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The Vanderbilt Institute for Infection, Immunology & Inflammation has announced VI4 Annual Symposium 2019 for April 10th. It will bring together hundreds of researchers from VU, VUMC, and Meharry Medical College, with interests in clinical and basic science, aspects of infectious disease, immunology, inflammation, and microbiology. Registration and Abstract Submission are now open. Dr. Rob Edwards' bioinformatics lab at San Diego State University is in the vanguard of developing and using computational tools to study “life’s best-kept secrets” - the genomes of the microbial and viral world in and around us. In the Department of Computer Science, he uses high-performance computer science and biology to study microbial communities in many different environments, including the human microbiome and virome. Dr. Edwards metagenomic research made a major breakthrough in identifying a highly abundant and new circular double-stranded DNA virus in over 50% of the human population. This virus, named crAssphage, is a DNA bacteriophage in Bacteroidetes that dominates the human gut microbiome from birth and onward. In addition to this groundbreaking discovery, Dr. Edwards is advancing knowledge and tools to understand the vast viral dark matter on Earth.
Dr. Edwards was invited to present at VI4 Symposium by The Vanderbilt Microbiome Initiative (VMI). We are very excited to have him! Abstract Submission deadline has been extended to March 8th (This Friday), please make sure everyone in your lab is aware that Abstract Submissions are due!
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| A new shared resource core available to you:The CIT is a state-of-the-art small molecule omics shared resource center and collaborative analytical facility specializing in a range of mass spectrometry and confocal screening techniques. The facility can measure the complex array of small molecule metabolites present within a fluid, cell, or tissue and can identify reproducible steady state and/or temporal changes associated with disease state or drug administration for context-dependent analysis.
Afterward, metabolite identifications are assigned based on high mass accuracy measurements, isotope distributions, tandem MS fragmentation patterns, and comparisons with spectral libraries and standards. Consequently, the results can reveal unique biochemical fingerprints of cellular processes specific to each sample. This can be exploited as a discovery-based approach for generating novel hypotheses or used for a better understanding of physiological processes mediated by genetic or environmental perturbations. If needed, new workflows can be established for method development, targeted biomolecule measurement acquisition, and/or metabolite validation.
We support investigators in numerous phases of the analytical pipeline and provide a number of routine and/or advanced services depending on the goals of the individual research projects.
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Division Announcements
Congratulations to participating faculty who contributed to 31 publications, posted on PubMed last month!
Tuesday March 5th:
Business Meeting
Friday March 8th:Division Happy Hour4pm, MRBIII 5th floor Atrium
Follow and engage with us on Twitter:
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- 3/4 - Justin Milner, Ph.D. Immunology Faculty Candidate
- 3/11 - No Seminar Spring Break
- 3/18 - No Seminar Spring Break
- 3/25 - TBA
- 4/1 - Alice Prince, MD Professor of Pediatrics at Columbia University
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- 3/7 - Dalton Greenwood & Jenna Petronglo - Rathmell & Cassat Labs
- 3/14 - Will Dunker & Yvonne Latour - Karijolich & Wilson Labs
- 3/21 - Aaron Wexler - Skaar Lab
- 3/28 - Neil Sprenkle & Cara Lang - Pua & Kim Labs
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- 3/1 - Amy Major, Ph.D. - PI
- 3/8 - Guan Yang, Ph.D. - Van Kaer Lab
- 3/15 - Dalton Greenwood - Rathmell Lab
- 3/22 - Holly Algood, Ph.D. - PI
- 3/29 - Cody Strothers - Sherwood Lab
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- 3/12 - I-Cheng Ho, MD, Ph.D. - Harvard Medical School
- 3/26 - Catherine Blish, MD, Ph.D. - Stanford University
- 4/23 - Coleen McNamara, MD - University of Virginia School of Medicine
- 5/14 - Andy Minn, MD, Ph.D. - University of Pennsylvania
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- 3/7 - Tyler Reese, M.D. - Vanderbilt University
- 3/14 - Sallaya Chinratanalab, M.D. and Paul Wheeler, M.D. - Vanderbilt University and Saint Thomas
- 3/21 - Robert Lentz, M.D. - Vanderbilt University
- 3/28 - Anna K. Dewan, M.D. - Vanderbilt University
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MP faculty publications: February - Fetal Membrane Organ-On-Chip: An Innovative Approach to Study Cellular Interactions. Richardson L, Gnecco J, Ding T, Osteen K, Rogers LM, Aronoff DM, Menon R
Reprod Sci. 2019 Feb 21;:1933719119828084 - Evaluation of procalcitonin immunoassay concordance near clinical decision points. Chambliss AB, Hayden J, Colby JM
Clin Chem Lab Med. 2019 Feb 14;: - Incidence and malignancy rates of indeterminate pediatric thyroid nodules. Wang H, Mehrad M, Ely KA, Liang J, Solórzano CC, Neblett WW, Coogan AC, Weiss VL
Cancer Cytopathol. 2019 Feb 15;: - Posttraumatic Stress Symptoms Mediate the Effects of Trauma Exposure on Clinical Indicators of Central Sensitization in Patients With Chronic Pain. McKernan LC, Johnson BN, Crofford LJ
Clin J Pain. 2019 Feb 05;: - Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE, Wilson IA, Ward AB
PLoS Biol. 2019 Feb 04;17(2):e3000139 - Antibody Determinants of Influenza Immunity. Crowe JE
J Infect Dis. 2019 Jan 31;: - Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice. Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE, Screaton GR, Diamond MS
Cell Rep. 2019 Feb 05;26(6):1585-1597.e4 - New-onset post-transplant diabetes mellitus after allogeneic hematopoietic cell transplant is initiated by insulin resistance, not immunosuppressive medications. Engelhardt BG, Savani U, Jung DK, Powers AC, Jagasia M, Chen H, Winnick JJ, Tamboli RA, Crowe JE, Abumrad NN
Biol Blood Marrow Transplant. 2019 Feb 06;: - High frequency of shared clonotypes in human B cell receptor repertoires. Soto C, Bombardi RG, Branchizio A, Kose N, Matta P, Sevy AM, Sinkovits RS, Gilchuk P, Finn JA, Crowe JE
Nature. 2019 Feb 13;: - Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, et al
Nat Immunol. 2019 Feb 11;: - HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms. Konvinse KC, Trubiano JA, Pavlos R, James I, Shaffer CM, Bejan CA, Schutte RJ, Ostrov DA, Pilkinton MA, Rosenbach M, Zwerner JP, Williams KB, Bourke J, Martinez P, Rwandamuriye F, Chopra A, Watson M, Redwood AJ, White KD, Mallal SA, Phillips EJ
J Allergy Clin Immunol. 2019 Feb 15;: - Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium. Gnecco JS, Ding T, Smith C, Lu J, Bruner-Tran KL, Osteen KG
Hum Reprod. 2019 Feb 21;: - α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY. Sierra JC, Suarez G, Piazuelo MB, Luis PB, Baker DR, Romero-Gallo J, Barry DP, Schneider C, Morgan DR, Peek RM Jr, Wilson KT
Proc Natl Acad Sci U S A. 2019 Feb 25. - Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking. Martin H C, Ibáñez R, Nothias LF, Boya P CA, Reinert LK, Rollins-Smith LA, Dorrestein PC, Gutiérrez M
Sci Rep. 2019 Feb 28;9(1):3019 - Effects of Antibiotic Timing on Culture Results and Clinical Outcomes in Pediatric Musculoskeletal Infection. Benvenuti MA, An TJ, Mignemi ME, Martus JE, Thomsen IP, Schoenecker JG
J Pediatr Orthop. 2019 Mar;39(3):158-162 - A Clinical Prediction Algorithm to Stratify Pediatric Musculoskeletal Infection by Severity. Benvenuti MA, An TJ, Mignemi ME, Martus JE, Mencio GA, Lovejoy SA, Schoenecker JG, Williams DJ
J Pediatr Orthop. 2019 Mar;39(3):153-157 - Tranexamic acid is an active site inhibitor of urokinase plasminogen activator. Wu G, Mazzitelli BA, Quek AJ, Veldman MJ, Conroy PJ, Caradoc-Davies TT, Ooms LM, Tuck KL, Schoenecker JG, Whisstock JC, Law RHP
Blood Adv. 2019 Mar 12;3(5):729-733 - Regulation of leukocyte function by citric acid cycle intermediates. Patil NK, Bohannon JK, Hernandez A, Patil TK, , Sherwood ER
J Leukoc Biol. 2019 Feb 21;: - S100 Proteins in the Innate Immune Response to Pathogens. Kozlyuk N, Monteith AJ, Garcia V, Damo SM, Skaar EP, Chazin WJ
Methods Mol Biol. 2019;1929:275-290 - An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration. Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP
Cell Rep. 2019 Feb 19;26(8):2009-2018.e6 - PheWAS uncovers a pathological role of coagulation Factor X during Acinetobacter baumannii infection. Choby JE, Monteith AJ, Himmel LE, Margaritis P, Shirey-Rice JK, Pruijssers A, Jerome RN, Pulley J, , Skaar EP
Infect Immun. 2019 Feb 19;: - Assessing Acinetobacter baumannii Virulence and Persistence in a Murine Model of Lung Infection. Palmer LD, Green ER, Sheldon JR, Skaar EP
Methods Mol Biol. 2019;1946:289-305 - Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic Escherichia coli. Palmer LD, Skaar EP
MBio. 2019 Feb 26;10(1): - Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus. Grunenwald CM, Choby JE, Juttukonda LJ, Beavers WN, Weiss A, Torres VJ, Skaar EP
MBio. 2019 Feb 26;10(1): - Correction: ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors. Guerrero-Zotano AL, Stricker TP, Formisano L, Hutchinson KE, Stover DG, Lee KM, Schwarz LJ, Giltnane JM, Estrada MV, Jansen VM, Servetto A, Gavilá J, Perez-Fidalgo JA, Lluch A, Llombart-Cussac A, Bayar MA, Michiels S, André F, Arnedos M, Guillem V, Ruiz-Simon A, Arteaga CL
Clin Cancer Res. 2019 Feb 15;25(4):1431 - Correction: Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer. Hanker AB, Estrada MV, Bianchini G, Moore PD, Zhao J, Cheng F, Koch JP, Gianni L, Tyson DR, Sánchez V, Rexer BN, Sanders ME, Zhao Z, Stricker TP, Arteaga CL
Cancer Res. 2019 Feb 15;79(4):873 - iNKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice. Park HJ, Lee SW, Im W, Kim M, Van Kaer L, Hong S
Mediators Inflamm. 2019;2019:3540974 - Bronchoalveolar Fluid and Plasma Inflammatory Biomarkers in Contemporary ARDS Patients. Stapleton RD, Suratt BT, Neff MJ, Wurfel MM, Ware LB, Ruzinski JT, Caldwell E, Hallstrand TS, Parsons PE
Biomarkers. 2019 Feb 12;:1-25 - Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT
Oncogene. 2019 Feb;38(7): - Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease. Scoville EA, Allaman MM, Adams DW, Motley AK, Peyton SC, Ferguson SL, Horst SN, Williams CS, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA
Sci Rep. 2019 Feb 27;9(1):2882 - Modulation of cell adhesion and migration through regulation of the immunoglobulin superfamily member ALCAM/CD166. von Lersner A, Droesen L, Zijlstra A
Clin Exp Metastasis. 2019 Feb 18;:
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