MP faculty publications: February 2024

1. TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer

   Lynce F, Stevens LE, Li Z, Brock JE, Gulvady A, Huang Y, Nakhlis F, Patel A, Force JM, Haddad TC, Ueno N, Stearns V, Wolff AC, Clark AS, Bellon JR, Richardson ET, Balko JM, Krop IE, Winer EP, Lange P, Hwang ES, King TA, Tolaney SM, Thompson A, Gupta GP, Mittendorf EA, Regan MM, Overmoyer B, Polyak K.
   Breast Cancer Res. 2024 Jan 31;26(1):20.

2. Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance

   James JL, Taylor BC, Axelrod ML, Sun X, Guerin LN, Gonzalez-Ericsson PI, Wang Y, Sanchez V, Fahey CC, Sanders ME, Xu Y, Hodges E, Johnson DB, Balko JM.
   J Immunother Cancer. 2023 Nov 20;11(11):e007736

3. A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury

   Kuhar E, Chander N, Stewart DJ, Jahandideh F, Zhang H, Kristof AS, Bastarache JA, Schmidt EP, Taljaard M, Thébaud B, Engelberts D, Fergusson DA, Lalu MM.
   Am J Physiol Lung Cell Mol Physiol. 2024 Feb 13.

4. LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation

   Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT
   Cardiovasc Res. 2024 Feb 20:cvae036.

5. A fungal metabolic regulator underlies infectious synergism during Candida albicans - Staphylococcus aureus intra-abdominal co-infection.

   Paul S, Todd OA, Eichelberger KR, Tkaczyk C, Sellman BR, Noverr MC, Cassat JE, Fidel PL, Peters BM.
   bioRxiv [Preprint]. 2024 Feb 15:2024.02.15.580531.

6. The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk

   Tran SC, Bryant KN, Cover TL
   Gut Microbes. 2024 Jan-Dec;16(1):2314201.

7. Mapping niche-specific two-component system requirements in uropathogenic Escherichia coli

   Brannon JR, Reasoner SA, Bermudez TA, Comer SL, Wiebe MA, Dunigan TL, Beebout CJ, Ross T, Bamidele A, Hadjifrangiskou M.
   Microbiol Spectr. 2024 Feb 22:e0223623.

8. Federal Oversight of Laboratory-Developed Tests

   Pierce VM, Humphries RM.
   N Engl J Med. 2024 Feb 1;390(5):482-483.

9. A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists

   Baljon JJ, Kwiatkowski AJ, Pagendarm HM, Stone PT, Kumar A, Bharti V, Schulman JA, Becker KW, Roth EW, Christov PP, Joyce S, Wilson JT.
   ACS Nano. 2024 Feb 22.

10. Immunophenotypic predictors of influenza vaccine immunogenicity in pediatric hematopoietic cell transplant recipients

    Amarin JZ, Dulek DE, Simmons J, Hayek H, Chappell JD, Nochowicz CH, Kitko CL, Schuster JE, Muñoz FM, Bocchini CE, Moulton EA, Coffin SE, Freedman JL, Ardura MI, Wattier RL, Maron G, Grimley M, Paulsen G, Danziger-Isakov L, Carpenter PA, Englund JA, Halasa NB, Spieker AJ, Kalams SA.
    Blood Adv. 2024 Feb 22:bloodadvances.2023012118

11. Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis

    Gibson A, Ram R, Gangula R, Li Y, Mukherjee E, Palubinsky AM, Campbell CN, Thorne M, Konvinse KC, Choshi P, Deshpande P, Pedretti S, O'Neil RT, Wanjalla CN, Kalams SA, Gaudieri S, Lehloenya RJ, Bailin SS, Chopra A, Trubiano JA, Peter JG, Mallal SA, Phillips EJ.
    bioRxiv [Preprint]. 2024 Feb 18:2023.11.26.568771.

12. Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA

    Ye X, Guerin LN, Chen Z, Rajendren S, Dunker W, Zhao Y, Zhang R, Hodges E, Karijolich J.
    Cell Rep. 2024 Feb 27;43(3):113888.

13. PINK1 is a target of T cell responses in Parkinson's disease

    Williams GP, Michaelis T, Lima-Junior JR, Frazier A, Tran NK, Phillips EJ, Mallal SA, Litvan I, Goldman JG, Alcalay RN, Sidney J, Sulzer D, Sette A, Lindestam Arlehamn CS.
    bioRxiv [Preprint]. 2024 Feb 12:2024.02.09.579465.

14. Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis

    Jacobse J, Pilat JM, Li J, Brown RE, Kwag A, Buendia MA, Choksi YA, Washington MK, Williams CS, Markham NO, Short SP, Goettel JA.
    Front Oncol. 2024 Feb 5;13:1276743.

15. Characterizing the Journey of Geographic Atrophy Patients in Routine Ophthalmic Practice

    Gupta U, Maatouk CM, Markle JC, Talcott KE, Singh RP, Rachitskaya AV.
    Ophthalmic Surg Lasers Imaging Retina. 2024 Feb 1:1-7

16. Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency

    Duke S, Maiarana J, Yousefi P, Burks E, Gerrie S, Setiadi A; BC Children's and St Paul's Hospital Members; Hildebrand KJ, James E, Turvey SE,Markle JG, Biggs CM
    Pediatr Allergy Immunol. 2024 Feb;35(2):e14077.

17. Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome

    Gutor SS, Salinas RI, Nichols DS, Bazzano JMR, Han W, Gokey JJ, Vasiukov G, West JD, Newcomb DC, Dikalova AE, Richmond BW, Dikalov SI, Blackwell TS, Polosukhin VV.
    Am J Physiol Lung Cell Mol Physiol. 2024 Feb 27.

18. Ion Transport Basis of Diarrhea, Paneth Cell Metaplasia, and Upregulation of Mechanosensory Pathway in Anti-CD40 Colitis Mice

    Jayawardena D, Anbazhagan AN, Majumder A, Akram R, Nazmi A, Kaur R, Kumar A, Saksena S, Olivares-Villagómez D, Dudeja PK
    Inflamm Bowel Dis. 2024 Feb 1:izae002.

19. De novo variants in DENND5B cause a neurodevelopmental disorder

    Scala M, Tomati V, Ferla M, Lena M, Cohen JS, Fatemi A, Brokamp E, Bican A, Phillips JA 3rd, Koziura ME, Nicouleau M, Rio M, Siquier K, Boddaert N, Musante I, Tamburro S, Baldassari S, Iacomino M, Scudieri P; Undiagnosed Diseases Network; Rosenfeld JA, Bellus G, Reed S, Al Saif H, Russo RS, Walsh MB, Cantagrel V, Crunk A, Gustincich S, Ruggiero SM, Fitzgerald MP, Helbig I, Striano P, Severino M, Salpietro V, Pedemonte N, Zara F.
    Am J Hum Genet. 2024 Feb 16:S0002-9297(24)00033-8.

20. EFEMP1 haploinsufficiency causes a Marfan-like hereditary connective tissue disorder

    Forghani I, Lang SH, Rodier MJ, Bivona SA; Undiagnosed Diseases Network (Phillips JA 3rd); Morales AA, Zuchner S, Bademci G, Tekin M.
    Am J Med Genet A. 2024 Feb 13:e63556.

21. ATF6 protects against protein misfolding during cardiac hypertrophy

    Hofmann C, Aghajani M, D Alcock C, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S.
    J Mol Cell Cardiol. 2024 Feb 23;189:12-24.

22. The proteostasis interactomes of trafficking-deficient K V 11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue

    Egly CL, Barny L, Do T, McDonald EF, Plate L, Knollmann BC.
    bioRxiv [Preprint]. 2024 Jan 31:2024.01.31.574410

23. Sequestration and Involucrum: Understanding Bone Necrosis and Revascularization in Pediatric Orthopedics

    Hajdu KS, Baker CE, Moore-Lotridge SN, Schoenecker JG.
    Orthop Clin North Am. 2024 Apr;55(2):233-246.

24. Navigating the Enigma of Pediatric Musculoskeletal Infections: A Race Against Time

    Moore-Lotridge SN, Hou BQ, Hajdu KS, Anand M, Hefley W, Schoenecker JG.
    Orthop Clin North Am. 2024 Apr;55(2):217-232.

25. Improving Neuromuscular Monitoring Through Education-Based Interventions and Studying Its Association With Adverse Postoperative Outcomes: A Retrospective Observational Study

    Carr SG, Clifton JC, Freundlich RE, Fowler LC, Sherwood ER, McEvoy MD, Robertson A, Dunworth BA, McCarthy KY, Shotwell MS, Kertai MD.
    Anesth Analg. 2024 Mar 1;138(3):517-529.

26. A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance

    Freiberg JA, Tao L, Manuel C, Mike LA, Nelson GE, Harris BD, Mathers AJ, Talbot TR, Skaar EP, Humphries RM.
    Antimicrob Agents Chemother. 2024 Feb 20:e0150723.

27. Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord

    Schilling KG, Combes AJE, Ramadass K, Rheault F, Sweeney G, Prock L, Sriram S, Cohen-Adad J, Gore JC, Landman BA, Smith SA, O'Grady KP.
    Magn Reson Imaging. 2024 Feb 2;108:11-21.

28. Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

    Critchlow JT, Prakash A, Zhong KY, Tate AT.
    PLoS Pathog. 2024 Feb 26;20(2):e1012049.

29. Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy

    Hoogenboezem EN, Patel SS, Lo JH, Cavnar AB, Babb LM, Francini N, Gbur EF, Patil P, Colazo JM, Michell DL, Sanchez VM, McCune JT, Ma J, DeJulius CR, Lee LH, Rosch JC, Allen RM, Stokes LD, Hill JL, Vickers KC, Cook RS, Duvall CL.
    Nat Commun. 2024 Feb 21;15(1):1581.