Forwarded by the Los Angeles County Department of Public Health
| CDPH Health Update:
Increase in Introductions of Clade I Mpox and Increases in Clade II Mpox Within California
June 15, 2026
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The California Department of Public Health (CDPH) issued a health update in response to an increase in travel-related introductions of clade I mpox into California and the U.S. in 2026 and clade II mpox cases have increased in California. Increases in clade I community transmission in Western Europe suggest that additional travel-related clade I mpox cases should be expected in California.
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Clinicians should have a heightened index of suspicion for mpox and particularly for clade I mpox in individuals who report recent international travel or sexual or intimate contact with someone who recently traveled internationally, especially to an area where clade I is circulating.
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Providers and assistants including cleaning staff should wear full PPE (gloves, gown, goggles, and fit tested N-95 respirator).
- Mpox testing should be provided in a timely manner to patients with compatible signs and symptoms, regardless of vaccination status or previous infection.
- Laboratory testing that is positive for orthopoxvirus infection but negative or indeterminate for clade II mpox infection is likely clade I mpox.
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Mpox vaccination with two doses is recommended for individuals who may be at risk for mpox including immune compromised individuals and is expected to protect against both clade I and clade II mpox or any subclades.
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Visit the LAC DPH mpox provider hub for local resources related to vaccination, testing, treatment, and reporting.
Healthcare providers must report all confirmed or suspected clade I mpox immediately by phone (see below). Consultation is also available. Report all mpox or orthopoxvirus infections, hospitalizations, and deaths within 1 working day from identification.
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Los Angeles County DPH Division of HIV and STD Programs:
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- Weekdays 8am–5pm: call 213-368-7441.
- After-hours: call 213-974-1234 and ask for the physician on call.
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Long Beach Health and Human Services:
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- Weekdays 8am-5pm: call 562-570-4302.
- After hours: call 562-500-5537 and ask for the duty officer.
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Pasadena Public Health Department:
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Weekdays 8am-5pm: call 626-744-6089.
- After hours: call 626-744-6043.
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You can also copy and paste this link into your browser https://www.cdph.ca.gov/Programs/OPA/Pages/CAHAN/Increase-in-Introductions-of-Clade-I-Mpox-and-increases-in-Clade-II-Mpox-Within-California.aspx
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To view this and other communications or to sign-up to receive LAHANs, please visit ph.lacounty.gov/lahan.
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