The Reading List is a newsletter from the School of Medicine Basic Sciences in which we amplify biomedical research from our four departments and campus-wide collaborators.
Week of January 13
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| Welcome back to campus! We hope you have a productive and enjoyable spring semester 🌸
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By Basic Sciences department Biochemistry- Bengt I. Samuelsson. National Academy of Sciences website.
Lawrence Marnett*.
- Inositol phosphates dynamically enhance stability, solubility and catalytic activity of mTOR. Journal of Biological Chemistry.
Lucia Rameh*, John York, Raymond Blind*.
- Contributing factors to the oxidation-induced mutational landscape in human cells. Nature Communications.
Cameron Cordero* (University of Vermont), Kavi Mehta*, Tyler Weaver* (University of Kansas Medical Center), David Cortez*.
- Small-Molecule Modulators of Lipid Raft Stability and Protein-Raft Partitioning (preprint). bioRxiv.
Katherine Stefanski*, Hui Huang, Nilabh Saksena, Alexander Fisch, Thomas Hasaka, Joshua Bauer, Charles Sanders*.
Supported by the High-Throughput Screening Facility and the Cell Imaging Shared Resource.
- TOMOMAN: a software package for large-scale cryo-electron tomography data preprocessing, community data sharing and collaborative computing. Journal of Applied Crystallography.
Sagar Khavnekar* (Max Planck Institute of Biochemistry), William Wan*.
Center for Structural Biology: A preprocessing package tailored to individual needs
- Cryo-EM structure of the CBC-ALYREF complex. eLife.
Bradley Clarke*, Alexia Angelos, Menghan Mei, Pate Hill, Yihu Xie, Yi Ren*.
ASBMB Today: New structure gives insight into mRNA export and cancers
- RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data. Journal of Structural Biology.
Minh Tran*, Cristina Martina, Rocco Moretti, Marcus Nagel, Kevin Schey*, Jens Meiler*.
Supported by the Mass Spectrometry Research Center.
Cell and Developmental Biology- Transfer of miR-100 and miR-125b increases 3D growth and invasiveness in recipient cancer cells. Extracellular Vesicles and Circulating Nucleic Acids.
Hannah Nelson*, Shimian Qu, Liyu Huang, Muhammad Shameer, Kevin Corn, Sydney Chapman, Nicole Luthcke, Sara Schuster, Tellie Stamaris, Lauren Turnbull, Lucas Guy, Xiao Liu, Danielle Michell, Elizabeth Semler, Kasey Vickers, Qi Liu, Jeffrey Franklin, Alissa Weaver, Marjan Rafat, Robert Coffey, James Patton*.
- Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer. Developmental Cell.
Daniel Salas-Escabillas* (University of Michigan), Kathleen DelGiorno.
- Prostanoid signaling in retinal cells elicits inflammatory responses relevant to early-stage diabetic retinopathy. Journal of Neuroinflammation.
Amy Stark*, John Penn*.
- Apical clathrin-coated pits control the location, timing, and scale of microvillar growth (preprint). bioRxiv.
Olivia Perkins*, Alexandra Mulligan, Evan Krystofiak, Elkie Peebles, Rekha Nagarajan, Leslie Meenderink, Bryan Millis, Matthew Tyska*.
Supported by the Cell Imaging Shared Resource.
- MCL-1 regulates cellular transitions during oligodendrocyte development (preprint). bioRxiv.
Melanie Gil*, Marina Hanna, Vivian Gama*.
“Our findings highlight how the non-apoptotic function of MCL-1 is essential for the maturation of oligodendrocyte progenitor cells, shedding light on its critical role in oligodendrocyte development,” Melanie Gil.
Supported by the Cell Imaging Shared Resource.
- Epithelial outgrowth through mesenchymal rings drives alveologenesis. JCI Insight.
Nicholas Negretti*, Yeongseo Son, Philip Crooke, Erin Plosa, John Benjamin, Christopher Jetter, Claire Bunn, Nicholas Mignemi, Alice Hackett, Meaghan Ransom, Shriya Garg, David Nichols, Susan Guttentag, Heather Pua, Timothy Blackwell, John Kozub, Anita Mahadevan-Jansen, Evan Krystofiak, Jonathan Kropski, Christopher Wright, Bryan Millis, Jennifer Sucre*.
Molecular Physiology and Biophysics- Modeling Bias Toward Binding Sites in PDB Structural Models (preprint). bioRxiv.
Stephanie Wankowicz*.
- N-lactoyl phenylalanine suppresses appetite and obesity with important implications for aging and age-related diseases. Aging Advances.
Antentor Hinton Jr.*, Kit Neikirk, Han Le, Ashton Oliver, Chanel Harris.
- Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications. Aging Advances.
Antentor Hinton Jr.*, Kit Neikirk, Han Le, Chanel Harris, Ashton Oliver.
- Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways. iScience.
Chunhua Dai*, Yue Zhang*, Yulong Gong, Amber Bradley, Zihan Tang, Katelyn Sellick, Shristi Shrestha, Erick Spears, Brittney Covington, Jade Stanley, Regina Jenkins, Tiffany Richardson, Rebekah Brantley, Katie Coate, Diane Saunders, Jordan Wright, Marcela Brissova, Danielle Dean, Alvin Powers*, Wenbiao Chen*.
Supported by the Cell Imaging Shared Resource.
- Sex- and endurance training-mediated cardiovascular protection through lipids during exercise. Trends in Endocrinology & Metabolism.
Julia An*, Ariel Thorson, David Wasserman, John Stafford, Lin Zhu*.
- Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages. Nature Communications.
Chen Wang* (Penn State University), Havell Markus* (Penn State University), Bingshan Li, Xue Zhong.
- Positive autoregulation of Sox17 is necessary for gallbladder and extrahepatic biliary duct formation. Development.
Linh Trinh*, Ryan Finnel*, Anna Osipovich, Jessica Musselman, Leesa Sampson, Christopher Wright, Mark Magnuson*.
- Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions. Nature Genetics.
Guochong Jia*, Zhishan Chen, Jie Ping, Qiuyin Cai, Ran Tao, Chao Li, Joshua Bauer, Tuya Pal, Sonya Reid, Bingshan Li, Xiao-Ou Shu, Xingyi Guo, Jirong Long, Wei Zheng*.
- Bacteria can anticipate the seasons: Photoperiodism in cyanobacteria. Science.
Maria LuĂsa Jabbur*, Benjamin Bratton, Carl Hirschie Johnson*.
American Society for Microbiology: Bacteria That Change With the Seasons
Pharmacology- Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials. ACS Chemical Neuroscience.
Michael Poslunsey*, Michael Wood, Changho Han, Shaun Stauffer, Joseph Panarese, Bruce Melancon, Julie Engers, Jonathan Dickerson, Weimin Peng, Meredith Noetzel, Hyekyung Cho, Alice Rodriguez, Corey Hopkins, Ryan Morrison, Rachel Crouch, Thomas Bridges, Anna Blobaum, Olivier Boutaud, Scott Daniels, Jerri Rook, Colleen Niswender, Carrie Jones, Jeffrey Conn, Craig Lindsley*.
Basic Sciences: First successful clinical trial of VU319 brings Alzheimer’s treatment one step closer
- Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer's disease. Acta Neuropathologica.
Jared Phillips*, Rebecca Winfree, Mabel Seto, Logan Dumitrescu, Timothy Hohman*.
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi. Chemical Reviews.
Johanna Revol-Cavalier* (Karolinska Institutet), Alan Brash.
- A High-Throughput Immune-Oncology Screen Identifies Immunostimulatory Properties of Cytotoxic Chemotherapy Agents in TNBC. Cancers.
Kennady Bullock*, Thomas Hasaka, Emily Days, Joshua Bauer, Patricia Ward, Ann Richmond*.
Supported by the High-Throughput Screening Facilty.
- Elucidating Sex-Specific Immune Profiles in a Breast Cancer Model. International Journal of Molecular Sciences.
Ebony Hargrove-Wiley*, Wendy Bindeman, Barbara Fingleton*.
- Synaptic Gα12/13 signaling establishes hippocampal PV inhibitory circuits. PNAS.
Krassimira Garbett*, Baris Tosun*, Jaybree Lopez, Cassandra Smith, Kelly Honkanen, Richard Sando*.
Supported by the Cell Imaging Shared Resource.
- Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. ACS Medicinal Chemistry Letters.
Elizabeth Childress*, Rory Capstick, Katherine Crocker, Miranda Ledyard, Aaron Bender, Mallory Maurer, Natasha Billard, Hyekyung Cho, Alice Rodriguez, Colleen Niswender, Weimin Peng, Jerri Rook, Sichen Chang, Anna Blobaum, Olivier Boutaud, Analisa Thompson Gray, Carrie Jones, P. Jeffrey Conn, Andrew Felts, Craig Lindsley*, Kayla Temple*.
- Psychedelics and Entactogens: Call for Papers. ACS Bio & Med Chem Au.
Craig Lindsley*.
- Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection. PLOS Pathogens.
Fan Bu* (University of Minnesota Medical School), Gang Ye* (University of Minnesota Medical School), Kimberly Morsheimer* (Boston University), Benjamin Spiller, Brian Wadzinski.
- A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor (preprint). bioRxiv.
Han Kurt* (Istanbul Medipol University), Chen Zheng, Vsevolod Gurevich.
- Recurrent activity propagates through labile ensembles in macaque dorsolateral prefrontal microcircuits. Current Biology.
Suzanne Nolan*, Patrick Melugin, Kirsty Erickson, Wilson Adams, Zahra Farahbakhsh, Michelle Kwon, Troy Hackett, Christos Constantinidis, Cody Siciliano*.
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Other basic biomedical papers
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First or corresponding authors are identified with a *. Faculty with appointments in Basic Sciences are listed in red. Only Vanderbilt collaborators are listed except for first authors.
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