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Published Article Featuring Ependymoma Advances

Recent Advances in the Classification and Treatment of Ependymomas

Ependymomas are rare neuroepithelial primary central nervous system (CNS) tumors that affect children and adult patients in which they make up 1.8% of all primary CNS tumors. In this article, authors review the classification, pathology and current clinical approaches.
Traditionally, ependymomas have been classified based on their histological appearance. However, the basis of clinical behavior of ependymal tumors is not clearly understood. Recent advances in molecular profiling have challenged the notion to rely solely on histological grading to plan treatment. It is becoming increasingly clear that age, location, as well as genetic markers play a major role in stratifying treatment and predicting survival.
The goal of this article is to outline the implications of the new WHO classification for ependymoma and review the pathology of the underlying tumor and current clinical approaches to decrease morbidity and improve survival in adult patients with ependymoma.
To read the overview of the Neuro-oncology Article, CLICK HERE.
Sofia's Family

Sofia the Warrior

By Sabrina (Sofia's mom)
CERN Inspiration Story
In December of 2016, our daughter, Sofia, slipped on the wet tile floor. After a few hours of consistent crying, we decided to take her to the ER. Doctors ordered an x-ray and determined she had a bruised coccyx (located in her lower tailbone). They recommended pain medication and rest, saying it could take up to six weeks to recover. After many sleepless nights and lots of Advil, six weeks passed and Sofia felt better. We thought she had healed. At the beginning of June, she started to complain again of pain. Her pediatrician and I assumed she re-injured her coccyx from dancing in her hip hop class. She began taking pain medication again but she only got worse. By the middle of July, we scheduled an appointment to see an orthopedic doctor. He examined her and again assumed she probably had a herniated disk. He advised us to have a six week course of physical therapy. My husband suggested doing an MRI first to rule out anything else. The doctor went along with the idea.
The Day My Heart Broke
A few days later, she went in for what they said would be a 30 minute MRI, until the radiologist decided she needed contrast (injected into the body, the contrast enhances and improves the quality of the MRI images). We were very concerned and didn't leave until speaking with the radiologist first to understand his suspicions. That was the day my heart broke and our lives were turned upside down. He stated that she had a malignant tumor in her spine. My body went cold and I didn't hear a word he said. All I could think about was holding my daughter. Everything after that happened so fast.
The next day we saw a neurosurgeon who confirmed that it was probably a mxyopapillary ependymoma based on the tumor’s location. That night, she had a total brain and spine MRI, which thankfully, confirmed no other tumors. On July 31, 2017, she was scheduled for surgery.  After six hours, we met with the doctor who was able to perform a total resection. He also assured us that these tumors are usually benign and radiation wouldn't be necessary. Two weeks later, the pathology reports came back and showed some mitosis and Ki-67 of 14%. Again, the doctor felt confident that the tumor was gone and suggested just keeping an eye on it.

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