized job postings in your field.
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| Mondays at Noon - See the PMI calendar for location information.
- November 1 - Ali Ellebedy, PhD
Associate Professor, Pathology & Immunology
Washington University in St. Louis
- November 8 - Ryan O’Connell, PhD
Professor of Pathology
University of Utah
- November 15 - Deborah Hung, MD, PhD
Professor of Genetics, Medicine, and Molecular Biology
Broad Institute
- November 22 - No Seminar (Thanksgiving)
Professor of Molecular Immunology and Pathology
New York University
- November 29 - Leah Cowen, PhD
Professor of Molecular Genetics
University of Toronto
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| Tuesdays at 10:30 am - Stay tuned to the VI4 newsletter for locations.
- November 2 - Lev Becker, PhD
Associate Professor, Ben May Department for Cancer Research
University of Chicago - November 16 - Gianna Hammer, PhD
Assistant Professor, Immunology
Duke University
- November 30 - Matthias Gunzer, PhD
Professor, Biospectroscopy
University of Duisburg-Essen
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MHI
Journal Club
Meeting November 3rd & 17th at 9 amin MCN A5221!
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Wednesdays at 1:00 pm on Zoom
- November 3 - Heather Pua
- November 10 - Sarika Saraswati
- November 17 - Deb Lannigan
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| Thursdays at 1:00 pm in 1220 MRBIII
- November 4 - OPEN
- November 11 - Caitlin Murdoch (Skaar Lab)
- November 18 - Jamisha Francis & Laura Hesse (Gaddy & Drake Labs)
- November 25 - No Meeting (Thanksgiving)
- December 2 - OPEN
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- November 5 - Luke Postoak (Van Kaer Lab)
- November 12 - Neil Sprenkle (Pua Lab)
- November 19 - Kelsey Pelweski (Georgiev Lab)
- November 26 - No Meeting (Thanksgiving)
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MP faculty publications: October 2021 - Sowd GA, Shi J, Aiken C
J Virol. 2021 Oct 6:JVI0144521 - Chen X, Chen DG, Zhao Z, Balko JM, Chen J
Breast Cancer Res. 2021 Oct 10;23(1):96 - Lévy R, Langlais D, Béziat V, Rapaport F, Rao G, Lazarov T, Bourgey M, Zhou YJ, Briand C, Moriya K, Ailal F, Avery DT, Markle J, Lim AI, Ogishi M, Yang R, Pelham S, Emam M, Migaud M, Deswarte C, Habib T, Saraiva LR, Moussa EA, Guennoun A, Boisson B, Belkaya S, Martinez-Barricarte R, Rosain J, Belkadi A, Breton S, Payne K, Benhsaien I, Plebani A, Lougaris V, Di Santo JP, Neven B, Abel L, Ma CS, Bousfiha AA, Marr N, Bustamante J, Liu K, Gros P, Geissmann F, Tangye SG, Casanova JL, Puel A
J Clin Invest. 2021 Sep 1;131(17):e150143 - Perlmutter JI, Meyers JE, Bordenstein SR
Elife. 2021 Oct 22;10:e67686. doi: 10.7554/eLife.67686 - Miller AK, Westlake CS, Cross KL, Leigh BA, Bordenstein SR
PLoS Biol. 2021 Oct 26;19(10):e3001417 - Shealy NG, Yoo W, Byndloss MX
Curr Opin Microbiol. 2021 Oct 20;64:82-90 - Wessel AW, Doyle MP, Engdahl TB, Rodriguez J, Crowe JE Jr, Diamond MS
mBio. 2021 Oct 26;12(5):e0244021 - Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe JE Jr
Cell. 2021 Oct 28;184(22):5593-5607.e18 - Hsieh CL, Werner AP, Leist SR, Stevens LJ, Falconer E, Goldsmith JA, Chou CW, Abiona OM, West A, Westendorf K, Muthuraman K, Fritch EJ, Dinnon KH 3rd, Schäfer A, Denison MR, Chappell JD, Baric RS, Graham BS, Corbett KS, McLellan JS
Cell Rep. 2021 Oct 16:109929 - Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I
Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6526-31 - Luo Y, Kanai M, Choi W, Li X, Sakaue S, Yamamoto K, Ogawa K, Gutierrez-Arcelus M, Gregersen PK, Stuart PE, Elder JT, Forer L, Schönherr S, Fuchsberger C, Smith AV, Fellay J, Carrington M, Haas DW, Guo X, Palmer ND, Chen YI, Rotter JI, Taylor KD, Rich SS, Correa A, Wilson JG, Kathiresan S, Cho MH, Metspalu A, Esko T, Okada Y, Han B; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, McLaren PJ, Raychaudhuri S
Nat Genet. 2021 Oct;53(10):1504-1516 - Miranda-Katz M, Erickson JJ, Lan J, Ecker A, Zhang Y, Joyce S, Williams JV
Sci Rep. 2021 Oct 21;11(1):20769 - Connelly AR, Jeong BM, Coden ME, Cao JY, Chirkova T, Rosas-Salazar C, Cephus JY, Anderson LJ, Newcomb DC, Hartert TV, Berdnikovs S
Viruses. 2021 Oct 13;13(10):2055 - Diller JR, Carter MH, Kanai Y, Sanchez SV, Kobayashi T, Ogden KM
J Infect Dis. 2021 Oct 10:jiab479 - Berumen Sánchez G, Bunn KE, Pua HH, Rafat M
Cell Commun Signal. 2021 Oct 16;19(1):104 - Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N
J Cell Mol Med. 2021 Oct 19 - Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR.
Front Immunol. 2021 Oct 12;12:757836 - McNaughton CD, Adams NM, Hirschie Johnson C, Ward MJ, Schmitz JE, Lasko TA
J Biol Rhythms. 2021 Oct 26:7487304211051841 - Angaramo S, Law JC, Maris AS, Schmitz JE, Liu Y, Chen Q, Chomsky A
BMJ Open Ophthalmol. 2021 Oct 5;6(1):e000804 - Rees AB, Schultz JD, Wollenman LC, Moore-Lotridge SN, Martus JE, Schoenecker JG, Mencio GA
J Bone Joint Surg Am. 2021 Oct 21 - Ahlers CG, Lan M, Schoenecker JG, Borst AJ
J Pediatr Hematol Oncol. 2021 Oct 15 - Polosukhina D, Singh K, Asim M, Barry DP, Allaman MM, Hardbower DM, Piazuelo MB, Washington MK, Gobert AP, Wilson KT, Coburn LA
Oncogene. 2021 Oct 8 - Liu J, Zhong J, Yang H, Wang D, Zhang Y, Yang Y, Xing G, Kon V
J Ren Nutr. 2021 Oct 16:S1051-2276(21)00219-3
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