The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
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This issue of The Reading List will be our last of 2025. Tune in next year for some fresh 2026 papers. Happy holidays!
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Department of Biochemistry
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Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against Neisseria gonorrhoeae Gyrase and Topoisomerase IV in Cells and In Vitro. ACS Infectious Diseases.
Alexandria Oviatt*, Jessica Collins, Chelsea Mann, Neil Osheroff*.
School of Medicine Basic Sciences: Osheroff lab provides mechanistic data in successful FDA application for new gonorrhea treatment -
Structural Basis of PPARγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist FX-909. Journal of Medicinal Chemistry.
Zane Laughlin*, Liudmyla Arifova, Paola Munoz-Tello, Xiaoyu Yu, Mithun Nag Karadi Giridhar, Jinhui Dong, Joel Harp, Douglas Kojetin*.
Supported by the Biomolecular NMR Facility.
Center for Structural Biology: Mechanistic insights into FX-909: a next-generation PPARγ inverse agonist -
A Memorial Tribute to Paul Okano (May 1, 1944–October 16, 2025). Chemical Research in Toxicology.
Lawrence Marnett*. -
FET proteins and PARylation-dependent condensates promote replication fork reversal and genome stability (preprint). bioRxiv.
Celeste Giansanti*, Jack Schultz, David Cortez*.
Supported by the Proteomics Core Laboratory. -
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis. Atherosclerosis.
Elizabeth Semler*, Danielle Michell, Philip Kingsley, Marisol Ramirez, Clark Massick, Mark Castleberry, Amanda Doran, John Carr, Lawrence Marnett, Quanhu Sheng, MacRae Linton, Kasey Vickers*.
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Department of Cell and Developmental Biology |
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Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention. American Journal of Human Genetics.
Qing Li*, Qingyuan Song*, Zhishan Chen*, Jie Ping, Wanqing Wen, Chao Li, Xiao-Ou Shu, Qiuyin Cai, Jirong Long, Bhuminder Singh, Ken Lau, Wei Zheng, Zhijun Yin*, Xingyi Guo*.
VUMC News: Large-scale integration of genomics, proteomics and clinical records identifies cancer risk proteins and potential therapeutics. -
The mitotic functions of a fission yeast CK1 enzyme are regulated by Cdk1-dependent and auto-phosphorylation. Journal of Biological Chemistry.
Kazutoshi Akizuki*, Sierra Cullati, Alyssa Johnson, Jun-Song Chen, Alaina Willet, Kathleen Gould*. -
Reprogramming the Course of Precancer with Targeted Therapeutic Intervention: Lessons from Interception in Gastric Preneoplasia. Cancer Prevention Research.
James Goldenring*, Eunyoung Choi. - Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia. Cell Reports.
Vincent Quoc-Huy Trinh*, Katherine Ankenbauer*, Sabrina Torbit, Christopher Taranto, Jiayue Liu, Frank Revetta, Zhengyi Chen, Angela Kruse, Audra Judd, Celina Copeland, Olivia Ben-Levy, Brenda Jarvis, Monica Brown, Jeffrey Spraggins, Ken Lau, Marcus Tan, Kathleen DelGiorno*.
Supported by Creative Data Solutions.
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Department of Molecular Physiology and Biophysics |
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An organ-on-a-chip investigation into dose-dependent, temporal dynamic effects of radiosurgery on the blood–brain barrier and its immunological response. Brain Research.
Adam Yock*, Jacquelyn Brown, John Eley, Cara Lwin, Dandan Liu, John Wikswo. -
Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion. Molecular Metabolism.
Matthew Dickerson*, Prasanna Dadi, Reagan McDevitt, Jordyn Dobson, Soma Behera, Spencer Peachee, Shannon Gibson, Tenzin Wangmo, David Jacobson.
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Department of Pharmacology |
- Intranasal cocaine self-administration in male mice. Nature Communications.
Kirsty Erickson*, Yizhen Quan, Zahra Farahbakhsh, Hannah Branthwaite, Keaton Song, Justin Kim, Janice Lee, Katherine Gibson-Corley, Cody Siciliano*. - Rational design of biased G protein-coupled receptor agonists. Molecular Pharmacology.
Vsevolod Gurevich*. -
Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity. Molecular Psychiatry.
Burak Uzay, Kevin Zhang, Lisa Monteggia, Ege Kavalali.
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Other Vanderbilt basic biomedical research |
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MDR1 promotes CD8 T cell persistence in tumors and protects against cytotoxic chemotherapy (preprint). bioRxiv.
Lincoln Brown*, Megan Erwin, Natalie Favret, Claudia McDavid, Jessica Roetman, Zachary Ewell, Melissa Wolf, Kristen Murray, Jack Smithwick, Marti Goemann, Mary Philip*.
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First or corresponding authors are identified with an *. Only Vanderbilt collaborators are listed except for first authors.
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Papers must be submitted by email by noon on Thursdays to be included in the following week’s newsletter.
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Vanderbilt University School of Medicine Basic Sciences
MRB III U-B1200 465 21st Avenue South
Nashville, TN 37240
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