School of Medicine Basic Sciences departments

Biochemistry

• An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation. FEBS Open Bio.
  Sagar Khavnekar* (Max Planck Institute of Biochemistry), William Wan*.
  
  
• Preserving Full Spectrum Information in Imaging Mass Spectrometry Data Reduction. Bioinformatics.
  Roger Moens* (Delft University of Technology), Jacqueline Van Ardenne, Eric Skaar, Jeffrey Spraggins, Raf Van de Plas*.
  
  Supported by the Mass Spectrometry Research Center.
  
  
• Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification. Cell Reports.
  Lindsey Guerin*, Timothy Scott, Jacqueline Yap, Yilin Yang, Alan Simmons, Ken Lau, Rebecca Ihrie, Emily Hodges*.
  
  
• Mechanistic insight into anaphase bridge signaling to the abscission checkpoint. The EMBO Journal.
  Manika Singh* (University of Copenhagen), Rahul Bhowmick*.

Cell and Developmental Biology

• Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches. Molecular Biology of the Cell.
  Margret Fye*, Pranoy Sangowdar, Anissa Jayathilake, Pi'ilani Regan, Guoqiang Gu, Irina Kaverina*.
  
  
• Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases. Clinical Genetics.
  Diana Brightman* (Cincinnati Children's Hospital Medical Center), Sabine Fuhrmann.
  

Molecular Physiology and Biophysics

• Genetic study of von Willebrand factor antigen levels ≤ 50 IU/dL identifies variants associated with increased risk of VWD and bleeding. Journal of Thrombosis and Haemostasis.
  Rachel Friedman* (The University of Texas Health Science Center at Houston), James Baker, Hung-Hsin Chen, David Samuels, Jennifer Below.

Pharmacology

• Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity. Science.
  Z. Zack Ma*, Natalie Guzikowski, Ji-Woon Kim, Ege Kavalali, Lisa Monteggia*.
  
  
• MeCP2 prevents against sustained ketamine-induced synaptic depression at inhibitory synapses. iScience.
  Michelle Piazza*, Abigael Weit, Ege Kavalali, Jeffrey Neul, Lisa Monteggia*.
  
  
• Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound. ACS Medicinal Chemistry Letters.
  Motoyuki Tanaka* (Ono Pharmaceutical Co.), Elizabeth Childress, Sean Bollinger, Trevor Chopko, Thomas Bridges, Douglas Stafford, Zhonping Huang, Mark Wolf, Darren Engers, Jerod Denton, Craig Lindsley*.
  
  
• Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications. Molecular Nutrition & Food Research.
  María Ángeles Ávila-Gálvez* (Centro de Edafología y Biología Aplicada del Segura–Consejo Superior de Investigaciones Científicas), Claus Schneider.

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